Next Article in Journal
A Rare Gastrointestinal Manifestation of Systemic Primary Amyloidosis
Previous Article in Journal
Alteration in Transforming Growth Factor-β Receptor Expression in Gallbladder Disease: Implications of Chronic Cholelithiasis and Chronic Salmonella Typhi Infection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Gastroenterology Insights
Volume 7
Issue 1
10.4081/gi.2016.6641
gastroent-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
Gastroenterology Insights is published by MDPI from Volume 11 Issue 1 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Prognostic and Predictive Roles of microRNA-383 in Colorectal Cancer

by
Alavieh Fateh
1,
Mohammad Ali Hosseinpour Feizi
1,*,
Reza Safaralizadeh
1,
Mohammad Hossein Somi
2,
Reyhaneh Ravanbakhsh
1,
Behrouz Shokoohi
3,
Shahryar Hashemzadeh
4 and
Shirin Azarbarzin
1
1
Department of Animal Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran
2
Liver and Gastroenterology Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3
Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
4
Department of General and Thoracic Surgery, Tabriz University of Medical Sciences, Tabriz, Iran
*
Author to whom correspondence should be addressed.
Gastroenterol. Insights 2016, 7(1), 6641; https://doi.org/10.4081/gi.2016.6641
Submission received: 9 June 2016 / Revised: 10 August 2016 / Accepted: 12 August 2016 / Published: 19 August 2016

Abstract

MicroRNAs (miRNAs) are impressive regulators of gene expression that have a critical role in the pathogenesis of colorectal cancer (CRC). With respect to the aberrant expression of miRNA-383 (miR-383) in some types of human malignancy, this prospective study characterized its contribution to CRC tumorigenesis. The real-time reverse transcriptionpolymerase chain reaction was used to examine miR-383 expression levels prospectively in 40 sample pairs of CRC tissues and adjacent noncancerous tissues (>2 cm from cancer tissue). No significant relationship was found between miR-383 expression levels and clinicopathological features. The ability of miR-383 to function as a tumor marker was also examined. Showing significant changes overall, miR-383 expression levels were significantly down regulated in the group of CRC samples compared with matched noncancerous tissue samples. A receiver-operating characteristic (ROC) curve also showed ROC area of 70% for miR-383 with 68 and 75% sensitivity and specificity, respectively. Therefore, miR-383 can be considered as a tumor marker in CRC and help as a potential predictive biomarker in the diagnosis of colorectal cancer.
Keywords: biomarker; colorectal cancer; microRNA; miR-383 biomarker; colorectal cancer; microRNA; miR-383

Share and Cite

MDPI and ACS Style

Fateh, A.; Hosseinpour Feizi, M.A.; Safaralizadeh, R.; Somi, M.H.; Ravanbakhsh, R.; Shokoohi, B.; Hashemzadeh, S.; Azarbarzin, S. Prognostic and Predictive Roles of microRNA-383 in Colorectal Cancer. Gastroenterol. Insights 2016, 7, 6641. https://doi.org/10.4081/gi.2016.6641

AMA Style

Fateh A, Hosseinpour Feizi MA, Safaralizadeh R, Somi MH, Ravanbakhsh R, Shokoohi B, Hashemzadeh S, Azarbarzin S. Prognostic and Predictive Roles of microRNA-383 in Colorectal Cancer. Gastroenterology Insights. 2016; 7(1):6641. https://doi.org/10.4081/gi.2016.6641

Chicago/Turabian Style

Fateh, Alavieh, Mohammad Ali Hosseinpour Feizi, Reza Safaralizadeh, Mohammad Hossein Somi, Reyhaneh Ravanbakhsh, Behrouz Shokoohi, Shahryar Hashemzadeh, and Shirin Azarbarzin. 2016. "Prognostic and Predictive Roles of microRNA-383 in Colorectal Cancer" Gastroenterology Insights 7, no. 1: 6641. https://doi.org/10.4081/gi.2016.6641

APA Style

Fateh, A., Hosseinpour Feizi, M. A., Safaralizadeh, R., Somi, M. H., Ravanbakhsh, R., Shokoohi, B., Hashemzadeh, S., & Azarbarzin, S. (2016). Prognostic and Predictive Roles of microRNA-383 in Colorectal Cancer. Gastroenterology Insights, 7(1), 6641. https://doi.org/10.4081/gi.2016.6641

Article Metrics

Back to TopTop