Challenging Aspects of Botulinum Toxin Therapy
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (19 October 2021) | Viewed by 555
Special Issue Editors
Interests: botulinum toxin therapy; pathogenesis of sensorimotor integration disorders; heavy metal intoxication
Special Issues, Collections and Topics in MDPI journals
Interests: multiple sclerosis; neuromyelitis spectrum disorders; optical coherence tomography; visual evoked potentials; botulinum neurotoxin therapy; general neurology
2. Experimental and Clinical Research Center, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
3. Department of Regional Health Research and Molecular Medicine, University of Southern Denmark, Odense, Denmark
4. Department of Neurology, Slagelse Hospital, Slagelse, Denmark
Interests: multiple sclerosis; clinical neurology; movement disorders; demyelinating diseases; neuroimmunology; neuro-ophthalmology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This issue is aimed at describing the history of botulinum neurotoxin (BoNT) therapy and the development of the broad spectrum of neurological and non-neurological indications. It also deals with the continuous purification attempts to improve biological function and to reduce immunoresistance. It emphasizes that BoNT-therapy is highly effective, but is not a causal therapy. For a good outcome tissue, muscle and dose selection have to be optimized and different guidance techniques should be used. Knowledge of the course of disease before and after BoNT-therapy is important. This underlines the relevance of documentation of injection sites, dose per site and the use of clinical scores for carefully monitoring BoNT-therapy carefully and the assessment of patients´ experience of improvement of quality of life. The side effects of BoNT-therapy are mild and sometimes overestimated. Development of an immunoresistance can be a limiting factor of BoNT-therapy. Different clinical and laboratory tests have been developed for the early detection of a partial secondary treatment failure. Possible strategies how to proceed when a secondary treatment failure has become clinically manifest should also be included into this issue.
This issue would cover the mentioned above aspects in general with focus on following points:
- Botulinum neurotoxin (BoNT) therapy in clinical neurology
- Gathering real world evidence for neurological BoNT therapy
- Established and emerging indications
- Personal experience with tips and tricks in neurological BoNT therapy
- Issues related to BoNT/A therapy and neutralizing antibodies
- Laboratory and clinical tests for detecting antibody formation
- Special cases in Botulinum Toxin Therapy (case reports and literature reviews) (cases without BoNT indication approval – therapy resistant cases – unusual cases -…)
- BoNT therapy challenges in the time of Covid-19 pandemic and lockdown
Prof. Dr. Harald Hefter
Prof. Dr. Philipp Albrecht
Dr. Sara Samadzadeh
Dr. John-Ih Lee
Guest Editors
Manuscript Submission Information
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Keywords
- botulinum neurotoxin (BoNT)
- botulinum neurotoxin type A(BoNT/A)
- neutralizing antibodies
- immunoresistance
- primary and secondary treatment failure
- antigenicity
- complex protein-free BoNT/A
- complex protein containing BoNT/A
- therapy switching
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