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Volume 22
Issue 5
10.3390/ijms22052550
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Review
Peer-Review Record

How Cells Communicate with Each Other in the Tumor Microenvironment: Suggestions to Design Novel Therapeutic Strategies in Cancer Disease

Int. J. Mol. Sci. 2021, 22(5), 2550; https://doi.org/10.3390/ijms22052550
by Roberto Zefferino 1,*, Claudia Piccoli 2, Sante Di Gioia 1, Nazzareno Capitanio 2,† and Massimo Conese 1,†
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2021, 22(5), 2550; https://doi.org/10.3390/ijms22052550
Submission received: 31 January 2021 / Revised: 25 February 2021 / Accepted: 26 February 2021 / Published: 4 March 2021
(This article belongs to the Special Issue Connexin and Pannexin Signaling in Health and Disease)

Round 1

Reviewer 1 Report

The manuscript by Zefferino et al. is focused on the interplay among GJIC, Panx-HCs, and the purinergic system in the TME. The manuscript is timely, well designed with proper references.  However few comments are needed to addressed before it's possible acceptance in this esteemed journal. 

  1. Authors have shown an intrinsic association of DAMP's with TME elements. However, the mitoDAMP's information is missing. Kindly highlight in this context.
  2. Grammatical errors are needed to be rectified throughout the manuscript.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Reviewer 2 Report

This manuscript is a review of interaction with GJIC, Panx-HCs, and the tumor microenvironment for cancer progression, invasion, and metastatization. 
Currently, it is very important to study the microenvironment or tumor immune in cancer treatment.This manuscript is very interesting because This manuscript describes in great detail the role or GJIC and Panx-HCs in tumor microenvironment or immune destruction. I think this manuscript can be published for IJMS.

Author Response

Thanks

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