Advances in Difficult Protein–Protein Interaction Determination
A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Life Sciences".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 888
Special Issue Editors
Interests: structural bioinformatics; bioinformatics; next-generation sequence; drug design; deep learning
Special Issues, Collections and Topics in MDPI journals
Interests: biochemistry and molecular modelling
Special Issue Information
Dear Colleagues,
The field of structural biology has recently seen tremendous advances in the identification and characterization of macromolecules, with breakthroughs in cryo-microscopy at the angstrom level and the high-fidelity, large-scale prediction of protein structures using deep-learning approaches, as demonstrated by AlphaFold2. With the COVID-19 pandemic outbreak, it became very obvious that for some proteins, even if it was possible to routinely detect and express them, it is still very challenging to resolve their atomic arrangement. Many proteins are membranous and require dimerization or even a higher order of organization. Although difficult to resolve experimentally, these proteins are essential to cell function, for mediating transient protein–protein interactions, triggering cell activation after cytokine stimulation, or determining cell fate via apoptosis activation. Many membrane proteins are also key targets for pharmaceutical purposes; for instance, half of the drugs approved by the FDA target a GPCR member. Although important scientific breakthroughs have recently been made, there is still a fundamental need for adding knowledge in protein interactions in membranous or cytosolic compartments. This Issue aims to present advances in protein–protein interactions where symmetry is important for structure and/or function. Authors submitting manuscripts for this Special Issue should cover one or more of the following topics: membrane protein, intrinsically disordered proteins/segments, pore formation, macromolecular assembly, protein–DNA interactions.
Dr. Alexandre G. De Brevern
Dr. Stéphane Téletchéa
Dr. Jérémy Esque
Guest Editors
Manuscript Submission Information
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Keywords
- protein–protein interactions
- membrane proteins
- intrinsically disordered proteins
- macromolecular assembly
- protein–DNA complex
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