Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases
Round 1
Reviewer 1 Report
In this review article, the author summarized the results of sphingolipidomics in biofluids of patients with neurodegenerative diseases, and reported that a common finding in several studies was an increase in ceramide d18:1/16:0, the implication of which was discussed in detail. I think that the manuscript is well organized and very informative, and should be worth publishing in “International Journal of Molecular Sciences” with minor modifications.
[Specific comments]
#1. (page 2, line 50; page 13, line 342; page 14, line 413) to a lesser “extend” should be “extent”.
#2. (page 6, line 138) clarified “throught out” the review should be “throughout”.
#3. (page 6, line 150) two “mayor” classes of SL should be “major”.
Author Response
Thank you very much for reading the review article. I appreciate your comments about the manuscript being well organized and informative.
Thank you for the English corrections, I made the appropriate changes.
Reviewer 2 Report
The submitted manuscript is a comprehensive review on role of sphingolipids in neurodegenration and author has provided adequate references to previous literature. The manuscript appears acceptable in current format.
Author Response
Thank you very much for your comments about the manuscript.
