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Article
Peer-Review Record

Nimodipine Treatment Protects Auditory Hair Cells from Cisplatin-Induced Cell Death Accompanied by Upregulation of LMO4

Int. J. Mol. Sci. 2022, 23(10), 5780; https://doi.org/10.3390/ijms23105780
by Saskia Fritzsche, Christian Strauss, Christian Scheller † and Sandra Leisz *,†
Reviewer 1: Anonymous
Reviewer 2:
Int. J. Mol. Sci. 2022, 23(10), 5780; https://doi.org/10.3390/ijms23105780
Submission received: 12 April 2022 / Revised: 17 May 2022 / Accepted: 19 May 2022 / Published: 21 May 2022
(This article belongs to the Special Issue The Discovery and Development of Cisplatin)

Round 1

Reviewer 1 Report

Dear authors,
the manuscript you submitted is of interest for the use of cisplatin in chemotherapy therapy. Side effects such as ototoxicity appear to be reduced with the combination of nimodipine with cisplatin. This would increase the patient's well-being. The results are clear and comprehensive, the discussion is based on very recent and well written articles. 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

  1. The study enumerating the protective effects of nimodipine against cisplatin induced toxicity has been reviewed.
  2. The work overall neat and free from major technical errors.
  3. The section 2.5 needs to be written more clearly with regards to the treatment inductions. I believe that this section is partly confusing for the readers. 
  4. I can recommend the current article with minor revisions.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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