Aspergillus Infections in Patients with Cystic Fibrosis
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Medical Microbiology".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 104
Special Issue Editors
Interests: pediatric infectious diseases; fungal infections; cystic fibrosis
Special Issue Information
Dear Colleagues,
Cystic fibrosis (CF) is the most common genetic disease in Caucasians with poor prognosis. CF patients suffer mainly from chronic lung disease and recurrent infections that lead to respiratory failure. Bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa are considered among the predominant pathogens, and their role has been extensively studied. Fungi are increasingly recognized to have a significant role in the progression of lung disease in CF, with Aspergillus spp. as the most common fungus isolated during respiratory sampling. In several CF patients, inhalation of Aspergillus spores can lead to asymptomatic colonization, bronchitis, sensitization, allergic bronchopulmonary aspergillosis (ABPA), and rarely, invasive aspergillosis or aspergilloma.
Meanwhile, the advent of CFTR modulators was a revolution in CF management and has altered the phenotype and the progression of lung disease. Their impact on fungal lung disease and antifungal immunity is thoroughly investigated.
The present Special Issue aims to bring a collection of original research and review articles together to summarize the most recent knowledge of Aspergillus infections in patients with cystic fibrosis.
We look forward to receiving your contributions.
Dr. Maria Noni
Dr. Stavros E. Doudounakis
Guest Editors
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Keywords
- cystic fibrosis
- fungal infections
- CFTR modulators
- respiratory infections
- Aspergillus spp.
- allergic bronchopulmonary aspergillosis
- fungal bronchitis
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