Genes and Pathway Regulating Longevity in Model Organisms
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (20 October 2024) | Viewed by 180
Special Issue Editor
Interests: nutrient sensing pathways; nutrition and oncology; metabolic treatment in degenerative diseases; lifestyle and longevity
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Is aging avoidable? Can life be disentangled from aging and aging-related degenerative diseases? Although we so far have no definitive answer to these questions, Comparative Longevity (CL) has revealed significant differences between mammalian species, suggesting that minor genetic differences may be responsible for the notable differences in lifespan often observed. The example of dogs, whose size, life expectancy and susceptibility to disease can vary greatly even between breeds, suggests that few alleles may have a significant effect on longevity and age-related disease. The identification of the genes and mechanisms regulating longevity has utilized simple model organisms. Worms, yeasts, fruit flies and mice have aided in determining the role of Igf1, Tor, Ras and PI3K as major regulators of longevity and genomic instability, epigenetic derangement, the nutrient response pathway, as well as the rate of telomere shortening, which could be associated to accelerated or delayed aging. Owing to their low cost, genetic resources and limited ethical constraints, model systems can play a significant role in identifying substances, alleles, and the molecular mechanisms capable of modulating aging.
Dr. Mario G. Mirisola
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- genes
- longevity
- model organism
- aging
- genetic
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
