Improving Enzyme-Based Sensors with Innovative Materials and Techniques
A special issue of Chemosensors (ISSN 2227-9040).
Deadline for manuscript submissions: closed (31 January 2017) | Viewed by 438
Special Issue Editors
Interests: enzyme-based real-time chemical sensors; receptor-based real-time biological sensors; optical sensors; porphyrins and porphyrin-based sensors; nanolayer thin-film sensors; absorbance/fluorescence/evanescent spectroscopy; multiphoton absorbance; photocatalytic degradation of compounds by porphyrins
Interests: protective coatings; distributed sensing; environmental monitoring; self-decontaminating materials, and natural products
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Enzyme-based chemical sensing is the basis for a large and well-established field of research, ranging from commercial products, such as blood glucose monitors, to developments in protein engineering. Advances in materials and techniques offer the potential to extend the applicability of enzyme-based sensing by providing enhancements in enzyme performance or in overall utility. Some examples include improvements in enzyme sensitivity and stability, enhanced control over enzyme orientation, co-localized enzyme and/or cofactor immobilization for cascade processes, and enhanced reporter performance. These types of advances can be driven by the materials used; for example, inorganic nanoparticles, nanowires, and graphene have been shown to improve electron transfer kinetics for redox enzymes in electrochemical sensing schemes; electrospun nanofibers offer high surface area and controlled porosity to enzyme-based sensing approaches. These developments may also be driven by emerging techniques; co-entrapment of enzymes and dye reporters within nanoparticles can provide enhanced detection in lateral flow assays. Overall, the types of innovative materials and techniques currently under development offer the potential to address shortfalls in sensitivity, stability, and selectivity for enzyme-based sensing strategies, making them more suited for use in complex and changing environments. This Special Issue highlights developments providing new or extended capabilities in enzyme-based sensing for environmental and health related applications.
Prof. Dr. H. James Harmon
Dr. Brandy J. Johnson
Guest Editors
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Keywords
- enzyme-based sensing
- enzyme cascade
- immobilization
- orientation
- analysis techniques
- nanomaterials
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