Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Nicotine Increases HIV-1 Infection and Alters Immune Cell Profiling
3.2. HIV and Nicotine Co-Exposure Amplifies Inflammasome Activation and Immune Responses
3.3. Nicotine and HIV Enhance Oxidative Stress and Mitochondrial Dysfunction
3.4. HIV and Nicotine Synergistically Impact Oxidative Phosphorylation and the NLRP3 Inflammasome
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Schrode, N.; Fortune, T.; Keane, A.M.; Mangold, J.F.; Tweel, B.; Beaumont, K.G.; Swartz, T.H. Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation. Viruses 2024, 16, 1797. https://doi.org/10.3390/v16111797
Schrode N, Fortune T, Keane AM, Mangold JF, Tweel B, Beaumont KG, Swartz TH. Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation. Viruses. 2024; 16(11):1797. https://doi.org/10.3390/v16111797
Chicago/Turabian StyleSchrode, Nadine, Trinisia Fortune, Aislinn M. Keane, Jesse F. Mangold, Benjamin Tweel, Kristin G. Beaumont, and Talia H. Swartz. 2024. "Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation" Viruses 16, no. 11: 1797. https://doi.org/10.3390/v16111797
APA StyleSchrode, N., Fortune, T., Keane, A. M., Mangold, J. F., Tweel, B., Beaumont, K. G., & Swartz, T. H. (2024). Single-Cell Transcriptomics of Human Tonsils Reveals Nicotine Enhances HIV-1-Induced NLRP3 Inflammasome and Mitochondrial Activation. Viruses, 16(11), 1797. https://doi.org/10.3390/v16111797