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Current Oncology
Volume 15
Issue 5
10.3747/co.v15i5.252
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Current Oncology is published by MDPI from Volume 28 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Multimed Inc..
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Article

The Confused Cancer Patient: A Case of 5-Fluorouracil—Induced Encephalopathy

by
W. Y. Cheung
1,
R. A. Fralick
2 and
S. Cheng
1,2,3,*
1
Department of Medical Oncology and Hematology, University of Toronto, Toronto, ON, Canada
2
Division of Medical Oncology, Odette Cancer Center, Toronto, ON, Canada
3
Odette Cancer Center, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2008, 15(5), 234-236; https://doi.org/10.3747/co.v15i5.252
Submission received: 5 July 2008 / Revised: 6 August 2008 / Accepted: 7 September 2008 / Published: 1 October 2008

Abstract

The fluorinated pyrimidine 5-fluorouracil (5-FU) is an anticancer agent used in most adjuvant and palliative treatment regimens for colorectal cancer. Neurotoxicities are considered extremely rare side effects of 5-FU. Here, we report a case of 5-FU–induced encephalopathy, manifesting as seizures and delirium, in an era of oxaliplatin-containing chemotherapy. If ammonia levels are elevated, lactulose may be considered in the initial management of neuropsychiatric complications from 5-FU.
Keywords: colorectal cancer; 5-fluorouracil; oxaliplatin; chemotherapy; complications colorectal cancer; 5-fluorouracil; oxaliplatin; chemotherapy; complications

Share and Cite

MDPI and ACS Style

Cheung, W.Y.; Fralick, R.A.; Cheng, S. The Confused Cancer Patient: A Case of 5-Fluorouracil—Induced Encephalopathy. Curr. Oncol. 2008, 15, 234-236. https://doi.org/10.3747/co.v15i5.252

AMA Style

Cheung WY, Fralick RA, Cheng S. The Confused Cancer Patient: A Case of 5-Fluorouracil—Induced Encephalopathy. Current Oncology. 2008; 15(5):234-236. https://doi.org/10.3747/co.v15i5.252

Chicago/Turabian Style

Cheung, W. Y., R. A. Fralick, and S. Cheng. 2008. "The Confused Cancer Patient: A Case of 5-Fluorouracil—Induced Encephalopathy" Current Oncology 15, no. 5: 234-236. https://doi.org/10.3747/co.v15i5.252

APA Style

Cheung, W. Y., Fralick, R. A., & Cheng, S. (2008). The Confused Cancer Patient: A Case of 5-Fluorouracil—Induced Encephalopathy. Current Oncology, 15(5), 234-236. https://doi.org/10.3747/co.v15i5.252

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