New Drugs Acting on Ubiquitin-Proteasome System
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 386
Special Issue Editor
Interests: semisynthetic steroids; diterpenoid and triterpenoid derivatives with improved antitumor activity and investigation of their mechanisms of anticancer action; cancer research; novel PARP-1 inhibitors; enzyme inhibitors able to tackle hormone-dependent cancers, such as 5alpha-reductase and CYP17 inhibitors; new drugs acting on the ubiquitin–proteasome system (UPS); inhibitors of BACE1 and glutaminyl cyclase for Alzheimer’s disease treatment; green pharmaceutical processes
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Special Issue Information
Dear Colleagues,
The controlled regulation of protein turnover is fundamental for the maintenance of cellular homeostasis and viability. The ubiquitin–proteasome system (UPS) is a crucial regulator for the targeted degradation of proteins in eukaryotic cells in diverse cellular processes, such as apoptosis induction, cell cycle control, transcriptional activation, DNA repair, etc. Considering its involvement in a broad spectrum of biological functions, it is not surprising that deregulation of the UPS leads to several different disease states, including various cancers as well as neurodegenerative disorders. UPS comprises a group of enzymes such as E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin–protein ligases) that tag proteins with the small-molecule ubiquitin (Ub), and the multi-subunit proteolytic complex, the 26S proteasome, a highly specific molecular device that degrades Ub-tagged substrate proteins into small molecular peptides involved in other biological functions. Deubiquitinases (DUBs) regulate biological processes associated with cell proliferation and apoptosis and are components of the UPS that catalyze the removal of ubiquitin moieties from target proteins or polyubiquitin chains, resulting in altered signaling or changes in protein stability. Ubiquitin-specific proteases (USPs) are the largest subfamily of DUBs. This Special Issue aims to provide an opportunity to share new findings and recent advances in UPS-targeted small molecules toward the development of new anticancer drugs.
Prof. Dr. Jorge A. R. Salvador
Guest Editor
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Keywords
- Proteasome inhibitors
- Ubiquitin-activating enzymes inhibitors
- Ubiquitin-conjugating enzymes inhibitors
- Ubiquitin–protein ligases inhibitors
- Ubiquitin-specific proteases (USPs) inhibitors
- Other deubiquitinases inhibitors
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