The Relationship between Oxidative Damage and Tissue Remodelling/Aberrant Repair during Chronic Inflammation

Dear Colleagues,

Oxidative stress as a concept was formulated in 1985, and to date, approximately over 237,000 entries appear in Pubmed for this term. Under normal physiological conditions, reactive oxygen species—a byproduct of aerobic metabolism—induces oxidative stress which is critically important for the activation of redox switches essential for normal cellular and tissue homeostasis. Reactive oxygen species are also generated via NADPH and lipoxygenase systems from innate immune cells and have an important microbicide function. However, sustained oxidative stress coupled with an exhausted antioxidant system can lead to irreparable damage to vital host cellular proteins, lipids, and DNA components—a phenomenon coined “oxidative damage”, whereby the accumulative oxidized products alter cell function and can result in cell death. 

Oxidative damage is linked to almost every disease and in particular chronic inflammatory conditions, where damage of tissue proteins and lipids impacts on the “organisation and repair” phase of inflammation, impairing tissue repair and resulting in pathophysiological ECM remodelling.

This Special Issue aims to highlight the role of oxidative stress/damage in modulating the ECM and tissue repair in chronic inflammatory diseases. We welcome systemic reviews and primary research articles that highlight the role of redox systems in tissue repair.

Potential topics include but are not limited to:

• Oxidative stress/damage and wound healing;
• Pharmacological interventions directly/indirectly affecting redox systems and subsequent disease outcomes;
• Methods and approaches to detecting oxidative stress/damage biomarkers in chronic inflammatory conditions;
• Oxidative stress/damage, matrix metalloproteinase activity, and fibrosis during acute and chronic inflammation;
• Oxidative stress biomarkers in chronic inflammatory conditions and impaired tissue repair;
• Endogenous antioxidant systems and modulation of ECM remodelling.

Dr. Belal Chami
Guest Editor

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• oxidative stress
• inflammation
• tissue repair
• ECM remodelling
• wound healing