Catalysis in Protein Crystals
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 562
Special Issue Editors
Interests: crystallography; structural biology; Vitamin B12 proteins; redox-proteins; drug delivery; diagnostics; metals in medicine; bioinorganic chemistry; supramolecular chemistry; nanostructures
Special Issues, Collections and Topics in MDPI journals
Interests: structural biology; crystallography; biocuration; databases; metallo enzymes; miniaturized proteins; citation networks; outreach
Special Issue Information
Dear Colleagues,
Following the first three-dimensional structure determination of hen egg-white lysozyme in 1965 nearly two-third of ~190,000 crystal structures currently housed in the Protein Data Bank are represented by enzymes often complexed with their substrates. Fine-tuned dynamic motions regulate the enzymatic catalysis towards specific substrate molecules. Macromolecular crystallography (MX) offers highly informative snapshots of the enzyme in action although it is not an easy task to trap substrates, reaction intermediates, or products in active conformation. These snapshots are challenged by technical aspects because single pictures of the enzyme are an average of the irradiated crystal volume and time of data collection. State-of-the-art of structural biology offers a combination of macromolecular crystallography (MX), Laue diffraction, and emerging technique of Mix-and-Inject Serial Crystallography (MISC) at X-ray free-electron laser (XFEL) sources for real-time enzyme catalysis in protein crystals. Catalysis in protein crystals represents a major research trend in structural biology and the present Special Issue aims to cover its frontier technologies and methodologies, as well as novel mechanisms and applications.
Prof. Dr. Silvano Geremia
Prof. Dr. Luigi F. Di Costanzo
Guest Editors
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Keywords
- enzymatic catalysis
- enzyme mechanisms
- intermediate of reaction
- Laue diffraction
- X-ray free electron laser (XFEL)
- Mix-and-Inject Serial Crystallography (MISC)
- Serial femtosecond crystallography (SFX)
- multiple serial structures from one crystal (MSOX)
- single crystal UV/vis and fluorescence spectroscopy
- protein metal-organic framework
- diffusion process in crystal
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