Metabolic Mechanisms of Type 2 Diabetes and Obesity: Challenges and Lessons from Bariatric/Metabolic Surgery
A special issue of Diseases (ISSN 2079-9721).
Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 660
Special Issue Editors
Interests: cardiovascular diseases; diabetes; obesity; atherosclerosis, biomarkers; metabolic syndrome; dyslipidemia; lipid and lipoprotein metabolism; diabetic vascular complications
Special Issues, Collections and Topics in MDPI journals
Interests: diabetes; insulin resistance; vitamin d deficiency; dyslipidemia; metabolic syndrome; congenital hypothyroidism; obesity; diabetes prevention and management; diabetic vascular complications; clinical trials
Special Issue Information
Dear Colleagues,
Severe obesity represents a major risk factor for the development of type 2 diabetes mellitus (T2DM). Most adults with T2DM are overweight or obese, suggesting an important role of increased adiposity as a risk factor for diabetes. Due to a shared common ground between obesity and T2DM, the term of “diabesity” is often used to highlight the causal pathophysiological link between the two phenomena. Numerous clinical trials have advocated bariatric/metabolic surgery over nonsurgical interventions because of markedly superior metabolic outcomes in morbidly overweight and obese patients. Nevertheless, it appears that not all obese patients with T2DM can achieve the most beneficial outcome (e.g., diabetes remission) beyond weight loss and food restriction. Thus, it is highly recommended that patients should be carefully selected based on rigorous preoperative assessment of the risk–benefit ratio prior to surgery. Predictors for diabetes remission following bariatric/metabolic intervention include indices such as preserved pancreatic beta-cell function, shorter duration of diabetes, younger age, higher C-peptide level, potential for an insulin resistance reduction, higher baseline BMI, and visceral fat area. Remarkably, trials have shown a marked variability in outcomes among patients subjected to metabolic surgery, suggesting that other mechanisms may be involved in the development of metabolic deterioration of T2DM in obese patients. At present, the exact metabolic mechanisms in T2DM and obesity are not well defined, and it is not clear yet which metabolic deterioration occurs first, insulin resistance or hyperinsulinemia. Although it has been determined that changes in the gastrointestinal tract, gut microbiome, adipokines levels, and bile acid could be involved in the remission of T2DM, treating T2DM patients by metabolic surgery remains highly controversial in the endocrinology community. More focused research in these areas might be directed to better understand the pathogenesis of obesity and T2DM in order to implement a tailored therapy for patient care and management.
This Special Issue aims to provide an open access platform to publish original research articles dedicated on existing knowledge and challenges in the management of T2DM and obesity. We would also like to invite researchers to submit review articles aimed at providing a comprehensive overview of the recent advances in understanding the molecular basis of T2DM in obesity and its treatment and/or prevention. Researchers from various scientific communities are welcome to present their latest research with a focus on metabolic mechanisms, leading to a better understanding of pathophysiology of T2DM and obesity.
Dr. Ahmed Bakillah
Dr. Ali Al Qarni
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diseases is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Bariatric surgery
- Metabolic surgery
- Type 2 diabetes
- Diabetes mellitus
- Insulin resistance
- Hyperinsulinemia
- Metabolic syndrome
- Obesity
- Diabetes remission
- Weight loss
- Food restriction
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
