Interaction between Gut Microbiota and Immune System
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Microbial Genetics and Genomics".
Deadline for manuscript submissions: closed (28 September 2020) | Viewed by 384
Special Issue Editor
Interests: gut microbiota; pathophysiology; functional gastrointestinal disorders; antibiotics; probiotics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gut microbiota account for several bacterial species, protozoa, actinomices, fungi and, more recently, viruses. Their main functions are metabolic, absorptive, and immunomodulatory.
Gut microbiota contribute to the development of the innate immune system starting from the mucosal associated lymphoid tissue (MALT). In fact, microbiota train the system to acquire immunity to the most common bacterial antigens and avoid development of food and non-food associated allergies. Furthermore, gut microbiota has a deep impact on the modulation of intestinal permeability that is the dynamic barrier of our gut to microbial antigens and toxics.
Gut microbiota helps in intestinal sugar fermentation, proteins putrefaction and absorption of fat, and the processing of bile acids. Thus, microbiota are implicated in food malabsorption pathophysiology and related gastrointestinal symptoms development. Small bowel bacterial overgrowth (SIBO) has been associated with irritable bowel syndrome (IBS). In addition, microbiota have an emerging role in celiac disease development and symptoms control through diet modulation.
Gut microbiota and its relative portion of virome are crucial in triggering, maintaining, and modulating the inflammatory cascade typical of inflammatory bowel diseases (IBD).
More recently, a deep knowledge of the microbial genome has made possible fecal microbiota transplantation, available not only for Clostridium difficile associated symptoms and infection, but also for IBD and other functional bowel disorders. However, more evidences are needed to confirm these first very promising evidences.
Prof. Emidio Scarpellini
Guest Editor
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Keywords
- gut microbiota
- gut virome
- intestinal permeability
- malabsorption
- food intolerance
- food allergy
- inflammatory bowel diseases
- celiac disease
- irritable bowel syndrome
- fecal microbiota transplantation
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