Aptamers: From Structure to Applications
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (31 August 2019) | Viewed by 338
Special Issue Editor
Interests: chemistry; aptamers; thioaptamers; cancer; 3D printing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The pace of RNA and DNA aptamer development continues to increase each year as more scientists become aware of them and we become more proficient in the methods to generate them. While a variety of novel and rapid selection techniques have been developed in recent years, the relationship between the structures and functions of aptamers should be explored in more depth. Structural studies using molecular dynamics (MD), nuclear magnetic resonance (NMR), X-ray crystallography, and ab initio (quantum mechanics) methods can provide useful information regarding the structural and binding effects of atomic substitutions (e.g., boron, sulphur, fluorine, O-methyl), formation of chimeras or particles, incorporation of unnatural or modified DNA bases, or the role of certain structure motifs, such as G-quadruplexes. This Special Issue aims to review the methods and results of past structural studies of aptamers and discuss how structures affect aptamer binding and function, as well as provide new structure–function studies.
Dr. David E. Volk
Guest Editor
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Keywords
- aptamer
- structure
- NMR
- X-ray crystallography
- function
- ab initio
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