Signaling Networks Controlling Ovarian Cancer Progression and Response to Therapy
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 65
Special Issue Editors
Interests: cell signaling; cancer; metastasis; semaphorin; receptors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With the launch of this Special Issue, we would like to invite contributions illuminating ovarian cancer regulatory mechanisms at all levels. Both research and review articles are welcome.
Ovarian cancer is indeed the leading cause of cancer-related deaths among women in industrialized countries. Compared to other tumor types, our understanding of driver genetic changes and signaling pathways controlling ovarian cancer progression awaits improvement to enable the identification of therapeutic targets. Moreover, the molecular mechanisms controlling responsiveness to chemotherapeutics and innovative therapies remain unclear. It is increasingly recognized that tumors contain heterogenous cancer cell populations, likely reflecting genetic instability, as well as epigenetic adaptation to environmental challenges, including therapy. Notably, in contrast to other cancers, ovarian tumors typically disseminate intraperitoneally, engaging with a peculiar microenvironment across the mesothelial layer. A major hurdle in the study of ovarian cancer is the inadequacy of most models to study genetic instability, stem cell phenotypic plasticity, and intratumor heterogeneity
Prof. Dr. Luca Tamagnone
Dr. Roberta Mastrantonio
Guest Editors
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Keywords
- ovarian cancer
- patient-derived models
- mesothelium
- ascites
- immunotherapy
- chemotherapy
- drug resistance
- metastasis
- peritoneum
- p53
- BRCA
- signaling pathway
- metabolism
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