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Volume 32
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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

Genetic Regulation of Streptococci by Small RNAs

by
Ye Tu
1,
Xiaoyue Jia
1,
Ran Yang
2,
Xian Peng
1,3,
Xuedong Zhou
1,3 and
Xin Xu
1,3,*
1
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China
2
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China
3
Clinical Research Center for Oral Diseases, Chengdu, Sichuan Province, China
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2019, 32(1), 39-86; https://doi.org/10.21775/cimb.032.039
Submission received: 13 March 2019 / Revised: 10 April 2019 / Accepted: 12 May 2019 / Published: 5 June 2019
Versions Notes

Abstract

Streptococcal species constitute a large group of commensal and pathogenic Gram-positive bacteria that exist in a wide variety of habitats. The family of small RNAs is typically ranged in size from 50 to 300 nucleotides, and acts as regulators in bacteria. The last decade has witnessed the increasing findings of small RNAs (sRNAs), which play important regulatory roles in the variety of biological processes in streptococci. In this review, we summarized the recent achievements in the identification of streptococcal sRNAs, mainly in Streptococcus pyogenes and Streptococcus pneumoniae. In addition, we particularly focused on the functions that sRNAs exert in the regulatory networks of both phenotypical traits and pathogenicity. The fact that sRNAs act as a critical fine-tuning regulator of streptococci may not only reveal in-depth mechanisms of bacterial post-transcriptional regulations in response to environmental perturbance, but also provide promising approaches to the better management of streptococcal infections.
Keywords: Streptococci; small RNA; gene expression; pathogenicity; virulence Streptococci; small RNA; gene expression; pathogenicity; virulence

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MDPI and ACS Style

Tu, Y.; Jia, X.; Yang, R.; Peng, X.; Zhou, X.; Xu, X. Genetic Regulation of Streptococci by Small RNAs. Curr. Issues Mol. Biol. 2019, 32, 39-86. https://doi.org/10.21775/cimb.032.039

AMA Style

Tu Y, Jia X, Yang R, Peng X, Zhou X, Xu X. Genetic Regulation of Streptococci by Small RNAs. Current Issues in Molecular Biology. 2019; 32(1):39-86. https://doi.org/10.21775/cimb.032.039

Chicago/Turabian Style

Tu, Ye, Xiaoyue Jia, Ran Yang, Xian Peng, Xuedong Zhou, and Xin Xu. 2019. "Genetic Regulation of Streptococci by Small RNAs" Current Issues in Molecular Biology 32, no. 1: 39-86. https://doi.org/10.21775/cimb.032.039

APA Style

Tu, Y., Jia, X., Yang, R., Peng, X., Zhou, X., & Xu, X. (2019). Genetic Regulation of Streptococci by Small RNAs. Current Issues in Molecular Biology, 32(1), 39-86. https://doi.org/10.21775/cimb.032.039

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