Precision Medicine in Anesthesia and Pain
A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 117
Special Issue Editor
Interests: anesthesia; pain; chronic pain; neuropathic pain; acute and chronic postsurgical pain
Special Issue Information
Dear Colleagues,
Chronic pain impacts millions globally, leading to a significant decline in quality of life and placing a heavy burden on healthcare systems. Current treatment options often fail to provide sufficient relief without adverse effects, underscoring the critical need for new therapeutic targets.
Neuropeptide Y (NPY), a neurotransmitter with widespread distribution in both the central and peripheral nervous systems, has emerged as a crucial factor in pain modulation, particularly in chronic pain.
This research topic will explore the complex role of NPY in chronic pain conditions by examining its mechanisms of action, the specific receptors it engages (e.g., Y1, Y2, Y5), and its interactions with stress pathways. The topic will investigate how NPY affects pain perception at both the spinal and brain levels, its influence on inflammation, and the potential dysregulation of NPY signaling in chronic pain conditions, such as neuropathic pain, fibromyalgia, arthritis, and many more.
Additionally, the research topic will explore the potential of targeting NPY receptors as a novel therapeutic approach for pain management. By modulating NPY pathways, there is the possibility to develop innovative treatments that offer effective pain relief while reducing the risks of addiction and tolerance often associated with opioids. Preclinical and clinical research will be evaluated to determine the feasibility of NPY-based therapies and to identify potential challenges in transitioning these findings into clinical use.
The ultimate goal of this research topic is to enhance our understanding of Neuropeptide Y's role in chronic pain and contribute to the development of new, more effective pain management strategies.
We call for original research articles and reviews on behavioral pharmacology, calcium imaging (in vitro and in vivo fiber photometry), electrophysiology, chemogenetics, optogenetics, viral tracing, etc.
Dr. Paramita Basu
Guest Editor
Manuscript Submission Information
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Keywords
- Neuropeptide Y
- chronic pain
- NPY receptors
- therapeutics
- anesthesia
- precision medicine
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