Development of Antimicrobial and Anti-biofilm Agents
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".
Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 461
Special Issue Editors
Interests: antimicrobial peptides; antibiofilm agents; antivirulence agents; antimicrobial nanoparticles; biomedical systems with antimicrobial and antibiofilm properties
Special Issues, Collections and Topics in MDPI journals
Interests: molecular microbiology; antimicrobials; antibiofilm activity; antimicrobial peptides; antivirulence drugs; antibiotic resistance
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Antibiotics represent one of the pillars upon which modern medicine is based. Therefore, the phenomenon of antibiotic resistance (AMR), which limits or cancels the effectiveness of these molecules, is a serious global health problem. Antibiotic resistance may develop at the level of the single bacterial cell (adaptative resistance) or the community level (natural resistance), which involves the switch from a free-living life form (planktonic) to a sessile multistratified community (biofilm). Biofilms consist of a matrix where a multitude of bacterial cells are encased. The biofilm’s matrix limits the penetration of some classes of antibiotics; in addition, the deepest layers of biofilms contain bacterial subpopulations that are endowed with low metabolic activity and growth rate and are therefore intrinsically resistant to conventional antibiotics. Moreover, the biofilm is an ideal ecological niche for the horizontal transfer of antibiotic resistance genes among bacteria. The formation of biofilms is associated with multidrug resistance and complicates the treatment of infections in patients with vascular, valvular and orthopedic prosthesis.
The focus of this Special Issue is on agents (organic molecules, peptides, phages, etc.) which target the molecular determinants of virulence- and biofilm-associated multifactorial resistance. Another very promising field aims at improving the activity of known antibiotics in the development of nano- and microdelivery systems or delivery via functionalized polymers.
Dr. Domenico Schillaci
Dr. Valentina Catania
Guest Editors
Manuscript Submission Information
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Keywords
- antivirulence agents
- antimicrobial peptides
- quorum sensing inhibitors
- phage therapy
- antimicrobial nanoparticles
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