Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624
APL Molecular Variants | Translocations | ATRA Sensitivity | ATO Sensitivity | No. of Cases Reported | Gene Other Than PML, Breakpoint | Gene Other Than PML, Splice Site | Genomic Insertions | RARA, Breakpoint | RARA, Splice Site | Reference |
---|---|---|---|---|---|---|---|---|---|---|
ZBTB16 (PLZF)-RARA | t(11;17)(q23;q21) | Poorly responsive | Poorly responsive | >30 [85] | Intron 3 | CAGgtaggc | Intron 2 | ctctagCCA | [102] | |
Intron 4 | CTGgtgagt | Intron 2 | ctctagCCA | [102] | ||||||
NPM1-RARA | t(5;17)(q35;q21) | Sensitive | ND | 5 [103] | Intron 5 | CAGgtagag | Intron 2 | ctctagCCA | [103] | |
Intron 5 | CAGgtagag | 79 nt with no homology to sequences in the GenBank or EMBL databases | Intron 2 | ctctagCCA | [104] | |||||
Intron 4 | TAGgtatgt | Intron 2 | ctctagCCA | [103] | ||||||
NUMA1 (NUMA)-RARA | t(11;17)(q13;q21) | Sensitive | ND | 1 | Intron 23 | CAGgtgagg | Intron 2 | ctctagCCA | [89] | |
STAT5B-RARA | der(17) | Poorly responsive | Poorly responsive | 11 [105] | Intron 15 | CTCgtgagt | Intron 2 | ctctagCCA | [90,105] | |
PRKAR1A-RARA | t(17;17)(q21;q24) or del(17)(q21;q24) | Sensitive | Sensitive | 1 | Intron 2 | AAGgtaaaa | Intron 2 | ctctagCCA | [91] | |
FIP1L1-RARA | t(4;17)(q12;q21) | Sensitive in 1 case | ND | 2 | Intron 15 | ATGgtaagt | Intron 2 | ctctagCCA | [92] | |
Intron 13 | CGGgtaaat | Intron 2 | ctctagCCA | [106] | ||||||
BCOR-RARA | t(X;17)(p11;q21) | Sensitive in 2 cases | Insensitive in 1 case | 2 | Intron 12 | CAGgtatga | Intron 2 | ctctagCCA | [93] | |
Exon 12 | CAGgtagaa | Intron 2 | ctctagCCA | [107] | ||||||
NABP1 (OBFC2A)-RARA | t(2;17)(q32;q21) | Sensitive in vitro | ND | 1 | Intron 5 | TGGgtaaga | Intron 2 | ctctagCCA | [94] | |
TBL1XR1 (TBLR1)-RARA | t(3;17)(q26;q21) | Insensitive | ND | 4 [108] | Intron 5 | CAAgtgagc | Intron 2 | ctctagCCA | [95] | |
Intron 5 | CAAgtgagc | * | Intron 2 | ctctagCCA | [108] | |||||
GTF2I-RARA | t(7;17)(q11;q21) | Sensitive | Sensitive | 1 | Intron 6 | TAGgtaagt | Intron 2 | ctctagCCA | [96] | |
IRF2BP2-RARA | t(1;17)(q42;q21) | Sensitive | Sensitive | 5 [109] | Exon 2 | TGTcccctg | Intron 2 | ctctagCCA | [97,109] | |
Exon 1 | AAGgtgcgg | Intron 2 | ctctagCCA | [110] | ||||||
Intron 1 | CAGgtaggg | Intron 2 | ctctagCCA | [111] | ||||||
Exon 1 | CAGgcaggt | Intron 2 | ctctagCCA | [111,112] | ||||||
FNDC3B-RARA | t(3;17)(q26;q21) | Sensitive | ND | 1 | Intron 24 | AAGgtgtgt | Intron 2 | ctctagCCA | [98] |
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Reference
- Liquori, A.; Ibañez, M.; Sargas, C.; Sanz, M.Á.; Barragán, E.; Cervera, J. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. [Google Scholar] [CrossRef] [PubMed] [Green Version]
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Liquori, A.; Ibañez, M.; Sargas, C.; Sanz, M.Á.; Barragán, E.; Cervera, J. Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. Cancers 2021, 13, 3440. https://doi.org/10.3390/cancers13143440
Liquori A, Ibañez M, Sargas C, Sanz MÁ, Barragán E, Cervera J. Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. Cancers. 2021; 13(14):3440. https://doi.org/10.3390/cancers13143440
Chicago/Turabian StyleLiquori, Alessandro, Mariam Ibañez, Claudia Sargas, Miguel Ángel Sanz, Eva Barragán, and José Cervera. 2021. "Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624" Cancers 13, no. 14: 3440. https://doi.org/10.3390/cancers13143440
APA StyleLiquori, A., Ibañez, M., Sargas, C., Sanz, M. Á., Barragán, E., & Cervera, J. (2021). Correction: Liquori et al. Acute Promyelocytic Leukemia: A Constellation of Molecular Events around a Single PML-RARA Fusion Gene. Cancers 2020, 12, 624. Cancers, 13(14), 3440. https://doi.org/10.3390/cancers13143440