Targeting the Lungs: The Potential of Aerosolized Medications in Gene Therapy
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 28 February 2025 | Viewed by 117
Special Issue Editors
2. CHRU de Brest, Service de Génétique Médicale et Biologie de la Reproduction, Centre de Référence des Maladies Rares “Maladies Neuromusculaires”, F-29200 Brest, France
Interests: gene transfer; human genomics; cystic fibrosis; nanoparticles; recombinant virus; lung delivery; aerosol; in vivo applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Aerosol delivery is particularly effective for treating pulmonary diseases, such as COPD, asthma, cystic fibrosis, lung cancers, and pulmonary infections. Additionally, this method is well suited for delivering innovative treatments to the lungs, such as gene therapy. The use of various nucleic acid constructs is continually increasing, with applications now extending to both hereditary and acquired diseases for curative or preventive purposes, such as vaccination. Given the critical role of respiratory function in human physiology, the lungs and the diverse pathologies that can affect them are receiving significant attention in the development of new therapeutic approaches. Pulmonary delivery represents an attractive option for drug administration as it is both localized and non-invasive and provides a direct route to the general circulation, bypassing the liver’s first-pass effect and enhancing bioavailability.
This Special Issue aims to gather original articles and reviews on aerosol delivery for gene therapy, encompassing advanced drug delivery approaches and systems such as drug formulations, nanoparticle-based methods, viral vectors, drug delivery devices, and related innovations. Studies involving all types of nucleic acid strategies, including CRISPR-Cas9, siRNA, pDNA, and nucleic acid-based vaccines, are welcome.
Prof. Dr. Tristan Montier
Dr. Rosy Ghanem
Guest Editors
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Keywords
- aerosol delivery
- gene therapy
- lipid-based gene delivery
- viral vectors
- pulmonary disease
- nucleic acid-based vaccines
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