Cancer Cell Proliferation, Differentiation and Metastasis
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (25 December 2020) | Viewed by 270
Special Issue Editor
Interests: cancer cell; tumor-host interactions; high content screenig
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Traditionally, much of translational cancer research relates to the identification of mutations, amplifications, deletions, differential gene expression or epigenetic silencing of oncogenes and tumour suppressor genes. However, the functional consequences of such altered genes on tumour tissues remain much more poorly understood than the precise details of genetic events. How do activated oncogenes change the phenotypic behaviour of tumour cells in the context of living cancer tissues? What is their impact on dynamic processes such as tumour cell proliferation versus differentiation, invasion, and penetration of lymph and blood vessels? How does the functional lack of tumour suppressor genes alter the interaction of tumour and stromal cells, immune cells, vasculature, and generally, the tumour microenvironment (TME)? How relevant are functional changes in signalling pathways for cell-cell and cell-matrix interactions, the architecture or histology of living cancer tissues, and—most importantly—the response to anticancer chemotherapies and radiation? Finally, what is their impact on tumour dormancy, survival of cancer stem cells, therapy failure, and relapse? In this Special Issue, we primarily encourage articles that link genetic and molecular events with functional insights into complex tumour biology. We specifically invite also contributions that introduce novel in vitro or in vivo model systems and assays to elucidate gene functions, or perform target validation, ideally directed towards the unmet clinical needs of personalized cancer medicine and therapy.
Prof. Matthias Nees
Guest Editor
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Keywords
- oncogenes
- tumour suppressor genes
- cancer gene functions
- target validation
- extracellular matrix
- tumour microenvironment
- angiogenesis
- invasion
- chemotherapy
- acquired resistance
- tumour dormancy
- cancer stem cells
- immuno-oncology
- functional assays
- organotypic models
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