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Adzuki Bean MY59 Extract Reduces Insulin Resistance and Hepatic Steatosis in High-Fat-Fed Mice via the Downregulation of Lipocalin-2

Nutrients 2022, 14(23), 5049; https://doi.org/10.3390/nu14235049

by Jaewoong Lee^1,†, Byong Won Lee^2,†, Kyung Eun Kim¹, Hyeong Seok An¹, Eun Ae Jeong¹, Hyun Joo Shin¹, Seok Bo Song² and Gu Seob Roh^1,*

Reviewer 1:

Shi Yang

Reviewer 2:

Johannes Mayr

Nutrients 2022, 14(23), 5049; https://doi.org/10.3390/nu14235049

Submission received: 11 November 2022 / Revised: 25 November 2022 / Accepted: 25 November 2022 / Published: 27 November 2022

(This article belongs to the Section Nutrition and Metabolism)

Round 1

Reviewer 1 Report

I am pleased to read this research results indicate that ABE feed- 24 ing could improve insulin resistance and hepatic steatosis by decreasing LCN2-mediated inflam- 25 mation and oxidative stress in HFD-fed mice, and Adzuki bean has this function.

Adzuki bean can preventing lipid accumulation and adipocytokine 286 production and improving glucose tolerance. it's very important.

I suggestion to add a picture of Adzuki bean in the paper, so that common people reading this paper can know exactly which plant it is.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

Thank you for the privilege of reviewing the manuscript on Adzuki bean extraxt effects on insulin resistance and hepatic steatosis in high-fat fed mice.

The article is very interesting and the study is performed correctly.

Please insert a paragraph on "limitations of study" at the end of discussion section.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

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Adzuki Bean MY59 Extract Reduces Insulin Resistance and Hepatic Steatosis in High-Fat-Fed Mice via the Downregulation of Lipocalin-2

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