Next Article in Journal
Conditional Knockout Kdm2a Reveals Crucial Involvement in Development and Function of Kidney Collecting Ducts
Previous Article in Journal
Role of TRP Channels in Cancer-Induced Bone Pain
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 26
Issue 3
10.3390/ijms26031231
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia

by
Estrella Gómez-Tortosa
1,2,*,
Pablo Agüero-Rabes
1,
Alicia Ruiz-González
3,
Sonia Wagner-Reguero
3,
Raquel Téllez
4,
Ignacio Mahillo
5,
Andrea Ruiz-Calvo
3,
María José Sainz
1,
Anna Lena Nystrom
1,
Teodoro del Ser
3 and
Pascual Sánchez-Juan
3
1
Department of Neurology, Fundación Jiménez Díaz, Madrid 28040, Spain
2
Instituto de Investigación Sanitaria, Fundación Jiménez Díaz (IIS-FJD), Madrid 28040, Spain
3
Alzheimer’s Centre Reina Sofía-CIEN Foundation, Instituto de Salud Carlos III, Madrid 28031, Spain
4
Department of Immunology, Fundación Jiménez Díaz, Madrid 28040, Spain
5
Department of Biostatistics and Epidemiology, Fundación Jiménez Díaz, Madrid 28040, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2025, 26(3), 1231; https://doi.org/10.3390/ijms26031231
Submission received: 20 December 2024 / Revised: 20 January 2025 / Accepted: 21 January 2025 / Published: 30 January 2025
(This article belongs to the Section Molecular Neurobiology)
Versions Notes

Abstract

Plasma biomarkers are promising tools for the screening and diagnosis of dementia in clinical settings. We analyzed plasma levels of Alzheimer’s core biomarkers, neurofilament light chain (NfL) and glial fibrillary acid protein (GFAP), through single-molecule Array in 108 patients with Alzheimer’s (AD, cerebrospinal fluid with an amyloid+ tau+ neurodegeneration+ profile), 73 patients with frontotemporal dementia (FTD, 24 with genetic diagnosis), and 54 controls. The best area under the curve (AUC) was used to assess the discriminative power. Patients with AD had lower Aß42/40 ratios and NfL levels, along with higher levels of p-tau181 and GFAP, compared with FTD patients. Single biomarkers discriminated well between dementia patients and controls: the Aß42/40 ratio (AUC:0.86) or GFAP (AUC:0.83) was found for AD, and the NfL (AUC:0.84) was found for FTD patients. However, a combination of two (NfL with p-tau181, or the GFAP/NfL ratio, AUCs ~0.87) or three biomarkers (NfL, P-tau181, and Aß42/40 ratio, AUC: 0.90) was required to distinguish between AD and FTD. Biomarker profiles were similar across different FTD phenotypes, except for carriers of PGRN mutations, who had higher levels of NfL than C9orf72 expansion carriers. In our series, NfL alone provided the best distinction between FTD and controls, while a combination of two or three biomarkers was required to obtain good discrimination between AD and FTD.
Keywords: plasma biomarkers; Alzheimer’s disease; frontotemporal dementia; SIMOA; neurofilament light chain; glial fibrillary acid protein plasma biomarkers; Alzheimer’s disease; frontotemporal dementia; SIMOA; neurofilament light chain; glial fibrillary acid protein

Share and Cite

MDPI and ACS Style

Gómez-Tortosa, E.; Agüero-Rabes, P.; Ruiz-González, A.; Wagner-Reguero, S.; Téllez, R.; Mahillo, I.; Ruiz-Calvo, A.; Sainz, M.J.; Nystrom, A.L.; del Ser, T.; et al. Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia. Int. J. Mol. Sci. 2025, 26, 1231. https://doi.org/10.3390/ijms26031231

AMA Style

Gómez-Tortosa E, Agüero-Rabes P, Ruiz-González A, Wagner-Reguero S, Téllez R, Mahillo I, Ruiz-Calvo A, Sainz MJ, Nystrom AL, del Ser T, et al. Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia. International Journal of Molecular Sciences. 2025; 26(3):1231. https://doi.org/10.3390/ijms26031231

Chicago/Turabian Style

Gómez-Tortosa, Estrella, Pablo Agüero-Rabes, Alicia Ruiz-González, Sonia Wagner-Reguero, Raquel Téllez, Ignacio Mahillo, Andrea Ruiz-Calvo, María José Sainz, Anna Lena Nystrom, Teodoro del Ser, and et al. 2025. "Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia" International Journal of Molecular Sciences 26, no. 3: 1231. https://doi.org/10.3390/ijms26031231

APA Style

Gómez-Tortosa, E., Agüero-Rabes, P., Ruiz-González, A., Wagner-Reguero, S., Téllez, R., Mahillo, I., Ruiz-Calvo, A., Sainz, M. J., Nystrom, A. L., del Ser, T., & Sánchez-Juan, P. (2025). Plasma Biomarkers in the Distinction of Alzheimer’s Disease and Frontotemporal Dementia. International Journal of Molecular Sciences, 26(3), 1231. https://doi.org/10.3390/ijms26031231

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop