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Current Oncology
Volume 32
Issue 2
10.3390/curroncol32020062
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Symptoms, Symptom Profiles, and Healthcare Utilization in Patients with Hematologic Malignancies: A Retrospective Observational Cohort Study and Latent Class Analysis

by
Reanne Booker
1,2,*,
Richard Sawatzky
3,4,5,
Aynharan Sinnarajah
6,
Siwei Qi
7,
Claire Link
8,
Linda Watson
8,9 and
Kelli Stajduhar
2
1
Palliative Care, Arthur JE Child Comprehensive Cancer Centre, Calgary, AB T2N 4N1, Canada
2
School of Nursing, University of Victoria, Victoria, BC V8P 5C2, Canada
3
School of Nursing, Trinity Western University, Langley, BC V2Y 1Y1, Canada
4
Centre for Advancing Health Outcomes, St. Paul’s Hospital, Vancouver, BC V6Z 1Y6, Canada
5
University of Gothenburg Centre for Person‑Centred Care (GPCC), Sahlgrenska Academy, University of Gothenburg, SE-405 30 Gothenburg, Sweden
6
Division of Palliative Medicine, Queen’s University, Kingston, ON K7L 3J7, Canada
7
Surveillance & Reporting, Advanced Analytics, Cancer Research & Analytics, Cancer Care Alberta, Alberta Health Services, Calgary, AB T2N 2T9, Canada
8
Supportive Care Services and Patient Experience, Cancer Care Alberta, Alberta Health Services, Calgary, AB T2N 2T9, Canada
9
Faculty of Nursing, University of Calgary, Calgary, AB T2N 1N4, Canada
*
Author to whom correspondence should be addressed.
Curr. Oncol. 2025, 32(2), 62; https://doi.org/10.3390/curroncol32020062
Submission received: 4 December 2024 / Revised: 14 January 2025 / Accepted: 22 January 2025 / Published: 25 January 2025
(This article belongs to the Special Issue Palliative Care and Supportive Medicine in Cancer)
Review Reports Versions Notes

Abstract

Symptom burden is known to be high in patients with hematologic malignancies and can adversely impact patients’ quality of life. The aims of this retrospective observational cohort study were to explore symptoms in patients with hematologic malignancies, including during the last year of life, to explore symptom profiles in patients with hematologic malignancies, and to explore associations among symptoms/symptom profiles and demographic, clinical, and treatment-related variables. Symptom prevalence and severity and symptom profiles were explored in patients with hematologic malignancies who completed patient-reported outcome measures (n = 6136) between October 2019 and April 2020. Emergency department visits and hospital admissions during the study period were reviewed. Chart audits were undertaken for patients who died within a year of completing patient-reported outcome measures (n = 432) to explore symptoms and healthcare utilization in the last year of life. Patients with hematologic malignancies in this study reported multiple symptoms co-occurring, with more than 50% of patients reporting four or more symptoms. Classes of co-occurring symptoms (symptom profiles) were associated with demographic and clinical factors as well as with healthcare utilization, particularly emergency department visits. The most reported symptoms were tiredness, impaired well-being, and drowsiness. The findings emphasize the need for more supports for patients with hematologic malignancies, particularly for symptom management.
Keywords: hematologic malignancies; quality of life; symptom burden; symptom profiles; healthcare utilization; palliative care hematologic malignancies; quality of life; symptom burden; symptom profiles; healthcare utilization; palliative care

Share and Cite

MDPI and ACS Style

Booker, R.; Sawatzky, R.; Sinnarajah, A.; Qi, S.; Link, C.; Watson, L.; Stajduhar, K. Symptoms, Symptom Profiles, and Healthcare Utilization in Patients with Hematologic Malignancies: A Retrospective Observational Cohort Study and Latent Class Analysis. Curr. Oncol. 2025, 32, 62. https://doi.org/10.3390/curroncol32020062

AMA Style

Booker R, Sawatzky R, Sinnarajah A, Qi S, Link C, Watson L, Stajduhar K. Symptoms, Symptom Profiles, and Healthcare Utilization in Patients with Hematologic Malignancies: A Retrospective Observational Cohort Study and Latent Class Analysis. Current Oncology. 2025; 32(2):62. https://doi.org/10.3390/curroncol32020062

Chicago/Turabian Style

Booker, Reanne, Richard Sawatzky, Aynharan Sinnarajah, Siwei Qi, Claire Link, Linda Watson, and Kelli Stajduhar. 2025. "Symptoms, Symptom Profiles, and Healthcare Utilization in Patients with Hematologic Malignancies: A Retrospective Observational Cohort Study and Latent Class Analysis" Current Oncology 32, no. 2: 62. https://doi.org/10.3390/curroncol32020062

APA Style

Booker, R., Sawatzky, R., Sinnarajah, A., Qi, S., Link, C., Watson, L., & Stajduhar, K. (2025). Symptoms, Symptom Profiles, and Healthcare Utilization in Patients with Hematologic Malignancies: A Retrospective Observational Cohort Study and Latent Class Analysis. Current Oncology, 32(2), 62. https://doi.org/10.3390/curroncol32020062

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