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Volume 24
Issue 15
10.3390/ijms241512421
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Article
Peer-Review Record

Polystyrene Microplastics Exacerbate Systemic Inflammation in High-Fat Diet-Induced Obesity

Int. J. Mol. Sci. 2023, 24(15), 12421; https://doi.org/10.3390/ijms241512421
by Aden Geonhee Lee 1,†, Sora Kang 2,†, Hye Ji Yoon 2, Suyeol Im 3, Seung Jun Oh 3 and Youngmi Kim Pak 2,3,4,*
Reviewer 1:
Ekaterina Georgieva
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(15), 12421; https://doi.org/10.3390/ijms241512421
Submission received: 15 July 2023 / Revised: 31 July 2023 / Accepted: 2 August 2023 / Published: 4 August 2023
(This article belongs to the Special Issue Environmental and Human Adverse Effects of Micro and Nanoplastics)

Round 1

Reviewer 1 Report

The present paper aims to evaluate the effect of microplastic polymers on obesity-related circulating inflammatory immune cells, glucose metabolism, insulin resistance, and an increased level of inflammation response in various tissues during high-fat diet conditions. 

The authors found that styrene exhibits the highest binding affinity to BV2 microglial cells and immune cells, increasing the levels of Ly6Chigh inflammatory monocytes in blood and inflammatory CD11c+ macrophages. Under high fat or cholesterol diet, fPS-MPs including microparticles with a size of 1.0 µm cross the blood-brain barrier and accumulate in the whole brain region, which can determine their detection throughout the brain. This result may initiate an exacerbation of brain neuroinflammation in the HFD-induced obese mice model by directly activating microglia and indirectly recruiting peripheral macrophages. Also, the results show that oral administration of fPS-MPs exacerbates abnormal fat accumulation by impairing glucose metabolism and potentiating insulin resistance.

This is a very interesting study that highlights the role of fPS-MPs in the initiation of systemic Inflammation in HFD-induced obesity. The results are well-presented and the manuscript is comprehensive. 

It was found Minor grammatical errors in the text. Check and correct it.

Author Response

Thank you for your generous review. English was checked and revised by native English speaker.

Reviewer 2 Report

Authors conducted a comprehensive investigation utilizing in silico, in vitro, and in vivo approaches to explore the brain distribution and physiological effects of MPs. Their findings suggest that PS-MPs significantly contribute to the exacerbation of systemic inflammation in high fat diet-induced obesity by activating peripheral and central inflammatory immune cells.

Overall I found the study well designed and executed properly. Some minor changes are highlighted in attached file.

Comments for author File: Comments.pdf

Author Response

Thank you. I am sorry that I can not see any highlighted changes in the attached file. Would you please send the file again? I will be happy to accept the changes.

I found some editing was done in the manuscript. But I can not make any changes in this pdf file.  Please let me know how to do.

Sincerely,

 

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