Neuropathic Pain Pharmacology: Efforts to Cure A Deranged, Hyper-Sensitive System
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (1 May 2020) | Viewed by 505
Special Issue Editors
Interests: pharmacology; medicinal plants; chronic pain; nervous system pathologies and treatment; glia; cholinergic receptors; opioid receptors
Special Issues, Collections and Topics in MDPI journals
Interests: neuropathic pain; blood–brain barrier; cadmium toxicity; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neuropathic pain is a pathology per se. It originates from a lesion or disease of the somatosensory nervous system that evokes dysfuntional, plastic modifications of tissues leading to pain persistence. The maladaptive response of the complex cell network dedicated to the trasmission and perception of pain dramatically upsets nociception as well as the physiological substrate of classical analgesics. A novel way of thinking is necessary to plan and develop effective pain relievers. New targets in sensitive neurons, the relevance of glial cells, and the pivotal role of the central nervous system have emerged in recent years in neuropathic pain physiopathology shedding light into the darkness. Nevertheless, patients need effective drugs to relieve pain and, even more, drugs able to restore the altered nervous system and stop chronicization. Thus, this Special Issue is intended to collect experimental results about innovative approaches and, of course, molecules able to control pain as monotherapy or as adjuvant to other pain killers.
Dr. Lorenzo Di Cesare Mannelli
Dr. Alessandra Pacini
Guest Editor
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Keywords
- pain
- nociception
- hyperalgesia
- allodynia
- pain relief
- analgesic
- pain killer
- diabetic neuropathy trauma-induced neuropathy
- chemotherapy-induced neuropathy
- post-herpetic neuralgia
- carpal tunnel syndrome
- maladaptive plasticity
- hyperexcitability
- neuron, microglia
- astrocyte
- dorsal root ganglia
- spinal cord
- pain matrix
- synthetic molecules
- antibodies
- microrna therapeutics
- sirna
- natural products
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