Naturally Inspired Molecules as Inhibitors in Drug Discovery, 2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 37
Special Issue Editors
Interests: flavonoids; drug design; hybrid molecules; MDR reversal; neurodegeneration
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; natural products; curcumin; drug design; multitarget drug discovery; bioactive compounds; neurodegeneration; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
We are pleased to announce a call for papers for this Special Issue, entitled “Naturally Inspired Molecules as Inhibitors in Drug Discovery (2nd Edition)”. It follows the previously successful topic, “Naturally Inspired Molecules as Inhibitors in Drug Discovery”, which was closed on 30 September 2024 and included nine published papers.
Natural products (NPs) have long been regarded as precious sources of inspiration for drug design efforts. Their structural diversity and broad range of molecular scaffolds offer favourable ligand–protein binding motifs, thus enabling the modulation of different cellular pathways and interactions with selected targets. Moreover, their “privileged structures” are considered valuable chemical platforms that can be exploited for the design of structurally related analogues, with the aim of performing structure–activity relationship (SAR) studies, understanding the molecular basis of their mechanisms of action, and expanding their biological profile. This Special Issue aims to contribute to novel advancements in the field of synthetic bioactive molecules related to NPs, with a particular focus on compounds acting as inhibitors or modulators of specific enzymes or signalling pathways. Original articles, as well as reviews regarding studies on naturally inspired compounds, are welcome.
Dr. Alessandra Bisi
Dr. Federica Belluti
Guest Editors
Manuscript Submission Information
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Keywords
- natural products
- drug design
- privileged structures
- enzyme inhibition
- bioactive compounds
- bioinspired compounds
- structure–activity relationship (SAR)
- biological activity
- organic synthesis
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