Leaky Gut and the Ingredients That Help Treat It: A Review
Magdalena Lis
Round 1
Reviewer 1 Report
To authors,
In the manuscript, the authors summarized the role of ingredients on leaky gut condition. The contents are well-written. However, there are several concerns that should be improved.
1) In Fig.3, the authors used words "Chemical barrier". What one do the "Chemical barrier" refer to in the Figure3? Is the words "Chemical barrier" really adequate? The description is confusing, therefore I recommend the authors to improve it.
2) It is very difficult to see the difference between upper and lower parts in Figure5. Especially, "X" on the arrows in upper part. In addition, it is very confusing about the orange and blue arrows, and descriptions in right part. Figure 5 should be improved to make it easier to understand by readers.
3) It is very hard to see or to understand the contents in all of tables! It should be improved to make it easier to catch the contents at a glance!
Author Response
COMMENT: “In Fig.3, the authors used words "Chemical barrier". What one do the "Chemical barrier" refer to in the Figure3? Is the words "Chemical barrier" really adequate? The description is confusing, therefore I recommend the authors to improve it”.
RESPONSE: Chemical barrier tries to conjugate (put together) where most digestive acid (secreted by gastrointestinal tract), digestive enzymes, lysozyme, mucopolysaccharides, glycoproteins, and glycolipids are located in the intestinal barrier system. The image was in improved a suggested.
COMMENT: It is very difficult to see the difference between upper and lower parts in Figure5. Especially, "X" on the arrows in upper part. In addition, it is very confusing about the orange and blue arrows, and descriptions in right part. Figure 5 should be improved to make it easier to understand by readers.
RESPONSE: Fig 5 is now improved.
COMMENT: It is very hard to see or to understand the contents in all of tables! It should be improved to make it easier to catch the contents at a glance!
RESPONSE: The tables now improved. In Table titles the word “homeostasis” now changed to regulation in the title, and significance / importance of each table title aspect is now included in the text.
Reviewer 2 Report
Overall, a well-written review article that suggested the role of functional ingredients as mediators of leaky gut disorders. The authors describe that under normal circumstances, a healthy intestinal barrier prevents toxic elements from entering the bloodstream. Various factors, on the other hand, may disturb the composition of the intestinal microflora and the homeostasis of the intestinal barrier function, leading to increased intestinal permeability. Excessive permeability of the intestines can therefore allow the entry of harmful agents that enter the bloodstream and affect various organs and systems. Thus, leaky gut syndrome and intestinal barrier dysfunction are associated with intestinal diseases such as inflammatory bowel disease and irritable bowel syndrome as well as extra-intestinal diseases including heart disease, obesity, type 1 diabetes and celiac disease. Given the relationship between intestinal permeability and numerous conditions, it is convenient to look for an excellent strategy to avoid or limit the increase in intestinal permeability. The influence of dietary nutrients on barrier function may be crucial for the design of new strategies for patients with the pathogenesis of leaky gut diseases related to epithelial barrier dysfunctions. The article is written clearly and interestingly. A large number of literature items shows that the authors have thoroughly analyzed the topic under study.
Comments for author File: 
Comments.docx
Author Response
COMMENT: “Overall, a well-written review article that suggested the role of functional ingredients as mediators of leaky gut disorders. The authors describe that under normal circumstances, a healthy intestinal barrier prevents toxic elements from entering the bloodstream. Various factors, on the other hand, may disturb the composition of the intestinal microflora and the homeostasis of the intestinal barrier function, leading to increased intestinal permeability. Excessive permeability of the intestines can therefore allow the entry of harmful agents that enter the bloodstream and affect various organs and systems. Thus, leaky gut syndrome and intestinal barrier dysfunction are associated with intestinal diseases such as inflammatory bowel disease and irritable bowel syndrome as well as extra-intestinal diseases including heart disease, obesity, type 1 diabetes and celiac disease. Given the relationship between intestinal permeability and numerous conditions, it is convenient to look for an excellent strategy to avoid or limit the increase in intestinal permeability. The influence of dietary nutrients on barrier function may be crucial for the design of new strategies for patients with the pathogenesis of leaky gut diseases related to epithelial barrier dysfunctions. The article is written clearly and interestingly. A large number of literature items shows that the authors have thoroughly analyzed the topic under study”.
RESPONSE: Thank you.
