Progress in Hematology: Non-malignant, Pre-malignant, and Malignant Disorders, and Genetically Based Therapies
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 15 January 2025 | Viewed by 249
Special Issue Editor
Interests: hematopathology; molecular genetics; anatomic pathology; clinical pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The past two decades have witnessed significant progress in the diagnosis, prognosis, and treatment of many hematologic diseases and in understanding clonal hematopoiesis, including as a potential precursor to hematologic neoplasms. The advances have often been due to an improved understanding of genetics, underlying molecular genetic pathways, and novel genetically or molecularly based therapies. Genetic evaluation, including molecular genetics, cytogenetics, or both, is integral for accurately diagnosing and determining appropriate therapies for many hematologic diseases. Novel genetically based therapies have included curative potential in acquired neoplastic diseases such as chronic myeloid leukemia and inherited non-malignant diseases such as sickle cell anemia. Novel molecular oncologic therapies include genetically targeted therapies in myeloid neoplasms and increasing genetically based applications of measurable residual disease (MRD) detection in hematologic and lymphoid neoplasms. The latter include detecting antigen receptor gene rearrangements following therapy in lymphoid neoplasms such as acute lymphoblastic leukemia, chronic lymphocytic leukemia, and multiple myeloma, BCR::ABL1 in chronic myeloid leukemia, and MRD evaluation in acute myeloid leukemia.
Hematology includes the study of normal and abnormal hematopoiesis and non-malignant and malignant hematologic disorders, which may be inherited or acquired. Non-malignant hematologic disorders include disorders of (1) iron metabolism, (2) hemoglobin synthesis, including sickle cell anemia and thalassemia, (3) red blood cells, (4) platelets, hemostasis, and thrombosis, and (5) paroxysmal nocturnal hemoglobinuria, aplastic anemia, and (6) inherited bone marrow failure, which may progress to a hematologic neoplasm. Malignant hematologic disorders include myeloid, lymphoid, histiocytic, and dendritic cell neoplasms. These include acute and chronic leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, mastocytosis, adult and pediatric lymphomas, multiple myeloma, other plasma cell neoplasms, plasmacytoid dendritic cell neoplasms, Langerhans cell neoplasms, including Langerhans cell histiocytosis, and histiocytic neoplasms, including anaplastic lymphoma kinase (ALK)+ histiocytosis and Rosai-Dorfman disease. Precursor lesions for myeloid neoplasms, including clonal hematopoiesis and clonal cytopenia of undetermined significance, and tumor-like lymphoid lesions with B-cell or T-cell predominance are also recognized by the 5th edition of the World Health Organization diagnostic classification of tumors of hematolymphoid tissues.
The second edition of our special issue in Genes welcomes research and review articles related to progress in hematology in the spectrum described above.
Dr. Rina Kansal
Guest Editor
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Keywords
- hematology
- hemoglobinopathies
- erythrocyte disorders
- platelet disorders
- hemophilia
- paroxysmal nocturnal hemoglobinuria
- aplastic anemia
- inherited bone marrow failure
- clonal hematopoiesis
- hematolymphoid tumors
- leukemias
- lymphomas
- multiple myeloma
- clonality
- minimal/measurable residual disease
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