Recent Advances in C–H Functionalization
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 31 January 2025 | Viewed by 135
Special Issue Editor
Interests: C–H activation; nucleophilic reactions; green synthesis; radical reactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
C–H functionalization is a powerful and rapidly growing field in organic chemistry that focuses on the direct conversion of carbon–hydrogen (C–H) bonds into new chemical functionalities without the need for pre-functionalized starting materials. Traditionally, organic synthesis involved the use of functional groups as handles for introducing new chemical moieties. However, C–H functionalization offers a more efficient and atom-economical approach by directly activating and manipulating the ubiquitous C–H bonds present in organic molecules.
This field has gained significant attention in recent years due to its potential to streamline synthetic pathways, reduce waste, and improve overall efficiency in chemical synthesis. By selectively functionalizing C–H bonds, chemists can access novel compounds, streamline synthetic routes, and ultimately accelerate the discovery of new drugs, materials, and agrochemicals. Various strategies have been developed for C–H functionalization, including transition metal-catalyzed reactions, radical reactions, photocatalysis, and enzymatic transformations. These methods enable the selective activation of specific C–H bonds based on factors such as steric hindrance, electronic effects, and directing groups, allowing for precise control over the regioselectivity and chemoselectivity of the transformation.
This Special Issue, entitled “Recent Advances in Carbon–Hydrogen Functionalization”, aims to present all aspects of original research, from synthetic methodology to catalysis, and from materials to biologically active compounds. Review articles focused on the most advanced research topics are also welcome to be submitted.
Dr. Longyong Xie
Guest Editor
Manuscript Submission Information
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Keywords
- C–H activation
- radical reaction
- nucleophilic reaction
- cross-coupling reactions
- transition metal catalysis
- photoredox catalysis
- chemoselectivity
- sustainable synthesis
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