6,8-Dibromo-11H-indeno[1,2-b]quinolin-11-one

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

In this paper, the authors describe the synthesis of a new indenoquinolin derivative using the Friedländer reaction. The new product is well-characterized. I suggest the authors have the manuscript checked by a native English speaker before publication. Just a few notes:

1) Why did the authors attempt the reaction in water, knowing they would face solubility issues with the starting substrates?

2) In the abstract, it is recommended to remove any numerical references to compounds;

3) At line 57, the authors do not specify which derivative they intend to synthesize;

4) Line 60 is Results and Discussion;

5) Scheme 3 is a litte bit confusing. a) and b) are not two consecutive reaction steps but two different reaction pathways. Please fix.

 

Comments on the Quality of English Language

I suggest the authors have the manuscript checked by a native English speaker before publication

Author Response

Comment 1: In this paper, the authors describe the synthesis of a new indenoquinolin derivative using the Friedländer reaction. The new product is well-characterized. I suggest the authors have the manuscript checked by a native English speaker before publication. Just a few notes:

Response 1: The authors thank the reviewer for valuable comments. The text of the manuscript was checked by a native speaker and corrected.

Comment 2: Why did the authors attempt the reaction in water, knowing they would face solubility issues with the starting substrates?

Response 2: We are grateful to the reviewer for this comment. In the revised version of the manuscript, the reaction in water was not declared as a separate synthetic route. We just mentioned in the text about a low conversion of the starting materials in water.

Comment 3: In the abstract, it is recommended to remove any numerical references to compounds;

Response 3: The numerical references were removed from Abstract.

Comment 4: At line 57, the authors do not specify which derivative they intend to synthesize;

Response 4: The compound name was added.

Comment 5: Line 60 is Results and Discussion;

Response 5: This was corrected.

Comment 6: Scheme 3 is a litte bit confusing. a) and b) are not two consecutive reaction steps but two different reaction pathways. Please fix.

Response 6: We thank the reviewer for this comment. The text “a, b” was removed from Scheme 3.

Reviewer 2 Report

Comments and Suggestions for Authors

This contribution reports the synthesis of the compound 6,8-dibromo-11H-indeno[1,2-b]quinoline-11-one, which is promising for pharmaceutical applications. The structure of the compound was confirmed by single crystal X-ray diffraction. I recommend to accept after one minor revision. Please find the following comment for revision.

1)      Figures 1b and 1c are comparable and show the same interactions. Additionally, the authors describe π-π stacking interactions, but Figure 1c does not effectively show π interaction stacking. The packing could be improved to better identify π-π stacking by using a different angle.

Author Response

Comment 1: Figures 1b and 1c are comparable and show the same interactions. Additionally, the authors describe π-π stacking interactions, but Figure 1c does not effectively show π interaction stacking. The packing could be improved to better identify π-π stacking by using a different angle.

Response 1: We thank the reviewer for this suggestion. Figure 1b was modified to show both types of interactions, π-π stacking interactions are highlighted separately.