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Molecules
Volume 27
Issue 23
10.3390/molecules27238379
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Peer-Review Record

Tellurium-Modified Nucleosides, Nucleotides, and Nucleic Acids with Potential Applications

Molecules 2022, 27(23), 8379; https://doi.org/10.3390/molecules27238379
by Cen Chen 1,2 and Zhen Huang 1,3,*
Reviewer 1:
Zhenjun Yang
Molecules 2022, 27(23), 8379; https://doi.org/10.3390/molecules27238379
Submission received: 20 October 2022 / Revised: 22 November 2022 / Accepted: 23 November 2022 / Published: 1 December 2022
(This article belongs to the Special Issue Nucleic Acid Chemical Biology: An Honorary Issue for Professor Li-He Zhang on the Occasion of His 85th Birthday)

Round 1

Reviewer 1 Report

The review paper “Tellurium-Modified Nucleosides, Nucleotides and Nucleic Acids with Potential Applications” is significant for readers. It's suggested this paper to be published in Molecules after minor revision as labelled in the attached PDF file.

Comments for author File: Comments.pdf

Author Response

Dear reviewer,

We appreciate you taking the time to review our paper. All changes were made according to the marks in the draft. The revised manuscript was attached.

Best,

Cen

Author Response File: Author Response.docx

Reviewer 2 Report

The heavy element Tellurium has been incorporated into proteins and used to determine the structure of proteins using X-ray crystallography. The review highlights the development of Te-modified nucleosides, nucleotides, and nucleic acids. A tellurium-modified 2' and 5-position nucleoside has been successfully synthesized and both are compatible with solid phase synthesis, deprotection and purification. Tellurium's ideal electronic and atomic properties for generating clear isomorphic signals give Te-modified DNA and RNA great potential for determining three-dimensional crystal structure using X-ray diffraction. The STM study also shows that Te-modified DNA has strong topographic and current peaks, immediately suggesting potential applications in direct nucleic acid imaging, nanomaterials, molecular electronics, and diagnostics. The special redox properties and selective removal of the modified 2'-Te DNA oligonucleotide can be useful in the study of DNA fragmentation and damage to nitrogenous bases. In addition, due to the metallic properties of the tellurium atom, the Te-modified DNA duplex becomes visible on STM, suggesting a promising strategy for direct DNA imaging without structural disruption. Theoretical studies point to the potential use of Te-modified nucleosides in cancer therapy.

The article is undoubtedly interesting and can be published after “minor revision

Comments for author File: Comments.pdf

Author Response

Dear reviewer,

We appreciate you taking the time to review our paper. Minor changes about spelling and style were made. The revised manuscript was attached.

Best,

Cen

Author Response File: Author Response.docx

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