Thrombosis and Haemostasis: Clinical Advances
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Vascular Medicine".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 35
Special Issue Editor
2. Northern Clinical Diagnostics and Thrombovascular Research (NECTAR) Centre, Northern Health, Epping, VIC 3076, Australia
3. Department of Medicine (Northern Health), University of Melbourne, Epping, VIC 3076, Australia
4. Australian Centre for Blood Diseases, Monash University, Melbourne, VIC 3004, Australia
5. School of Health and Biomedical Sciences, RMIT—The Royal Melbourne Institute of Technology, Melbourne, VIC 3000, Australia
Interests: venous thrombosis; thrombosis; cardiovascular disease; anticoagulation
Special Issue Information
Dear Colleagues,
In patients with a first episode of unprovoked VTE, the risk of recurrence can be as high as 25% at five years and 36% at 10 years. Although continued anticoagulation reduces the risk of recurrence, it must be carefully weighed against the risk of bleeding, estimated at 1–4% per year. Existing prediction models for predicting first VTE, subsequent recurrence, and bleeding risks have methodological limitations and insufficient predictive accuracy. A personalised risk assessment and tailored anticoagulation management is crucial to prevent recurrence without unnecessarily putting lower-risk patients at increased risk of anticoagulation-related bleeding. Beyond the recommended minimal duration of anticoagulation, there is no universally recommended long-term duration of anticoagulation, as the risk-benefit differs between individuals. The addition of novel biomarkers in combination with clinical risk assessment models may improve the clinician’s ability to predict such risks at an individual level.
While direct oral anticoagulants (DOACs) have revolutionised anticoagulation management in VTE, the use of DOACs, including the duration and optimal dosing in the setting of patients with cardiovascular comorbidities (e.g., stable atherosclerosis disease, renal impairment), is still under debate. Furthermore, there is increasing interest in targeting other upstream coagulation factors, such as the inhibition of factors XI and XII, as alternative anticoagulation agents with potentially lower bleeding risks. Another area of highlight is the treatment approach for intermediate-risk PE, in which our understanding of best practises remains limited. There is emerging evidence demonstrating improved short-term outcomes following endovascular treatments, but there remains a paucity of evidence of the safety and efficacy of these approaches compared to conservative therapies in the short and long term.
In this Special Issue, we welcome authors to submit papers that address the current and future state of the art in the management of venous and arterial thrombosis.
Dr. Hui Yin Lim
Guest Editor
Manuscript Submission Information
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Keywords
- venous thrombosis
- biomarkers
- bleeding
- direct oral anticoagulants
- pulmonary embolism
- factor XI inhibitors
- factor XII inhibitors
- endovascular treatment
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