Next Article in Journal
Waist Circumference and Abdominal Volume Index Can Predict Metabolic Syndrome in Adolescents, but only When the Criteria of the International Diabetes Federation are Employed for the Diagnosis
Next Article in Special Issue
Modelling the Effect of Compliance with Nordic Nutrition Recommendations on Cardiovascular Disease and Cancer Mortality in the Nordic Countries
Previous Article in Journal
Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer
Previous Article in Special Issue
Protein-Reduced Complementary Foods Based on Nordic Ingredients Combined with Systematic Introduction of Taste Portions Increase Intake of Fruits and Vegetables in 9 Month Old Infants: A Randomised Controlled Trial
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Nutrients
Volume 11
Issue 6
10.3390/nu11061369
nutrients-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Nordic Diet and Inflammation—A Review of Observational and Intervention Studies

by
Maria Lankinen
1,*,
Matti Uusitupa
1 and
Ursula Schwab
1,2
1
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70211 Kuopio, Finland
2
Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, 70210 Kuopio, Finland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1369; https://doi.org/10.3390/nu11061369
Submission received: 11 April 2019 / Revised: 7 June 2019 / Accepted: 14 June 2019 / Published: 18 June 2019
(This article belongs to the Special Issue Health Benefits of the Nordic Diet)
Browse Figures
Review Reports Versions Notes

Abstract

:
Low-grade inflammation (LGI) has been suggested to be involved in the development of chronic diseases. Healthy dietary patterns, such as the Mediterranean diet (MD), may decrease the markers of LGI. Healthy Nordic diet (HND) has many similarities with MD, but its effects on LGI are less well known. Both of these dietary patterns emphasize the abundant use of fruits and vegetables (and berries in HND), whole grain products, fish, and vegetable oil (canola oil in HND and olive oil in MD), but restrict the use of saturated fat and red and processed meat. The aim of this narrative review is to summarize the results of studies, which have investigated the associations or effects of HND on the markers of LGI. Altogether, only two publications of observational studies and eight publications of intervention trials were found through the literature search. Both observational studies reported an inverse association between the adherence to HND and concentration of high sensitivity C-reactive protein (hsCRP). A significant decrease in the concentration of hsCRP was reported in two out of four intervention studies measuring hsCRP. Single intervention studies reported the beneficial effects on interleukin 1Ra and Cathepsin S. Current evidence suggests the beneficial effects on LGI with HND, but more carefully controlled studies are needed to confirm the anti-inflammatory effects of the HND.

1. Introduction

Low-grade inflammation (LGI) has been linked with the pathogenesis of several chronic diseases, such as cardiovascular diseases, type 2 diabetes, certain cancers, and neurodegenerative diseases [1,2,3,4]. It is well known that human adipose tissue is not only a storage for excess energy, but it is also an active endocrine organ producing and releasing a number of bioactive compounds, adipokines, of which some are known to be pro-inflammatory (e.g., tumor necrosis factor alfa (TNF-α), Interleukins (IL) 6 and 8), and some anti-inflammatory (e.g., adiponectin) [5,6]. Besides adipose tissue, white blood cells (e.g., monocytes), macrophages, and the liver produce pro- and anti-inflammatory factors [7,8]. It has also been suggested that there is an interaction between the gut microbiota and the immune system, and changes in the gut microbiota may contribute to LGI by resulting in a deficient immune response and impaired tolerance to commensal microorganisms [9,10]. Various mechanisms through which LGI may contribute to the development of non-communicable diseases have been discussed in several reviews [3,6,7,11].
Obesity, especially abdominal obesity and the accumulation of visceral fat, is associated with LGI, and weight loss is the key treatment for LGI in overweight and obese people [12]. Weight loss decreases the elevated concentrations of plasma inflammatory markers and increases e.g., low levels of anti-inflammatory adiponectin [12,13,14,15]. However, the quality of diet and its individual components may also affect the concentrations of inflammatory markers, regardless of weight loss [12]. Especially the Mediterranean diet and some other healthy dietary patterns have been shown to decrease the markers of LGI [16,17]. Those dietary patterns have been characterized as plant food based ones (mostly fruit, vegetables and whole grain, and with a little red meat) [16].
Healthy Nordic diet (HND) has many similarities with the Mediterranean diet [18]. Both dietary patterns emphasize the abundant use of fruits and vegetables, whole grain products, and fish, but will restrict the use of saturated fat (milk fat) and red and processed meat. Olive oil is an important source for unsaturated fat in the Mediterranean diet, whereas canola oil is used in the HND. The HND includes also local berries, like bilberries, lingonberries, and strawberries [18]. There is some variation in the HND between the different Nordic countries and regions, e.g., in consumed fish species and types of berries, fruits, vegetables, and bread.
Recently, Kaluza and colleagues developed a questionnaire-based Anti-Inflammatory Diet Index (AIDI), which could predict systemic chronic inflammation in the Nordic population [19]. It was based on a 123-item food frequency questionnaire among 3503 women with high sensitivity C reactive protein (hsCRP) plasma concentration <20 mg/L. Altogether, 20 foods were statistically significantly related to hsCRP. Foods with anti-inflammatory potential were fruits and vegetables, tea, coffee, whole-grain bread, breakfast cereal, low-fat cheese, chocolate, dried fruits, herbal tea, olive and canola oils, legumes, nuts, linseeds, red wine, and beer. Foods with pro-inflammatory potential were unprocessed red meat, processed meat, organ meat, chips, and soft-drink beverages. This study did not investigate the complete dietary pattern, but hypothesized that these foods might be related to LGI, especially in the Nordic population.
The aim of this narrative review is to summarize the results of studies, which have investigated the associations or the effects of the HND on markers of LGI in observational and intervention studies, respectively. There are several different biomarkers that are used for assessing LGI in dietary studies. In these studies, the markers have been CRP, hsCRP, IL-6, IL-1 Ra, leptin, high-molecular weight adiponectin, TNF-α, IL-1β, IL-10, TNF RII, and Chatepsin S. Furthermore, inflammation on the level of expression of genes that are linked to inflammation in adipose tissue and peripheral blood mononuclear cells (PBMC) is an interesting approach to examine the impact of diet on LGI in the target tissues [20,21].

2. Methods

We carried out a literature search of the Nordic diet and LGI and related biomarkers in PubMed. We used the following search term: (Nordic diet OR Baltic sea diet) AND (inflammation OR biomarker OR metabolomics) AND human NOT animal. The search was performed until the 30th of April 2019 and it gave, altogether, 38 publications. Relevant articles were selected based on the review of the abstracts (Figure 1). All of the studies that were related to the topic were included in this review. There were two publications reporting results from observational studies [22,23] (Table 1 and Table 2A) and three publications from intervention studies from two different interventions, SYSDIET [20,24] and New Nordic Diet [25] (Figure 1, Table 1 and Table 2B). In addition, we included three intervention studies that reported the effects of the HND on LGI related markers, but were not encompassed by the search. They were the NORDIET intervention [26,27] and the New Nordic Diet intervention [28]. We also included the SYSDIMET intervention trial, which included three key Nordic food items, i.e., fatty fish, bilberries, and whole grain rye products in line with HND pattern [29] and new publication from the SYSDIET study samples investigating gene-expression in PBMCs [30]. Altogether, there were two publications from three observational studies and eight publications from four intervention studies (Figure 1, Table 1 and Table 2).

3. HND and LGI in Observational Studies

Thus far, there are two observational studies (including data from three cohorts) investigating the association between the HND (named as the Baltic Sea Diet in these studies, which corresponds the same as HND) and LGI. Those studies have consistently shown an inverse association between the HND and hsCRP (Table 2A).
The association between the HND and inflammatory markers was independently investigated in two large cross-sectional studies in Finnish participants: in the DIetary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome (DILGOM) study (n = 4579), and in the Helsinki Birth Cohort Study (HBCS, n = 1911) [23]. In both studies, the participants filled in a standardized and validated food frequency questionnaire (FFQ) that was designed to measure the habitual diet over the previous 12 months. Baltic Sea Dietary Score (BSDS), which reflects the HND (score from 0 to 25), was calculated based on the FFQ, and it included nine dietary features: (1) Nordic fruits (apples, pears, and berries); (2) Nordic vegetables (tomatoes, cucumber, leafy vegetables, roots, cabbages, peas); (3) Nordic cereals (rye, oat, and barley); (4) low-fat and fat-free milk; (5) Nordic fish (salmon and freshwater fish); (6) ratio of PUFA to SFA and trans-fatty acids; (7) low intake of red and processed meat; (8) total fat (as % of total energy); and, (9) moderate or low intake of alcohol. The higher the BSDS the better the adherence to the HND. LGI was measured using the following inflammatory markers: leptin, high-molecular weight (HMW) adiponectin, TNF-alfa, IL-6, and hsCRP. In the Determinants of Obesity and Metabolic Syndrome (DILGOM) study, hsCRP concentrations inversely associated with the BSDS (p < 0.01) in all adjusted models, which included relevant confounding factors, such as age, sex, energy intake, education, smoking, physical activity, waist circumference, medication for diabetes, and the use of statins. Participants’ mean concentration of hsCRP was 1.14 mg/L in the lowest BSDS quintile and 1.03 mg/L in the highest BSDS quintile. Unexpectedly, HMW-adiponectin concentrations also inversely associated with the BSDS (p < 0.05). Adjustments for the above-mentioned confounding factors strengthened this association (p < 0.01). Other measured inflammatory markers did not associate with BSDS in the DILGOM study. Alcohol intake was the only component that significantly associated with the HMW-adiponectin concentrations of the single BSDS components. Participants with a high intake of alcohol had higher HMW-adiponectin concentration than individuals with low alcohol intake (p < 0.001). This finding is consistent with earlier findings that were related to alcohol consumption and adiponectin [31]. In the HBCS, the hsCRP inversely associated with the BSDS in all adjusted models (p < 0.01). Other measured inflammatory markers did not associate with BSDS in the HBCS study. Among the single BSDS components, the higher intake of Nordic fruits, berries, and cereals, and the lower intake of red and processed meat and moderate alcohol intake significantly associated with lower hsCRP concentrations in both of the studies.
Both the DILGOM and the HBCS study were included among the Health 2000 Survey in the meta-analysis investigating associations with BSDS and cardiometabolic risk factors, including hsCRP [22] (Table 2A). In this meta-analysis, the risk of elevated hsCRP concentration was lower both among men (OR 0.58, 95% CI 0.43, 0.78) and women (OR 0.73, 95% CI 0.58, 0.91) in the highest BSDS quintile than among those in the lowest BSDS quintile.
In summary, it has been consistently shown that a high adherence to the HND lowers the risk of low-grade inflammation, but, so far, the studies are scarce and only conducted among Finns.

4. Nordic Diet and LGI in Randomized Dietary Trials

4.1. Studies Including Selected Key Components of the HND

Only three intervention studies have investigated the effects of the HND pattern on LGI (Table 2B). Furthermore, the effect of the selected key components of the HND on LGI has been studied in several randomized dietary trials. For example, bilberries, which are rich in phenolic compounds [32] and commonly used in the Nordic countries, decreased the inflammatory score, which was calculated based on concentrations of hsCRP, IL-6, IL-12 and LPS, during the 8-week intervention period [33]. We investigated the effect of low insulin response grain products (including rye bread, sourdough whole grain wheat bread, and dark pasta), fatty fish, and bilberries on several inflammatory markers in the SYSDIMET intervention [29]. Altogether, 104 participants with characteristics of metabolic syndrome who had completed the study were analyzed. The study participants were randomized for 12 weeks into one of three dietary groups: (1) a Healthy Diet group (included whole grain and low insulin response grain products, fish and bilberries), (2) Whole Grain Enriched Diet group (WGED), and (3) control diet group (included refined cereal products and limited fish and berry consumption). HsCRP, TNF-α, IL-6, IL1Ra serum amyloid A (SAA), chemokine (C-C motif) ligand 5 (CCL5), soluble intercellular cellular adhesion molecule-1 (sICAM-1), and macrophage migration inhibitory factor (MIF) were measured as markers of LGI before and after the intervention. There were no significant differences in the changes in these inflammatory markers, except in hsCRP in the participants, who did not use statins during the intervention. The plasma hsCRP concentrations decreased in individuals following the WGED and Healthy Diet interventions (p < 0.01 and p < 0.05, respectively) and the change in hsCRP in the WGED group was significantly different from that in the control group (p < 0.05) (Figure 2). Interestingly, after the intervention, hsCRP was at the same level as in statin users, who had low levels already in the onset of the study (Figure 2).
The effect of a prudent low-fat breakfast (based on Nordic foods) as compared with usual breakfast was studied in a parallel controlled 12-week study with 79 healthy overweight [34]. The prudent breakfast included oat bran porridge with low-fat milk or yogurt, bilberry or lingonberry jam, whole grain bread, low-fat spread (high in PUFA), poultry or fatty fish, and fruit or berries. Foods were provided ad libitum. CRP and TNF-R2 was significantly decreased by the prudent breakfast when compared with the control breakfast (p < 0.005). The percentual changes in CRP and TNF-R2 between baseline and 12 weeks were +37% for the control breakfast and −30% for the prudent breakfast, and +9% for the control breakfast and +2% for the prudent breakfast, respectively. There were no changes in body weight, but sagittal abdominal diameter, which is a marker of visceral fat, was reduced in the prudent breakfast group.

4.2. HND in Controlled Dietary Trials

The effect of the HND pattern on LGI has been investigated in three randomized controlled trials (Table 2B). In the Dietary Intervention With Shop Model (SHOPUS), the objective was to investigate whether the ad libitum New Nordic Diet (NND) versus Average Danish Diet (ADD) in adults (18–65 y) with central obesity and components of the metabolic syndrome could reduce body weight and improve the risk markers of the metabolic syndrome, type 2 diabetes, and cardiovascular diseases [25,28]. The NND included foods as fruits and vegetables (especially berries, cabbages, root vegetables, and legumes), potatoes, fresh herbs, wild plants, and mushrooms, nuts, whole grain, meats from livestock and game, fish and shellfish, and seaweed [35]. The control ADD was the diet that was typically eaten by the adult Danish population. The decrease in energy intake and weight loss was greater in the NND group as compared with the ADD group. The plasma CRP concentration decreased in the NND group (p = 0.007) [27]. The decrease of CRP attenuated, but remained significant after adjusting for weight loss (p = 0.043). TNF-α was measured for the subset of the study population (n = 64), and it did not change significantly [25]. It is worth knowing that these beneficial results were not sustained in the follow-up of the study [36]. However, higher compliance with NND after the active intervention was associated with less body weight regain [36].
In the NORDIET trial, 88 normal to slightly overweight hyperlipidemic men and women were randomly assigned to ad libitum Nordic prudent diet or a control (habitual) diet for six weeks [26,27]. Altogether, 86 participants completed the study with measurements of circulating CRP and cathepsin S levels. Similarly as in the SHOPUS study, the body weight decreased in the HND group as compared with the controls, despite the ad libitum nature of the HND diet. Cathepsin S is a proteolytic enzyme that has been associated with LGI [37,38]. Compared with a habitual control diet, the HND decreased cathepsin S levels (p = 0.03). However, the decrease was not significant after adjusting for change in body weight and LDL-cholesterol concentration, which may indicate that the decrease of the level of S cathepsin was mediated by weight loss or lowered LDL cholesterol concentration. There were no changes in CRP (p = 0.40) [26].
In the SYSDIET study [24], altogether 200 middle-aged individuals with characteristics of metabolic syndrome and impaired fasting glucose/glucose intolerance were randomized into a HND group or a control group for 18 to 24 weeks in six study centers in Finland (2), Sweden (2), Denmark (1), and Iceland (1). The diets were isocaloric in order to keep body weight unchanged. HND included whole-grain products, local berries, fruits and vegetables, canola oil, three fish meals per week and low-fat dairy products. Compliance to diet was monitored by repeated food diaries and serum phospholipid fatty acid profile [24], and later on by alcylresorcinols (fiber intake) and serum beta-carotene (intake of vegetables) [39]. There were more drop-outs in the control group (27% vs. 7.9%), and 96 subjects in the HND group and 70 subjects in the control group completed the study. Some differences in responses to dietary changes were found across different study centers, but, there was an improved lipid profile with HND when compared to control group, and lipid changes and blood pressure reduction were more beneficial in most compliant participants of the HND group when examined in more detail in relation to compliance. No significant changes were found in the weight or glucose tolerance between the study groups. Among the various inflammatory markers examined (hsCRP, IL-1beta, IL-1Ra, IL-6, IL-10, and TNF RII, HMW adiponectin), only IL-1Ra showed a different response between the diets: it increased in the control group while it remained stable in the HND, and at the end of the study a marked difference was seen in IL-1Ra between the groups. The high intake of saturated fatty acids associated with an increase in IL-1Ra, whereas magnesium intake was inversely related to IL-1Ra, but the association with dietary fiber intake was not significant [24]. These results on IL-1Ra may be of importance, since IL-1Ra is a sensitive marker of insulin resistance and it has been shown to predict type 2 diabetes [40]. HND tended to increase plasmalogens based on the further analyses of the serum samples from the SYSDIET study, while a decreasing trend was found in ceramides in line with anti-oxidative and anti-inflammatory properties of HND [41]. Furthermore, in two sub-studies of the SYSDIET, down-regulations of immune response related genes were reported in adipose tissue [20] and PBMCs [30]. Recently, we found associations between dietary fiber intake, serum indole propionate coming from gut, inflammation, and insulin secretion capacity in the study participants of the Finnish Diabetes Prevention Study followed over 10 years. This suggests an intimate role of dietary fiber in the regulation of glucose metabolism and LGI [42,43].

5. Discussion

A Mediterranean type diet, which is much more studied when compared to Nordic diet, has consistently shown to be anti-inflammatory [17]. Mediterranean and Nordic diets have a lot of common features, including abundant use of fruits and vegetables (and berries in the Nordic Diet), the restricted use of saturated fats (milk fat) and red meat, the use of vegetable oil (olive oil in the Mediterranean diet and canola oil in the Nordic diet), and whole grain products as an important source of dietary fiber [19]. They both emphasize the consumption of fish. Consumed fish species are a bit different, but the fat quality and quantity is about the same. In the Nordic countries, fish species, such as salmon, rainbow trout, Baltic herring, mackerel, saithe, and cod, are consumed. Olive and canola oils differ a bit according to their fatty acid content. Canola oil has lower amounts of saturated and monounsaturated fatty acids and more n-3 and n-6 polyunsaturated fatty acids when compared with olive oil. Despite some differences in the diets, this review suggests that the HND may also have anti-inflammatory effects. Adherence to the Mediterranean diet has not been easy in other parts of the Western world [44]. Therefore, it is important to consider local food culture in health promoting food patterns to help in adherence to the diet. Similar to variations in Mediterranean diet by country, there is also some variation in the HND between the different Nordic countries and regions, e.g., in consumed amount and type of fish, berries, fruits, vegetables, and bread. For example, Finns consume more berries and whole grain rye as compared with others [45], whereas Icelanders and Norwegians consume more fish. Therefore, the HND is not exactly the same among the reported studies and in multicenter study, such as SYSDIET, there is also variation in the diet within the study.
Overall, currently, it is not possible to draw definite conclusions of anti-inflammatory effects of HND, since there are quite few studies investigating this issue. Furthermore, several different markers of inflammation have been applied in the studies. It might be seen as a strength that favorable effects have been seen in the circulating markers of inflammation as well as in gene expression level in adipose tissue and PBMCs [20,30]. Recently, Sakhaei et al. published a systematic review and meta-analysis of randomized controlled clinical trials with regard to the effects of the HND pattern on circulating inflammatory markers. [46]. They concluded that adherence to the Nordic diet pattern does not seem to affect circulating CRP, IL-6, and TNF-α. However, this kind of meta-analysis may have limitations due to different study designs and adherence to diets. Other inflammatory markers were not studied in the meta-analysis. The meta-analysis also included a trial in which HND was used as a control diet for a Paleolithic-type diet, which caused greater weight loss when compared with HND [47,48]. Regarding the study design, that study [47,48] did not really measure the effect of HND on LGI.
All of the studies investigating the health effects of HND, and reported in this review, were conducted in the Nordic countries, which enables a reasonable compliance to the HND in the intervention groups. The control diet was usually the average diet in the Nordic countries. However, as seen e.g., in the SYSDIET study [24], the people volunteering to these studies are generally more aware of the principles of the healthy diet as average people are. Therefore, the change in diet is not very dramatic in the intervention groups and the control participants may need to worsen their diet. Overall, the change to the HND from a more westernized diet means that the nutrient concentration of the diet becomes higher and the diet becomes closer to the current Nordic recommendation for both the nutrient and food intake level [49]. This happened indeed e.g., in the SYSDIET study [24]. Better adherence to HND still increased the differences between HND and the average control diet in the SYSDIET study [40].
One limitation in these studies is that there was a significant weight loss during the intervention in some of these [26,28]. These studies do not make it possible to examine the effects of the dietary composition as such without concomitant weight changes. However, change in body weight may be considered as a natural part of the outcome, as changing to a healthier diet may simultaneously decrease the energy intake and stimulate weight loss. Weight loss makes it harder to interpret the results, but it could be considered in statistical analyses. In some studies, positive effects on inflammatory markers have been seen without weight loss [24,29] or a decrease in CRP has remained significant after adjusting for the weight loss [28]. Another possible weakness in these studies is that LGI has not been a main primary outcome of many of these studies, but still were considered as primary outcomes. Thus, the studies might have been underpowered for LGI, and many participants had low levels of LGI already at the baseline. There are some variations in the characteristics of the participants among the studies e.g., in age, Body Mass Index (BMI), and health status (Table 1), which also may explain the variation in the results. Furthermore, the baseline diet and compliance to the HND might have been varied between the studies.

6. Concluding Remarks

This narrative review overviews and summarizes all the published papers covering the HND and LGI. Only 10 papers describing seven studies were found, including three observational studies and four interventions. The authors are not aware of other reviews investigating this issue in detail. Quite few studies have investigated the effect of HND on LGI so far. Two observational studies have shown an inverse association between the adherence to the HND and concentration of hsCRP. In the intervention studies, a significant decrease in the concentration of hsCRP has been reported in two studies [28,29] out of four studies measuring hsCRP [24,26,28,29]. Furthermore, the HND has had beneficial effects on concentrations of other inflammatory markers, such as IL-1Ra [24] and Cathepsin S [27], and it has been shown to downregulate the gene expression of inflammation related genes in adipose tissue and PBMC [20,30]. It is noteworthy that these positive effects have been seen without significant weight loss. These results suggest that the HND may have anti-inflammatory effects, but more carefully controlled studies are needed to confirm the anti-inflammatory effects of the HND.

Author Contributions

All authors were involved in the literature research, writing, reviewing, and editing of the manuscript.

Funding

This research was funded by the Academy of Finland (ML), grant number 309311.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Hotamisligil, G.S. Inflammation and Metabolic Disorders. Nature 2006, 444, 860–867. [Google Scholar] [CrossRef] [PubMed]
  2. Hansson, G.K. Inflammation, Atherosclerosis, and Coronary Artery Disease. N. Engl. J. Med. 2005, 352, 1685–1695. [Google Scholar] [CrossRef] [PubMed]
  3. Kern, L.; Mittenbuhler, M.J.; Vesting, A.J.; Ostermann, A.L.; Wunderlich, C.M.; Wunderlich, F.T. Obesity-Induced TNFalpha and IL-6 Signaling: The Missing Link between Obesity and Inflammation-Driven Liver and Colorectal Cancers. Cancers 2018, 11, 24. [Google Scholar] [CrossRef] [PubMed]
  4. Costantini, E.; D’Angelo, C.; Reale, M. The Role of Immunosenescence in Neurodegenerative Diseases. Mediat. Inflamm. 2018, 2018, 6039171. [Google Scholar] [CrossRef] [PubMed]
  5. Yudkin, J.S. Adipose Tissue, Insulin Action and Vascular Disease: Inflammatory Signals. Int. J. Obes. Relat. Metab. Disord. 2003, 27 (Suppl. 3), S25–S28. [Google Scholar] [CrossRef]
  6. Unamuno, X.; Gomez-Ambrosi, J.; Rodriguez, A.; Becerril, S.; Fruhbeck, G.; Catalan, V. Adipokine Dysregulation and Adipose Tissue Inflammation in Human Obesity. Eur. J. Clin. Investig. 2018, 48, e12997. [Google Scholar] [CrossRef]
  7. Chmelar, J.; Chung, K.J.; Chavakis, T. The Role of Innate Immune Cells in Obese Adipose Tissue Inflammation and Development of Insulin Resistance. Thromb. Haemost. 2013, 109, 399–406. [Google Scholar]
  8. de Mello, V.D.; Kolehmainen, M.; Pulkkinen, L.; Schwab, U.; Mager, U.; Laaksonen, D.E.; Niskanen, L.; Gylling, H.; Atalay, M.; Rauramaa, R.; et al. Downregulation of Genes Involved in NFkappaB Activation in Peripheral Blood Mononuclear Cells After Weight Loss is Associated with the Improvement of Insulin Sensitivity in Individuals with the Metabolic Syndrome: The GENOBIN Study. Diabetologia 2008, 51, 2060–2067. [Google Scholar] [CrossRef]
  9. Ferreira, C.M.; Vieira, A.T.; Vinolo, M.A.; Oliveira, F.A.; Curi, R.; Martins Fdos, S. The Central Role of the Gut Microbiota in Chronic Inflammatory Diseases. J. Immunol. Res. 2014, 2014, 689492. [Google Scholar] [CrossRef]
  10. Telle-Hansen, V.H.; Holven, K.B.; Ulven, S.M. Impact of a Healthy Dietary Pattern on Gut Microbiota and Systemic Inflammation in Humans. Nutrients 2018, 10, 1786. [Google Scholar] [CrossRef]
  11. Minihane, A.M.; Vinoy, S.; Russell, W.R.; Baka, A.; Roche, H.M.; Tuohy, K.M.; Teeling, J.L.; Blaak, E.E.; Fenech, M.; Vauzour, D.; et al. Low-Grade Inflammation, Diet Composition and Health: Current Research Evidence and its Translation. Br. J. Nutr. 2015, 114, 999–1012. [Google Scholar] [CrossRef] [PubMed]
  12. Calder, P.C.; Ahluwalia, N.; Brouns, F.; Buetler, T.; Clement, K.; Cunningham, K.; Esposito, K.; Jonsson, L.S.; Kolb, H.; Lansink, M.; et al. Dietary Factors and Low-Grade Inflammation in Relation to Overweight and Obesity. Br. J. Nutr. 2011, 106 (Suppl. 3), S5–S78. [Google Scholar] [CrossRef]
  13. Madsen, E.L.; Rissanen, A.; Bruun, J.M.; Skogstrand, K.; Tonstad, S.; Hougaard, D.M.; Richelsen, B. Weight Loss Larger than 10% is Needed for General Improvement of Levels of Circulating Adiponectin and Markers of Inflammation in Obese Subjects: A 3-Year Weight Loss Study. Eur. J. Endocrinol. 2008, 158, 179–187. [Google Scholar] [CrossRef] [PubMed]
  14. Ziccardi, P.; Nappo, F.; Giugliano, G.; Esposito, K.; Marfella, R.; Cioffi, M.; D’Andrea, F.; Molinari, A.M.; Giugliano, D. Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year. Circulation 2002, 105, 804–809. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  15. Esposito, K.; Pontillo, A.; Di Palo, C.; Giugliano, G.; Masella, M.; Marfella, R.; Giugliano, D. Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial. JAMA 2003, 289, 1799–1804. [Google Scholar] [CrossRef] [PubMed]
  16. Neale, E.P.; Batterham, M.J.; Tapsell, L.C. Consumption of a Healthy Dietary Pattern Results in Significant Reductions in C-Reactive Protein Levels in Adults: A Meta-Analysis. Nutr. Res. 2016, 36, 391–401. [Google Scholar] [CrossRef]
  17. Schwingshackl, L.; Hoffmann, G. Mediterranean Dietary Pattern, Inflammation and Endothelial Function: A Systematic Review and Meta-Analysis of Intervention Trials. Nutr. Metab. Cardiovasc. Dis. 2014, 24, 929–939. [Google Scholar] [CrossRef]
  18. Uusitupa, M.; Schwab, U. Diet, Inflammation and Prediabetes-Impact of Quality of Diet. Can. J. Diabetes 2013, 37, 327–331. [Google Scholar] [CrossRef]
  19. Kaluza, J.; Harris, H.; Melhus, H.; Michaelsson, K.; Wolk, A. Questionnaire-Based Anti-Inflammatory Diet Index as a Predictor of Low-Grade Systemic Inflammation. Antioxid. Redox Signal. 2018, 28, 78–84. [Google Scholar] [CrossRef]
  20. Kolehmainen, M.; Ulven, S.M.; Paananen, J.; de Mello, V.; Schwab, U.; Carlberg, C.; Myhrstad, M.; Pihlajamaki, J.; Dungner, E.; Sjolin, E.; et al. Healthy Nordic Diet Downregulates the Expression of Genes Involved in Inflammation in Subcutaneous Adipose Tissue in Individuals with Features of the Metabolic Syndrome. Am. J. Clin. Nutr. 2015, 101, 228–239. [Google Scholar] [CrossRef]
  21. De Mello, V.D.; Kolehmanien, M.; Schwab, U.; Pulkkinen, L.; Uusitupa, M. Gene Expression of Peripheral Blood Mononuclear Cells as a Tool in Dietary Intervention Studies: What do we Know so Far? Mol. Nutr. Food Res. 2012, 56, 1160–1172. [Google Scholar] [CrossRef] [PubMed]
  22. Kanerva, N.; Kaartinen, N.E.; Rissanen, H.; Knekt, P.; Eriksson, J.G.; Saaksjarvi, K.; Sundvall, J.; Mannisto, S. Associations of the Baltic Sea Diet with Cardiometabolic Risk Factors—A Meta-Analysis of Three Finnish Studies. Br. J. Nutr. 2014, 112, 616–626. [Google Scholar] [CrossRef]
  23. Kanerva, N.; Loo, B.M.; Eriksson, J.G.; Leiviska, J.; Kaartinen, N.E.; Jula, A.; Mannisto, S. Associations of the Baltic Sea Diet with Obesity-Related Markers of Inflammation. Ann. Med. 2014, 46, 90–96. [Google Scholar] [CrossRef] [PubMed]
  24. Uusitupa, M.; Hermansen, K.; Savolainen, M.J.; Schwab, U.; Kolehmainen, M.; Brader, L.; Mortensen, L.S.; Cloetens, L.; Johansson-Persson, A.; Onning, G.; et al. Effects of an Isocaloric Healthy Nordic Diet on Insulin Sensitivity, Lipid Profile and Inflammation Markers in Metabolic Syndrome—A Randomized Study (SYSDIET). J. Intern. Med. 2013, 274, 52–66. [Google Scholar] [CrossRef] [PubMed]
  25. Fritzen, A.M.; Lundsgaard, A.M.; Jordy, A.B.; Poulsen, S.K.; Stender, S.; Pilegaard, H.; Astrup, A.; Larsen, T.M.; Wojtaszewski, J.F.; Richter, E.A.; et al. New Nordic Diet-Induced Weight Loss is Accompanied by Changes in Metabolism and AMPK Signaling in Adipose Tissue. J. Clin. Endocrinol. Metab. 2015, 100, 3509–3519. [Google Scholar] [CrossRef] [PubMed]
  26. Adamsson, V.; Reumark, A.; Fredriksson, I.B.; Hammarstrom, E.; Vessby, B.; Johansson, G.; Riserus, U. Effects of a Healthy Nordic Diet on Cardiovascular Risk Factors in Hypercholesterolaemic Subjects: A Randomized Controlled Trial (NORDIET). J. Intern. Med. 2011, 269, 150–159. [Google Scholar] [CrossRef] [PubMed]
  27. Jobs, E.; Adamsson, V.; Larsson, A.; Jobs, M.; Nerpin, E.; Ingelsson, E.; Arnlov, J.; Riserus, U. Influence of a Prudent Diet on Circulating Cathepsin S in Humans. Nutr. J. 2014, 13, 84. [Google Scholar] [CrossRef] [PubMed]
  28. Poulsen, S.K.; Due, A.; Jordy, A.B.; Kiens, B.; Stark, K.D.; Stender, S.; Holst, C.; Astrup, A.; Larsen, T.M. Health Effect of the New Nordic Diet in Adults with Increased Waist Circumference: A 6-Mo Randomized Controlled Trial. Am. J. Clin. Nutr. 2014, 99, 35–45. [Google Scholar] [CrossRef] [PubMed]
  29. De Mello, V.D.; Schwab, U.; Kolehmainen, M.; Koenig, W.; Siloaho, M.; Poutanen, K.; Mykkanen, H.; Uusitupa, M. A Diet High in Fatty Fish, Bilberries and Wholegrain Products Improves Markers of Endothelial Function and Inflammation in Individuals with Impaired Glucose Metabolism in a Randomised Controlled Trial: The Sysdimet Study. Diabetologia 2011, 54, 2755–2767. [Google Scholar] [CrossRef]
  30. Myhrstad, M.C.W.; de Mello, V.D.; Dahlman, I.; Kolehmainen, M.; Paananen, J.; Rundblad, A.; Carlberg, C.; Olstad, O.K.; Pihlajamaki, J.; Holven, K.B.; et al. Healthy Nordic Diet Modulates the Expression of Genes Related to Mitochondrial Function and Immune Response in Peripheral Blood Mononuclear Cells from Subjects with Metabolic Syndrome-A SYSDIET Sub-Study. Mol. Nutr. Food Res. 2019, e1801405. [Google Scholar] [CrossRef]
  31. Joosten, M.M.; Witkamp, R.F.; Hendriks, H.F. Alterations in Total and High-Molecular-Weight Adiponectin After 3 Weeks of Moderate Alcohol Consumption in Premenopausal Women. Metabolism 2011, 60, 1058–1063. [Google Scholar] [CrossRef] [PubMed]
  32. Tian, Y.; Liimatainen, J.; Alanne, A.L.; Lindstedt, A.; Liu, P.; Sinkkonen, J.; Kallio, H.; Yang, B. Phenolic Compounds Extracted by Acidic Aqueous Ethanol from Berries and Leaves of Different Berry Plants. Food Chem. 2017, 220, 266–281. [Google Scholar] [CrossRef] [PubMed]
  33. Kolehmainen, M.; Mykkanen, O.; Kirjavainen, P.V.; Leppanen, T.; Moilanen, E.; Adriaens, M.; Laaksonen, D.E.; Hallikainen, M.; Puupponen-Pimia, R.; Pulkkinen, L.; et al. Bilberries Reduce Low-Grade Inflammation in Individuals with Features of Metabolic Syndrome. Mol. Nutr. Food Res. 2012, 56, 1501–1510. [Google Scholar] [CrossRef] [PubMed]
  34. Adamsson, V.; Reumark, A.; Marklund, M.; Larsson, A.; Riserus, U. Role of a Prudent Breakfast in Improving Cardiometabolic Risk Factors in Subjects with Hypercholesterolemia: A Randomized Controlled Trial. Clin. Nutr. 2015, 34, 20–26. [Google Scholar] [CrossRef] [PubMed]
  35. Mithril, C.; Dragsted, L.O.; Meyer, C.; Tetens, I.; Biltoft-Jensen, A.; Astrup, A. Dietary Composition and Nutrient Content of the New Nordic Diet. Public Health Nutr. 2013, 16, 777–785. [Google Scholar] [CrossRef] [PubMed]
  36. Poulsen, S.K.; Crone, C.; Astrup, A.; Larsen, T.M. Long-Term Adherence to the New Nordic Diet and the Effects on Body Weight, Anthropometry and Blood Pressure: A 12-Month Follow-Up Study. Eur. J. Nutr. 2015, 54, 67–76. [Google Scholar] [CrossRef]
  37. Gupta, S.; Singh, R.K.; Dastidar, S.; Ray, A. Cysteine Cathepsin S as an Immunomodulatory Target: Present and Future Trends. Expert Opin. Ther. Targets 2008, 12, 291–299. [Google Scholar] [CrossRef] [PubMed]
  38. Jobs, E.; Riserus, U.; Ingelsson, E.; Helmersson, J.; Nerpin, E.; Jobs, M.; Sundstrom, J.; Lind, L.; Larsson, A.; Basu, S.; et al. Serum Cathepsin S is Associated with Serum C-Reactive Protein and Interleukin-6 Independently of Obesity in Elderly Men. J. Clin. Endocrinol. Metab. 2010, 95, 4460–4464. [Google Scholar] [CrossRef]
  39. Marklund, M.; Magnusdottir, O.K.; Rosqvist, F.; Cloetens, L.; Landberg, R.; Kolehmainen, M.; Brader, L.; Hermansen, K.; Poutanen, K.S.; Herzig, K.H.; et al. A Dietary Biomarker Approach Captures Compliance and Cardiometabolic Effects of a Healthy Nordic Diet in Individuals with Metabolic Syndrome. J. Nutr. 2014, 144, 1642–1649. [Google Scholar] [CrossRef] [Green Version]
  40. Herder, C.; Brunner, E.J.; Rathmann, W.; Strassburger, K.; Tabak, A.G.; Schloot, N.C.; Witte, D.R. Elevated Levels of the Anti-Inflammatory Interleukin-1 Receptor Antagonist Precede the Onset of Type 2 Diabetes: The Whitehall II Study. Diabetes Care 2009, 32, 421–423. [Google Scholar] [CrossRef]
  41. Lankinen, M.; Schwab, U.; Kolehmainen, M.; Paananen, J.; Nygren, H.; Seppanen-Laakso, T.; Poutanen, K.; Hyotylainen, T.; Riserus, U.; Savolainen, M.J.; et al. A Healthy Nordic Diet Alters the Plasma Lipidomic Profile in Adults with Features of Metabolic Syndrome in a Multicenter Randomized Dietary Intervention. J. Nutr. 2016, 146, 662–672. [Google Scholar] [CrossRef] [PubMed]
  42. de Mello, V.D.; Paananen, J.; Lindstrom, J.; Lankinen, M.A.; Shi, L.; Kuusisto, J.; Pihlajamaki, J.; Auriola, S.; Lehtonen, M.; Rolandsson, O.; et al. Indolepropionic Acid and Novel Lipid Metabolites are Associated with a Lower Risk of Type 2 Diabetes in the Finnish Diabetes Prevention Study. Sci. Rep. 2017, 7, 46337. [Google Scholar] [CrossRef] [PubMed]
  43. Tuomainen, M.; Lindstrom, J.; Lehtonen, M.; Auriola, S.; Pihlajamaki, J.; Peltonen, M.; Tuomilehto, J.; Uusitupa, M.; de Mello, V.D.; Hanhineva, K. Associations of Serum Indolepropionic Acid, a Gut Microbiota Metabolite, with Type 2 Diabetes and Low-Grade Inflammation in High-Risk Individuals. Nutr. Diabetes 2018, 8, 35. [Google Scholar] [CrossRef] [PubMed]
  44. Papadaki, A.; Scott, J.A. The Impact on Eating Habits of Temporary Translocation from a Mediterranean to a Northern European Environment. Eur. J. Clin. Nutr. 2002, 56, 455–461. [Google Scholar] [CrossRef] [PubMed]
  45. Valsta, L.; Kaartinen, N.; Tapanainen, H.; Männistö, S.; Sääksjärvi, K. Nutrition in Finland—The National FinDiet 2017 Survey; Julkari: Helsinki, Finland, 2018; ISBN 978-952-343-238-3. [Google Scholar]
  46. Sakhaei, R.; Ramezani-Jolfaie, N.; Mohammadi, M.; Salehi-Abargouei, A. The Healthy Nordic Dietary Pattern has no Effect on Inflammatory Markers: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Nutrition 2019, 58, 140–148. [Google Scholar] [CrossRef] [PubMed]
  47. Mellberg, C.; Sandberg, S.; Ryberg, M.; Eriksson, M.; Brage, S.; Larsson, C.; Olsson, T.; Lindahl, B. Long-Term Effects of a Palaeolithic-Type Diet in Obese Postmenopausal Women: A 2-Year Randomized Trial. Eur. J. Clin. Nutr. 2014, 68, 350–357. [Google Scholar] [CrossRef] [PubMed]
  48. Blomquist, C.; Alvehus, M.; Buren, J.; Ryberg, M.; Larsson, C.; Lindahl, B.; Mellberg, C.; Soderstrom, I.; Chorell, E.; Olsson, T. Attenuated Low-Grade Inflammation Following Long-Term Dietary Intervention in Postmenopausal Women with Obesity. Obesity 2017, 25, 892–900. [Google Scholar] [CrossRef] [PubMed]
  49. Nordic Council of Ministers. Nordic Nutrition Recommendations 2012. In Integrating Nutrition and Physical Activity, Nord 2014:002 ed.; Nordic Council of Ministers: Copenhagen, Denmark, 2014. [Google Scholar]
Nutrients 11 01369 g001 550
Figure 1. Procedure for selection of articles.
Figure 1. Procedure for selection of articles.
Nutrients 11 01369 g001
Nutrients 11 01369 g002 550
Figure 2. Plasma concentrations (a) and relative changes (b) of high sensitivity C-reactive protein (hsCRP) according to study group in the participants not using statins during the SYSDIMET intervention [29]. (a) White bars represent hsCRP concentrations at baseline and black bars after a 12 week consumption of HND (n = 27), Whole Grain Enriched Diet (WGED) (n = 24) or control diet (n = 25).* p < 0.05 and ** p < 0.001 for baseline vs. week 12 in Student’s paired test. (b) p = 0.04 for the group effect in general linear model univariate analysis. * p < 0.05 for the difference between WGED and control groups after Bonferroni correction for multiple comparisons. Values are median and interquartile range (IQR).
Figure 2. Plasma concentrations (a) and relative changes (b) of high sensitivity C-reactive protein (hsCRP) according to study group in the participants not using statins during the SYSDIMET intervention [29]. (a) White bars represent hsCRP concentrations at baseline and black bars after a 12 week consumption of HND (n = 27), Whole Grain Enriched Diet (WGED) (n = 24) or control diet (n = 25).* p < 0.05 and ** p < 0.001 for baseline vs. week 12 in Student’s paired test. (b) p = 0.04 for the group effect in general linear model univariate analysis. * p < 0.05 for the difference between WGED and control groups after Bonferroni correction for multiple comparisons. Values are median and interquartile range (IQR).
Nutrients 11 01369 g002
Table
Table 1. Characteristic of studies investigating association or effect of the Healthy Nordic diet (HND) on low-grade inflammation (LGI).
Table 1. Characteristic of studies investigating association or effect of the Healthy Nordic diet (HND) on low-grade inflammation (LGI).
ReferencesYears of Data CollectionStudy DesignName of the StudyCountryPopulation
[22,23]2007Observational studyDILGOMFinlandn = 4579
A representative sample of the Finnish population in 5 large study areas
[22,23]2001–2004Observational studythe Helsinki Birth Cohort StudyFinlandn = 1911
Helsinki University Central Hospital area
[22]2000–2001Observational studyHealth 2000 SurveyFinlandn = 5180
A representative sample of the Finnish population from 80 health service districts
[20,24,30]2009–2010RCT
multicenter
18–24 weeks		SYSDIETDenmark
Finland
Iceland
Sweden		n = 166
men and women with features of MetS
mean age 55 years
mean BMI 31.6 kg/m2
[25,28]2010–2011RCT
26 weeks		New Nordic DietDenmarkn = 147
centrally obese men and women
mean age 42 years
mean BMI 30.2 kg/m2
[26,27]2007–2008RCT
6 weeks		NORDIETSwedenn = 86
mildly hypercholesterolaemic men and women
mean age 53 years
mean BMI 26.5 kg/m2
[29]2008–2009RCT
12 weeks		SYSDIMETFinlandn = 104
men and women with features of MetS
mean age 59 years
mean BMI 31.1 kg/m2
DILGOM, The Dietary, Lifestyle and Genetic Determinants of Obesity and Metabolic Syndrome study; MetS, Metabolic syndrome; RCT, Randomized controlled trial, BIM, Body Mass Index.
Table
Table 2. Observational studies investigating association between the Nordic diet and inflammatory markers (A) and intervention studies investigating effects of the Nordic Diet on inflammatory markers (B).
Table 2. Observational studies investigating association between the Nordic diet and inflammatory markers (A) and intervention studies investigating effects of the Nordic Diet on inflammatory markers (B).
ReferenceStudy NameDietary IntakeInflammatory Markers/Measurements Related to InflammationMain Results
(A)[23]DILGOM study (n = 4 579); Helsinki Birth Cohort Study (n = 1911)FFQ was used to measure dietary intake over the past year and to calculate the BSDS.leptin, HMW-adiponectin, TNF-alfa, IL-6, and hsCRP.An inverse association between the BSDS and hsCRP concentration in both studies (p < 0.01). No association with other inflammatory markers. In the DILGOM study HMW-adiponectin had inverse association with BSDS.
[22]DILGOM (n = 4776); Health 2000 Survey (n = 5180); Helsinki Birth Cohort Study (n = 1972)FFQ was used to measure dietary intake over the past year and to calculate the BSDS.hsCRPThe risk of elevated hsCRP concentration was lower among men (OR 0.58, p = 0.004) and women (OR 0.73, p = 0.001) in the highest BSDS quintile than among those in the lowest BSDS quintile.
ReferenceStudy NameStudy Groups (n) and Duration of the InterventionInflammatory Markers/Measurements Related to InflammationMain Results
(B)[24]SYSDIET
6 study centers in Nordic countries		(1) HND (n = 96)
(2) Control (average Nordic diet)
(n = 70) 18–24 weeks		IL-1Ra, IL-1β, IL10, TNF RII, hsCRPIL-1 Ra increased in the Control group. No differences between the groups in the other markers.
[20]SYSDIET
(3 centers out of 6)		(1) HND (n = 31)
(2) Control (n = 25) 18–24 weeks		Gene expression in subcutaneous adipose tissueGene expression of inflammation related genes was reduced in the HND group compared with the Control group.
[30]SYSDIET
(3 centers out of 6)		(1) HND (n = 42)
(2) Control (n = 26) 18–24 weeks		Gene expression in peripheral blood mononuclear cellsPathways and processes involved in the immune response were down-regulated in the HND group.
[28]New Nordic Diet(1) NND (n = 91)
(2) ADD (n = 56) 26 weeks		CRPCRP decreased in the NND group (p = 0.007). The decrease of CRP attenuated, but remained significant after adjusting for the weight loss (p = 0.043). The loss of body weight during the intervention was greater
(p < 0.001) in the NND group (~4.74 ± 0.48 kg) than in the ADD group (~1.52 ± 0.45 kg).
[25]Subset of New Nordic Diet(1) NND (n = 43)
(2) ADD (n = 21) 26 weeks		CRP, TNF-αNo significant changes in the whole population, but in women CRP concentration decreased 40% in the NDD group (p < 0.01). The model was not adjusted by weight loss. The loss of body weight during the intervention was greater in NDD than ADD (p < 0.01).
[26,27]NORDIET(1) HND (n = 44)
(2) Control (n = 42) 6 weeks		CRP, Cathepsin SNo change in CRP. Level of Cathepsin S was decreased in the HND group compared with the Control group (p = 0.003). The difference remained significant after adjusting for baseline Cathepsin S level, but not after adjusting for change in weight or LDL cholesterol concentration.
[29]SYSDIMET(1) Healthy Diet rich in whole grain, fatty fish and bilberries
(2) Whole Grain Enriched Diet (WGED)
(3) Control Diet 12 weeks		hsCRP, TNF-α, IL-6, IL1Ra, SAA, CCL5, sICAM-1 and MIFPlasma hsCRP concentration decreased in the WGED and Healthy Diet groups (p < 0.01 and p < 0.05, respectively) and the change in hsCRP in the WGED group was significantly different from that in the control group (p < 0.05). No changes in other inflammatory markers.
ADD, average Danish diet; BSDS, Baltic See Dietary Score; CCL5, chemokine (C-C motif) ligand 5; CRP, C-reactive protein; FFQ, food frequency questionnaire; HND, Healthy Nordic Diet; HMW-adiponectin, high molecular weight adiponectin; hsCRP, high sensitivity C-reactive protein; IL, interleukin; IL1Ra, Interleukin 1 receptor antagonist; MIF, macrophage migration inhibitory factor; NND, new Nordic Diet, SAA, serum amyloid A; sICAM-1, soluble intercellular cellular adhesion molecule-1; TNF-α, tumor necrosis factor alfa; TNF RII, tumor necrosis factor receptor II, WGED, Whole Grain Enriched Diet.

Share and Cite

MDPI and ACS Style

Lankinen, M.; Uusitupa, M.; Schwab, U. Nordic Diet and Inflammation—A Review of Observational and Intervention Studies. Nutrients 2019, 11, 1369. https://doi.org/10.3390/nu11061369

AMA Style

Lankinen M, Uusitupa M, Schwab U. Nordic Diet and Inflammation—A Review of Observational and Intervention Studies. Nutrients. 2019; 11(6):1369. https://doi.org/10.3390/nu11061369

Chicago/Turabian Style

Lankinen, Maria, Matti Uusitupa, and Ursula Schwab. 2019. "Nordic Diet and Inflammation—A Review of Observational and Intervention Studies" Nutrients 11, no. 6: 1369. https://doi.org/10.3390/nu11061369

APA Style

Lankinen, M., Uusitupa, M., & Schwab, U. (2019). Nordic Diet and Inflammation—A Review of Observational and Intervention Studies. Nutrients, 11(6), 1369. https://doi.org/10.3390/nu11061369

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop