Genetic Disorders in Livestock
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".
Deadline for manuscript submissions: closed (31 October 2018) | Viewed by 644
Special Issue Editors
Interests: genomics; genetics; prediction; animal breeding
Interests: skeletal pathology; vitamin D; fibroblast growth factor 23; genetic diseases; inherited diseases; haemoplasmas; fractures
Special Issue Information
Dear colleagues,
Hundreds of Mendelian inherited disorders in livestock have now been published, where at least one likely causal variant has been identified. Although many of these disorders were well known long before one or more causes were identified, in more recently-discovered disorders a likely causal variant is sometimes uncovered very quickly. This is partly due to off-the-shelf availability of whole genome single nucleotide polymorphism (SNP) panels for most livestock species. Those panels enable immediate proof of parentage to demonstrate familial inheritance, and allow genome-wide association studies to be conducted to localise the regions and therefore genes likely harbouring the causal variant. Additionally, next-generation sequencing technology makes a complete screen of an individual genome both fast and relatively inexpensive. Also, population screening for SNP panel haplotypes that are never or rarely homozygous has proven to be particularly productive in uncovering deleterious mutations. Collectively, these developments have increased the speed and effectiveness of shortlisting candidate causal mutations. Demonstrating causality is much more time-consuming and expensive, but homologous disorders in other species like humans and mice often provide compelling evidence without that final demonstration of causality. The development and application of these and other new technologies means the field of livestock medical genetics is a rapidly developing area. Thus, a collection of articles updating the field is timely. We invite investigators to contribute review articles on strategies for discovery or control of likely causal variants, on their occurrence in particular species or in particular genes, as well as original research articles on any topics related to genetic disorders in livestock.
Prof. Dorian J. Garrick
Prof. Frank Nicholas
Dr. Keren Dittmer
Guest Editors
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Keywords
- Recessive conditions
- Dominant disorders
- Embryonic lethality
- Causal variant
- Genome-wide association studies of likely monogenic disorders
- De novo mutations
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