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Current Oncology
Volume 15
Issue 2
10.3747/co.v15i2.245
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

Predictors of Positive Radial Margin Status in a Population-Based Cohort of Patients with Rectal Cancer

by
P.T. Phang
*,
H. Kennecke
,
C.E. McGahan
,
J. MacFarlane
,
G. McGregor
and
J.H. Hay
St. Paul’s Hospital, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2008, 15(2), 98-103; https://doi.org/10.3747/co.v15i2.245
Submission received: 1 April 2008 / Revised: 1 April 2008 / Accepted: 1 April 2008 / Published: 1 April 2008

Abstract

Background: Surgical margin status is an important predictor of risk of relapse among patients with rectal cancer. Methods: Patients referred to the British Columbia Cancer Agency for consideration of adjuvant therapy for rectal adenocarcinoma were included. Predictors of margin positivity were determined from uni- and multivariate analysis. Results: Among 340 patients, 83% had negative resection margins. In 268 patients with resectable tumours, a significantly higher rate of margin positivity was observed in low rectal tumours (32.2%) as compared with midrectal (3.9%) and high rectal (14.3%) tumours. Among 59 patients with locally advanced rectal cancer treated with preoperative radiation (with or without chemotherapy), 32% with low tumours had margin positivity. Of patients with T4 tumours, 50% (11/22) had a positive resection margin. Conclusions: In a population cohort, distal-third rectal location, locally advanced presentation, and T4 cancer represent subgroups for whom further improvement in therapy is required.
Keywords: rectal cancer; predictors of surgical margin status rectal cancer; predictors of surgical margin status

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MDPI and ACS Style

Phang, P.T.; Kennecke, H.; McGahan, C.E.; MacFarlane, J.; McGregor, G.; Hay, J.H. Predictors of Positive Radial Margin Status in a Population-Based Cohort of Patients with Rectal Cancer. Curr. Oncol. 2008, 15, 98-103. https://doi.org/10.3747/co.v15i2.245

AMA Style

Phang PT, Kennecke H, McGahan CE, MacFarlane J, McGregor G, Hay JH. Predictors of Positive Radial Margin Status in a Population-Based Cohort of Patients with Rectal Cancer. Current Oncology. 2008; 15(2):98-103. https://doi.org/10.3747/co.v15i2.245

Chicago/Turabian Style

Phang, P.T., H. Kennecke, C.E. McGahan, J. MacFarlane, G. McGregor, and J.H. Hay. 2008. "Predictors of Positive Radial Margin Status in a Population-Based Cohort of Patients with Rectal Cancer" Current Oncology 15, no. 2: 98-103. https://doi.org/10.3747/co.v15i2.245

APA Style

Phang, P. T., Kennecke, H., McGahan, C. E., MacFarlane, J., McGregor, G., & Hay, J. H. (2008). Predictors of Positive Radial Margin Status in a Population-Based Cohort of Patients with Rectal Cancer. Current Oncology, 15(2), 98-103. https://doi.org/10.3747/co.v15i2.245

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