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Volume 24
Issue 7
10.3390/ijms24076832
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Communication
Peer-Review Record

Effect of Cytomegalovirus Reactivation on Inflammatory Status and Mortality of Older COVID-19 Patients

Int. J. Mol. Sci. 2023, 24(7), 6832; https://doi.org/10.3390/ijms24076832
by Robertina Giacconi 1,*, Maurizio Cardelli 1, Francesco Piacenza 1, Elisa Pierpaoli 1, Elisabetta Farnocchia 1, MirKo Di Rosa 2, Anna Rita Bonfigli 3, Tiziana Casoli 4, Francesca Marchegiani 5, Fiorella Marcheselli 5, Rina Recchioni 5, Pierpaolo Stripoli 5, Roberta Galeazzi 6, Antonio Cherubini 7, Massimiliano Fedecostante 7, Riccardo Sarzani 8,9, Chiara Di Pentima 8,9, Piero Giordano 8,9, Roberto Antonicelli 10, Mauro Provinciali 1 and Fabrizia Lattanzio 3add Show full author list remove Hide full author list
Reviewer 1:
Giau Van Vo
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2023, 24(7), 6832; https://doi.org/10.3390/ijms24076832
Submission received: 18 January 2023 / Revised: 16 March 2023 / Accepted: 30 March 2023 / Published: 6 April 2023
(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Round 1

Reviewer 1 Report

Since the CMV has been previously described in severe COVID-19. The present study revealed that the older COVID-19 patients may present CMV reactivation which could aggravate the disease course, influencing IFN-α and TNF-α production and increasing the risk of in-hospital death in elderly octogenarian patients. Despite it is an interesting manuscript. There are some concerns that need to be further investigated. 

1. Previously, one third of patients (about 70%) in intensive care reactivate CMV, which doubles their mortality rate; in this study, how many COVID-19 patients reactivate latent CMV to complicate their diseases and enhance their mortality rate? not well described

2. A  larger patient cohort needed to perform to verify their data

3. Methods for CMV testing should include testing for CMV IgM, and preferably examination of a tissue sample by immunostaining for CMV, in comparion with and without COVID-19

Author Response

Please see the attachment.

Author Response File: Author Response.pdf

Reviewer 2 Report

This manuscript exploited the relationship of cytomegalovirus (CMV) reactivation with the inflammatory status and the result of older patients infected with COVID-19, and found CMV reactivation is an independent risk factor. These results would be value of guide for the therapy of COVID-19 older patients.   

The manuscript is interesting. However, a few comments should be addressed to improve the manuscript.

Comments:

1. Line 45,46: The format of comma seems not to be correct.

2.Line 81, 109…: the “P” should be italicized.

3. Line 107, 110: Table 2 and Table 3 should be three-line grid .

4. Line 113: This figure is loss of Y axis.

Author Response

Please see the attachment

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

Thanks for the revised manuscript. There is no further comment. It can be now acceptable!

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