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Volume 20
Issue 8
10.3390/ijms20082009
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Review
Peer-Review Record

The Role of the Immune System in Cutaneous Squamous Cell Carcinoma

Int. J. Mol. Sci. 2019, 20(8), 2009; https://doi.org/10.3390/ijms20082009
by Matthew J. Bottomley 1,*,†, Jason Thomson 2,†, Catherine Harwood 2 and Irene Leigh 2
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2019, 20(8), 2009; https://doi.org/10.3390/ijms20082009
Submission received: 31 March 2019 / Revised: 16 April 2019 / Accepted: 19 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Molecular Aspects of Cutaneous Squamous Cell Carcinoma)

Round  1

Reviewer 1 Report

This is an interesting review about immune regulation in cutaneous squamous cell carcinoma. The description in which intensive study of the TME across cancer s including the cSCC has begun uncoupling the complex, dynamic interaction between tumors and the multitude of host innate and adaptive immune cells may be revised to include the discussion how TME regulates the interactions between tumor and immune cells.  

Author Response

Reviewer comment 1: This is an interesting review about immune regulation in cutaneous squamous cell carcinoma. The description in which intensive study of the TME across cancer s including the cSCC has begun uncoupling the complex, dynamic interaction between tumors and the multitude of host innate and adaptive immune cells may be revised to include the discussion how TME regulates the interactions between tumor and immune cells.

Response 1: We thank Reviewer 1 for their comments on our review. We have expanded our discussion on how the TME regulates tumour cell -immune cell interactions in the section: "4.3 The Effects of Immunosuppression on The Tumour Microenvironment" and have included references to a few papers that have reviewed this area.

Reviewer 2 Report

Thomson et al. wrote a comprehensive review about the role of the immune system in cutaneous squamous cell carcinoma (SCC). They clearly describe the function of different immune cell populations during SCC development and progression and intensively discuss the role of immunosuppression on SCC development. The manuscript is very clearly written. I have only minor comments.

page 2 lane 45: besides LC, up to 4 dermal DC populations can be identified, which originate from DC-restricted progenitors; in addition monocyte-derived DC an macrophages

page 4 lane 9 and 10: maybe switch IL-22 and iL-33 since ILC2 produce IL-33 and ILC3 produce IL-22

page 4 lane 26 DETC are only found in mice, but there are sparce ggdT cells in human epidermis as well

page 5 lane 13. Explain the abbreviation OTR

Author Response

Point 1: page 2 lane 45: besides LC, up to 4 dermal DC populations can be identified, which originate from DC-restricted progenitors; in addition monocyte-derived DC an macrophages

Response 1: we have clarified that up to 4 dermal DC populations have been identified and added an additional reference.

Point 2: page 4 lane 9 and 10: maybe switch IL-22 and iL-33 since ILC2 produce IL-33 and ILC3 produce IL-22

Response 2: we have amended as suggested by the reviewer.

Point 3: page 4 lane 26 DETC are only found in mice, but there are sparce ggdT cells in human epidermis as well

Response 3: we have amended this section and made a clear distinction between murine and human gamma-delta T cell populations.

Point 4: page 5 lane 13. Explain the abbreviation OTR

Response 4:  amended as per reviewer suggestion, thank you. 

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