The Purinergic Landscape of Type 2 Diabetes Mellitus
, Leticia Scussel Bergamin 1, Valentina Vultaggio-Poma 1, Maria Luiza Thorstenberg 1, Mario Tarantini 1, Mariana Haydee GarcÃa-Hernández 2 and Francesco Di Virgilio 1,*Round 1
Reviewer 1 Report
The review is perfectly written. I suggest to accept the article in its current form.
Authors are focused on dysregulated eATP homeostasis is a pathogenic factor in several chronic inflammatory diseases, including type 2 diabetes mellitus (T2DM), that has some inflammatory related aspects in its pathophysiology. Most important that inflammation negatively affectes the insulin production from pancreatic β-cells. It is known that eATP increased levels in T2DM is one of the factors for bwta cells damage via activation of P2X7 receptor that leading to massive release of inflammatory cytokines. Furthermore, P2X7R inhibition might be used for the blocking of apoptosis of pancreatic β-cells, thus further aggravating hyperglycemia. Such new drugs/therapeutics might be used for the development of novel antidiabetic and beta-cells protective drugs. A lot of data was generated already regarding that link between inflammation, beta cells apoptosis and activation of P2X7 receptor and the authors are making nice summary regarding the subject.Author Response
The review is perfectly written. I suggest to accept the article in its current form.
Authors are focused on dysregulated eATP homeostasis is a pathogenic factor in several chronic inflammatory diseases, including type 2 diabetes mellitus (T2DM), that has some inflammatory related aspects in its pathophysiology. Most important that inflammation negatively affectes the insulin production from pancreatic β-cells. It is known that eATP increased levels in T2DM is one of the factors for bwta cells damage via activation of P2X7 receptor that leading to massive release of inflammatory cytokines. Furthermore, P2X7R inhibition might be used for the blocking of apoptosis of pancreatic β-cells, thus further aggravating hyperglycemia. Such new drugs/therapeutics might be used for the development of novel antidiabetic and beta-cells protective drugs. A lot of data was generated already regarding that link between inflammation, beta cells apoptosis and activation of P2X7 receptor and the authors are making nice summary regarding the subject.
We thank the Reviewer for his/her very positive report.
Reviewer 2 Report
This Review is devoted to the important topic, well illustrated, may be recommended for publication. Small recommendation - to show more results
on fat tissue in Type 2 Diabetes and Type 1 Diabetes;
what models can be used for study of T2D and T1D?
Author Response
This Review is devoted to the important topic, well illustrated, may be recommended for publication. Small recommendation - to show more results on fat tissue in Type 2 Diabetes and Type 1 Diabetes. What kind of models can be used for the study of T1DM and T2DM?
We thanks the Reviewer for his/her very positive report. Despite this review is mainly focused on T2DM, we have now added a short comment on adipose tissue, T1DN and, more importantly, on animal models for the study of diabetes mellitus (lines 38-56 and lines 167-171). We hope that the Reviewer will find this addition of his/her satisfaction.
