Extracellular Matrix and Vesicles as Immunomodulatory Therapeutics

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 87

Special Issue Editors


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Guest Editor
Department of Pulmonary Medicine, University Hospital Bern, 3010 Bern, Switzerland
Interests: stem cells; secretome; extracellular vesicles; targeted drug delivery; gene and cell therapy; lung repair and regeneration

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Guest Editor
1. McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15219, USA
2. Viscus Biologics LLC., 2603 Miles Road, Cleveland, OH 44128, USA
Interests: medical devices; clinical translation; extracellular matrix; extracellular vesicles
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Guest Editor
School of Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
Interests: stem cells; tissue engineering; extracellular vesicles; biomaterials; immunology; ageing; extracellular matrix
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Guest Editor
Instituto de Investigación Hospital 12 de Octubre i+12, Madrid, Spain
Interests: regenerative medicine; nanomedicine; mesenchymal stromal cells; targeted cell therapy; regeneration; cancer therapy
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Special Issue Information

Dear Colleagues,

In this Special Issue of Pharmaceutics, titled “Extracellular Matrix and Vesicles as Immunomodulatory Therapeutics”, we delve into the implications of utilizing extracellular matrix (ECM)-based biomaterials and extracellular vesicles (EVs) as immune response-modulating agents. ECM and EVs play essential roles in the response and coordination of the immune system in health and disease, which qualifies them as powerful tools (both on their own or combined) for immunomodulatory agents. The importance of this field is further underscored by their potential to develop targeted immunotherapies and chronic inflammation treatments with enhanced efficacy and reduced side effects. Hence, the purpose of this Special Issue is to showcase the latest research on the pharmaceutical applications of ECM and extracellular vesicle-based therapeutics alone or combined, including their design, optimization, and therapeutic immunomodulatory efficacy. This collection aims to provide a comprehensive overview of how these innovative approaches can be harnessed to advance drug delivery and immunomodulation to clinical translation.

Dr. Amiq Gazdhar 
Dr. Héctor Capella-Monsonís
Dr. William D’Angelo
Dr. Ana Isabel Flores
Guest Editors

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Keywords

  • extracellular matrix
  • extracellular vesicles
  • inflammation
  • immunomodulation
  • regenerative medicine
  • drug delivery
  • clinical translation

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