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Background:
Review

Therapeutic Strategies for Patients with Advanced Small Bowel Adenocarcinoma: Current Knowledge and Perspectives

by
Emilie Moati
1,
Michael J. Overman
2 and
Aziz Zaanan
1,3,*
1
Department of Gastroenterology and Digestive Oncology, Institut du Cancer Paris Carpem, Assistance Publique des Hôpitaux de Paris, European Georges Pompidou Hospital, University of Paris, 75015 Paris, France
2
Department of Gastrointestinal Medical Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA
3
Centre de Recherche des Cordeliers, INSERM UMRS1138, CNRS, Sorbonne Université, USPC, Université de Paris, Equipe Labellisée Ligue Nationale Contre le Cancer, CNRS SNC 5096, 75006 Paris, France
*
Author to whom correspondence should be addressed.
Cancers 2022, 14(5), 1137; https://doi.org/10.3390/cancers14051137
Submission received: 18 January 2022 / Revised: 21 February 2022 / Accepted: 22 February 2022 / Published: 23 February 2022
(This article belongs to the Special Issue Small Bowel Adenocarcinoma)
Review Reports Versions Notes

Abstract

:

Simple Summary

Small bowel adenocarcinomas (SBA) are rare tumors with a poor prognosis. Due to the rareness of this illness, there is limited scientific data to guide therapeutic management. The recent large prospective ARCAD-NADEGE study evaluated 347 patients with SBA and has helped to improve our current knowledge of this disease. When diagnosed with advanced, non-surgically resectable disease, chemotherapy remains the cornerstone of the treatment and appears to add a survival benefit compared to palliative care. Other more recent drugs, such as small molecule targeted therapeutic inhibitors or immunotherapy, may have a role in improving the outcome of patients with advanced SBA. In this review, we summarized the classical therapeutic arsenal as well as possible future promising treatments in advanced SBA.

Abstract

Small bowel adenocarcinoma (SBA) is diagnosed at an advanced (unresectable or metastatic) tumor stage in approximately one-third of cases. This is partly due to the non-specific symptomatology and limitations in endoscopic and radiologic detection methods. In this context, the prognosis remains poor and systemic chemotherapy appears to benefit patients when compared to best supportive care alone, despite the absence of randomized controlled trials. The results of a recent large prospective cohort (ARCAD-NADEGE) reported that the absence of chemotherapy was a predictive factor for a lower overall survival (OS) even though poor differentiation and SBA associated with Crohn’s disease correlate with poor prognosis. In retrospective series, the median OS ranges from approximately 9 to 18 months with current treatment approaches. A combination of a fluoropyrimidine and oxaliplatin (FOLFOX or CAPOX) appears to be the most utilized and effective first-line chemotherapy regimen. Other front-line alternatives are the combination of 5-FU and cisplatin or fluoropyrimidine and irinotecan (FOLFIRI). In second-line, FOLFIRI is an effective option after progression on platinum-based therapy. Taxane-based therapy appears to be an alternative option, but further evaluation in larger series is needed. To a limited extent, the role of surgical resection for metastatic disease appears to be a valid option, though this approach has not been evaluated in prospective clinical studies. Due to the rareness of the disease, inclusion in clinical trials should be prioritized, and there is hope that targeted therapies and immunotherapy may enter the therapeutic arsenal for these patients.

1. Introduction

Small bowel adenocarcinoma (SBA), duodenal, jejunal, or ileum localizations, is a rare disease and accounts for 3–5% of gastrointestinal cancers. These tumors are diagnosed at an advanced (unresectable or metastatic) stage in around one-third of cases, in part due to the non-specific nature of clinical symptoms. With the development of improved imaging techniques and advances in endoscopy, such as enteroscopy and capsule endoscopy, it is possible that trends toward earlier diagnosis can be seen in the future [1,2,3]. In the NADEGE cohort study, the tumor stage at diagnosis was localized or resectable in 54%, locally advanced, unresectable in 5.5%, metastatic in 33.5%, and undetermined clinical stage in 7% [4]. As in many other cancers, the most important prognostic factor in SBA is the TNM classification. Despite a relative improvement in the median overall survival (OS) for localized disease, the overall prognosis for SBA remains poor. The 5-year overall survival (OS) rate is 50% for stage I, 40% for stage II, 10–40% for stage III, and reaching less than 5% for stage IV disease [5]. The other factors associated with a worse prognosis are male gender, duodenal location, poor differentiation, and SBA associated with Crohn’s disease as compared to de novo SBA [5,6,7,8]. Retrospective studies demonstrated the ability to resect limited metastatic disease, but no prospective studies were conducted. For unresectable metastatic disease, resection of the primary tumor should only be considered in the case of primary tumor symptomatology, such as perforation, bowel obstruction, or uncontrolled gastrointestinal bleeding. For all other situations, the main modality of therapy for metastatic SBA is palliative chemotherapy. This review focuses upon the role of systemic therapy, surgical metastasectomy, and the novel therapies such as targeted therapies and immunotherapy in advanced SBA.

2. Systemic Chemotherapy

Although no randomized clinical trials have yet reported a benefit for systemic chemotherapy compared to best supportive care alone, retrospective studies suggested a benefit for palliative chemotherapy. One of the earliest retrospective studies reported overall survival (OS) of 12 versus 2 months for systemic chemotherapy and best supportive care, respectively [6]. Several retrospective or prospective studies since reported a survival benefit for the administration of chemotherapy compared to best supportive care alone, with a median OS ranging from 9 to 19 months in patients with palliative chemotherapy, whereas it ranged only from 2 to 13 months in patients with palliative care [4,6,9,10,11,12,13,14] (Table 1).
The results of a recent large prospective cohort (NADEGE) reported that the only predictive factor of a lower OS was the absence of chemotherapy. These data are, however, subjected to bias as patients who did not receive chemotherapy were more likely to be frail and have a poorer performance status [4]. In this observational study, a benefit of palliative chemotherapy was described with a median OS of 14.3 months for the 86 patients receiving systemic chemotherapy versus 2.2 months for 15 patients treated with palliative care only. Among all patients with metastatic disease, the median OS was 12.7 months [4]. Furthermore, although having a prognostic impact, the tumor location had no impact on the response to chemotherapy.
These survival results are consistent with those reported in several phase II studies with an OS ranging from 8 to 20 months and a PFS ranging from 3 to 11 months for patients treated with various chemotherapy regimens [15,16,17,18,19,20] (Table 2).

2.1. First-Line Chemotherapy Regimen

In most studies: first-line chemotherapy was mainly 5-FU based regimens, with or without a platinum salt or irinotecan. These different regimens are shown in Table 1 and Table 2 [15,16,17,18,20,21,22,23,24,26,27,28].
In the NADEGE cohort, chemotherapy was given to 122 metastatic SBA patients with regimes being FOLFOX or capecitabine and oxaliplatin (CAPOX) in 69.8% of patients, FOLFIRI in 18.6% of patients, and 5-FU monotherapy in 7.0% of patients [4]. In summary, a fluoropyrimidine and oxaliplatin (FOLFOX or CAPOX) appear to be the most used and effective first-line chemotherapy.
One of the first studies of chemotherapy in SBA involving eight advanced SBA patients reported a median OS of 13 months and a median PFS of 7.8 months for patients treated with 5-FU-based chemotherapy. A second early study of 20 patients reported a median OS of 14 months for patients treated with the combination of 5-FU and a platinum salt [21,22].
The benefit of 5-FU combined with a platinum salt in comparison to other chemotherapy regimens is suggested by one retrospective study involving 80 patients with advanced SBA. In this series, median PFS and OS were 8.7 and 14.8 months, respectively, for 5-FU and cisplatin, which was significantly better than other chemotherapy regimens [23].
In a retrospective Japanese single-center study involving 132 patients, Tsushima et al. reported that FOLFOX demonstrated improved PFS and a trend towards better OS when compared to other chemotherapy regimens [26]. The potential benefit for a fluoropyrimidine and a platinum agent over other chemotherapy is supported by a retrospective multicenter study reported by Zaanan et al. In this study involving 93 SBA patients, FOLFOX treated patients had an improved OS of 17.8 months in comparison to other chemotherapy regimens such as 5-FU alone or combined with cisplatin or irinotecan [24]. In the subgroup of patients treated with platinum-based chemotherapy, multivariate analysis demonstrated that the FOLFOX regimen in comparison to the combination of 5-FU and cisplatin was associated with an improved median PFS, 6.9 versus 4.8 months (p < 0.0001), and an improved median OS, 17.8 versus 9.3 months (p = 0.02), respectively. For all first-line regimens, the median OS was 15.1 months [24].
These results are similar to those from three prospective phase II trials, in which encouraging objective response rate (ORR) and OS were reported for the combination of a fluoropyrimidine and oxaliplatin (FOLFOX or CAPOX) in the front-line setting. In these three trials, ORR ranged from 45 to 50%, and median OS ranged from 15.2 to 20.4 months [16,17,18] (Table 2). In these studies, toxicities were generally mild, with the most common grade III or IV treatment-related toxicities being hematological (neutropenia or thrombocytopenia) in 10% to 63%, fatigue in 3% to 30%, diarrhea in 3% to 10%, nausea or vomiting in 3% to 10%, and peripheral neuropathy in 9% to 25% of the patients.
The association of 5-FU, mitomycin, and doxorubicin was evaluated in one phase II multicenter study involving 39 patients with SBA or adenocarcinoma of the ampulla of Vater. This combination demonstrated disappointing results with an ORR of 18.4% and a median OS of 8 months [15]. As expected, the most frequent toxicities were hematological and gastrointestinal, with grade III to V toxicities reported in 26 (72%) of the 36 patients evaluated and with one patient dying from grade V hematological toxicity [15].
Another first-line option is triplet chemotherapy consisting of 5-FU, oxaliplatin, and irinotecan (CAPIRINOX or FOLFIRINOX) as it is utilized for metastatic colorectal or pancreatic cancer. However, in a recent phase II study involving 33 patients, McWilliams et al. reported a median OS of 13.4 months and a disease control rate of 37.5% in patients with advanced SBA with the first-line use of CAPIRINOX [20]. Although not formally compared, the response rate and survival for CAPIRINOX are lower than those described in the phase II trials with CAPOX or FOLFOX [16,17,18,20] (Table 2).

2.2. Second-Line Chemotherapy Regimen

Few data exist for second-line chemotherapy (Table 2). In the small series by Locher et al., second-line FOLFIRI demonstrated a median PFS of 5 months in eight patients. Among these eight patients, five had a clinical benefit [22]. These results are supported by a multicenter retrospective series reported by Zaanan et al., in which 28 patients treated with FOLFIRI demonstrated an ORR and disease control rate of 20% and 50%, respectively. In the same study, median PFS and OS were 3.5 months and 10.5 months, respectively [25]. In this series, 48% of the patients had grade III or IV therapy-related adverse events, mainly neutropenia in 37% and gastrointestinal in 14%. One treatment-related death due to grade V neutropenia was reported [25]. These data suggest a modest activity and a relatively manageable toxicity profile for FOLFIRI as a second-line treatment in patients with progressive advanced SBA after platinum-based first-line chemotherapy.
Two other small studies suggested clinical activity for taxane-based therapy in advanced SBA after first-line chemotherapy [19,28]. In a retrospective study, Aldrich et al. reported the results from taxane-based therapy in 20 patients demonstrating an ORR of 65% and a median PFS and OS of 3.8 and 10.7 months, respectively [28]. A prospective phase II study reported by Overman et al. reported similar results for 10 evaluable patients with advanced SBA treated with nab-paclitaxel with median PFS and OS of 3.2 and 10.9 months, respectively [19]. Although the sample sizes are small, taxane chemotherapy might represent a novel therapeutic option for SBA patients; however, replication in larger datasets is needed [19,28].
Limited data exist regarding other chemotherapy regimens in advanced SBA. Some responses with gemcitabine were described in several studies, suggesting a benefit from this drug [9,23]. In the retrospective series by Fishman et al., an ORR of 33.3% for gemcitabine alone and an ORR of 50% for the combination of a fluoropyrimidine and gemcitabine in first or second-line setting was reported [8]. Another study reported no responses in the first-line therapy with gemcitabine but one response among two patients treated by gemcitabine in the second-line setting [23]. More recently, a retrospective study reported by Aydin et al. demonstrated an ORR of 20%, a median PFS of 6 months, and a median OS of 11 months among 10 patients treated by gemcitabine monotherapy in the first-line setting [27]. These data appear to support the clinical activity of gemcitabine in advanced SBA.

3. Targeted Therapies

Due to some similarities between SBA and colorectal cancer (CRC) in terms of molecular alterations and effective chemotherapy regimens, targeted therapies usually used in CRC, such as anti-epidermal growth factor receptor (EGFR) or anti-vascular endothelial growth factor (VEGF), were studied in advanced SBA.

3.1. Anti-Angiogenic Therapies

The role of anti-angiogenic therapies, such as bevacizumab or ramucirumab, which were well established in metastatic CRC, underwent limited evaluation in advanced SBA, despite the known importance of the VEGF pathway in SBA [29]. Indeed, immunohistochemical expression of VEGF-A was recently reported as a potentially useful biomarker for the prediction of the efficacy of bevacizumab-based treatment in patients with advanced SBA [30].
Most studies evaluating bevacizumab in advanced SBA are retrospective and have suggested a survival benefit with the addition of bevacizumab to standard chemotherapy (Table 3) [31,32,33].
Only one phase II trial evaluated the combination of bevacizumab and CAPOX in metastatic SBA or ampullary adenocarcinoma. This study reported a 6 month PFS rate of 68% and an ORR of 48% [34]. However, despite the absence of statistical comparison, these results did not appear improved compared to similar results reported from an earlier conducted phase II trial of CAPOX [16].
An ongoing randomized phase II trial is currently evaluating ramucirumab and paclitaxel versus FOLFIRI in refractory SBA previously treated by a fluoropyrimidine and/or oxaliplatin. This trial may help define the therapeutic algorithm for second-line chemotherapy in advanced SBA (NCT 04205968) (Table 3).

3.2. Anti-EGFR

By analogy with CRC, studies have evaluated the benefit of anti-EGFR antibodies in RAS wild-type advanced SBA [35,36,37,38] (Table 3). Indeed, the proportion of RAS mutations in SBA is around 40% to 53%, initially suggesting a theoretical potential efficiency of anti-EGFR antibodies may apply to approximately one-half of all SBA [43,44].
An early case series of four patients suggested a benefit from cetuximab when combined with irinotecan in patients with advanced SBA. Among these four patients, one patient obtained a complete response, two patients had a partial response, and one patient had stable disease at the first evaluation. Among the three patients tested for KRAS mutations, all had a wild-type mutational status and corresponded to the two partial responses and the one complete response [35].
Another retrospective multicenter study involving 13 patients with metastatic SBA receiving anti-EGFR antibody (cetuximab or panitumumab) in monotherapy or in association with chemotherapy in first- or second-line treatment reported a median PFS of 5.5 months, a median OS of 15.8 months, and a complete response rate of 15%, a partial response rate of 39%, stable disease rate of 23%, and progression disease rate of 15%. However, in this work, RAS mutational status was not reported [36].
By focusing on KRAS wild-type metastatic SBA patients, another retrospective single-center study reported on 25 patients treated with either cetuximab (n = 19) or panitumumab (n = 6) as a single agent or in combination with chemotherapy. In this study, an ORR of 12%, a DCR of 36%, and a progressive disease rate of 64% were reported [37].
The results of a recent single-arm phase II study also reported disappointing results with no responses seen from panitumumab monotherapy in nine metastatic RAS wild-type SBA and ampullary adenocarcinoma patients [38].
Apart from RAS mutations, EGFR mutations were reported in approximately 2.5% of SBA [44], leading to an evaluation of EGFR tyrosine kinase inhibitors, such as erlotinib in advanced SBA. In a case report of a patient with concomitant lung and duodenal adenocarcinoma with an EGFR mutation, the treatment of erlotinib and S-1 resulted in a partial response [39] (Table 3).

3.3. Other Promising Targeted Therapies

The recently improved understanding of the mutational landscape of SBA may lead to specific targeted therapies, such as anti-HER2 antibodies, anti-MEK tyrosine kinase, PIK3CA inhibitors, or NTRK-directed therapies. The use of anti-HER2 antibodies was reported in one case report in which aHER2 amplified duodenal cancer demonstrated a response to trastuzumab and FOLFOX in the neoadjuvant setting [45].
Though NTRK inhibitors have not been evaluated in advanced SBA, they already demonstrated anti-tumoral activity in a variety of tumor types with NTRK fusions [46]. It might therefore be administrated in case of this molecular alteration in advanced SBA [47].

4. Immune Checkpoint Inhibitors

Immune checkpoint inhibitors (ICIs) appear today as the cornerstone of immunotherapy in several cancer types and are mainly represented by antibodies targeting anti-programmed cell death protein 1 (PD-1), anti-programmed cell death ligan-1 (PD-L1), and anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4). Predictive biomarkers of ICIs, such as PD-L1 expression, combined positive score (CPS), microsatellite instability (MSI), and tumor mutational burden (TMB), are currently used in several types of cancers [48,49,50,51,52]. Predictive biomarkers for the efficiency of ICI in SBA remain under evaluation.
The phase II basket trial, KEYNOTE-158, investigated pembrolizumab, an anti-PD-1 antibody, in advanced MSI solid tumors that experienced failure with prior therapy. For the subgroup of 19 patients with advanced SBA, the reported ORR was 42.1%, median PFS was 9.2 months, and median OS was unreached [40].
In the recent ZEBRA multicenter phase II study involving 40 patients with unresectable or metastatic SBA, pembrolizumab was evaluated as second-line treatment. In this study, 50% of the four patients with MSI-high tumors had a partial response, while 3% of the 32 MSS patients had a partial response. MSI status was unknown for four patients in this study [41].
Another single-agent, open-label, phase II study evaluating avelumab, an anti-PD-L1 antibody, in patients with advanced or metastatic SBA reported that avelumab was considered safe, and antitumor activity was observed as evidenced by a 29% RR and 71% DCR [42].
Combinations of ICIs together or ICIs combined with targeted therapies or chemotherapy are also being investigated. Two phase II studies are currently ongoing for the treatment of rare tumors, and both include SBA. The first trial combines ipilimumab (an anti-CTLA-4 antibody) with nivolumab (an anti-PD-1 antibody) compared to nivolumab monotherapy (NCT 02834013). The second trial compares cobimetinib (a mitogen-activated protein kinase (MEK) inhibitor) and atezolizumab (an anti-PD-L1 antibody) (NCT03108131). The results of targeted therapies of ICIs investigated in advanced SBA are summarized in Table 3.
A major challenge for SBA is the need to develop biomarkers to predict clinical benefits from ICIs. Apart from biomarkers such as MSI status, tumor mutational burden, and tumor-infiltrating lymphocytes, other potential biomarkers of interest should be explored. For example, the gut microbiome could have crosstalk with cancer immune response and immunotherapy [53]. Furthermore, ferroptosis, a form of regulated cell death mainly relying on iron-mediated oxidative damage and subsequent cell membrane damage, seems to affect the efficacy of cancer treatments, and thus combinations with agents targeting ferroptosis signaling may be of relevance to SBA [54]. However, there is currently no specific data evaluating the gut microbiome or ferroptosis with regard to tumor response in the treatment of SBA.

5. Specific Cases Management in Advanced SBA

5.1. Resection of Small Bowel Adenocarcinoma Metastases

There are limited data regarding the prognosis of patients with resected metastatic SBA. Therefore, outcomes of a sub-group of 34 patients with curatively resected metastatic SBA of the ARCAD-NADEGE study were analyzed. The metastatic sites were mainly peritoneal (29.4%), liver (26.5%), lymph nodes (11.8%), lung (2.9%), multiple (14.7%), or other (14.7%) [55]. The median OS for these patients undergoing curative-intent metastatic resection of SBA was 28.6 months, which is better than the median OS of 12.7 months for all metastatic patients in the NADEGE cohort. Although there are major limitations to cross-trial comparisons, this OS compares favorably to those recently reported in studies of patients treated with palliative chemotherapies [15,16,17,18,19,20]. However, patients with resected metastasis in the ARCAD-NADEGE cohort were highly selected patients with 85% (n = 29) of patients with a solitary metastatic site and therefore not representative of all metastatic SBA patients. Among all metastatic SBA resected patients, 30 (88.2%) also received perioperative chemotherapy, though perioperative chemotherapy was not associated with a better OS in this subgroup of patients [55]. Negative predictive factors for OS after metastasectomy were poor differentiation, positive margins, and lymphatic invasion.

5.2. Peritoneal Carcinomatosis

Peritoneal carcinomatosis is a frequent site of disease ranging from around 25 to 50% of metastatic SBA [6,55,56]. Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) was evaluated for SBA patients with peritoneal carcinomatosis. In eight observational studies, survival outcomes and toxicities were evaluated [57,58,59,60,61,62,63] (Table 4). In these studies, median OS from CRS + HIPEC ranges from 16 to 47 months, and grade III or IV treatment-related toxicities range from 12 to 35% (Table 4). The main observed complications are post-operative infections, abdominal collections, hematological toxicity, re-interventions, and pleural effusions.
In the largest multicenter study by Liu et al. with 152 patients receiving CRS + HIPEC between 1989 and 2016, the median OS was 32 months with a median disease-free survival of 14 months. In the multivariate analysis, a Peritoneal Cancer Index (PCI) ≤ 15 was independently associated with an improvement in OS (p = 0.003) [62]. However, despite a tolerable rate of grade III or IV treatment-related toxicities (19.1%) there was a 2% death rate due to multiorgan failure.
Thus, in SBA patients with limited peritoneal carcinomatosis (PCI ≤ 15) and a physical status allowing for a major surgical procedure, CRS and HIPEC could be considered in expert centers [57,59,60,61,62,64,65].

6. Conclusions

Systemic chemotherapy appears to be benefit patients with advanced SBA compared to best supportive care alone, though data from randomized controlled trials are lacking.
The combination of a fluoropyrimidine and oxaliplatin (FOLFOX or CAPOX) remains the most used and effective first-line chemotherapy with manageable toxicities. Alternatives in the first-line are 5-FU and cisplatin or FOLFIRI. In the second-line setting, FOLFIRI appears to be an effective option. Taxane-based therapy also appears to be clinically active, but further evaluation in larger series is needed.
The benefit of targeted therapies for SBA is uncertain and continues to be investigated. Immune checkpoint inhibitors have demonstrated robust activity for the subset of SBA with MSI. Due to the rareness of the disease, inclusion in clinical trials should be prioritized when feasible.
For selected patients, surgical resection of metastatic disease can be considered, especially in cases of isolated peritoneal, liver, or lung metastasis. For the specific location of peritoneal carcinomatosis, SBA patients with limited peritoneal disease should be considered for HIPEC and CRS at centers of excellence.

Author Contributions

Conceptualization, E.M. and A.Z.; methodology, A.Z.; software, E.M.; validation, E.M. and A.Z.; formal analysis, A.Z.; investigation, E.M.; resources, E.M.; data curation, E.M.; writing—original draft preparation, M.J.O. and E.M.; writing—review and editing, E.M.; visualization, A.Z.; supervision, A.Z.; project administration, A.Z. All authors have read and agreed to the published version of the manuscript.

Funding

This study received no external funding.

Conflicts of Interest

E.M. declares a consulting and/or advisory boards for Servier. A.Z. declares a consulting and/or advisory boards for Amgen, Lilly, Merck, Roche, Sanofi, Servier, Baxter, MSD, Pierre Fabre, Havas Life, Alira Health, Zymeworks. M.J.O. declares consulting and/or advisory boards for Takeda Pharmaceuticals, Ipsen Biopharmaceuticals, Pfizer, Merck, Glaxosmithkline, Nouscom, Gritstone, 3D Medicine, Phanes Therapeutics. The other authors declare no conflict of interest.

References

  1. Raghav, K.; Overman, M.J. Small Bowel Adenocarcinomas—Existing Evidence and Evolving Paradigms. Nat. Rev. Clin. Oncol. 2013, 10, 534–544. [Google Scholar] [CrossRef] [PubMed]
  2. Legué, L.M.; Bernards, N.; Gerritse, S.L.; van Oudheusden, T.R.; de Hingh, I.H.J.T.; Creemers, G.-J.M.; Ten Tije, A.J.; Lemmens, V.E.P.P. Trends in Incidence, Treatment and Survival of Small Bowel Adenocarcinomas between 1999 and 2013: A Population-Based Study in The Netherlands. Acta Oncol. 2016, 55, 1183–1189. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  3. Siegel, R.L.; Miller, K.D.; Jemal, A. Cancer Statistics, 2015. CA Cancer J. Clin. 2015, 65, 5–29. [Google Scholar] [CrossRef] [PubMed]
  4. Aparicio, T.; Henriques, J.; Manfredi, S.; Tougeron, D.; Bouché, O.; Pezet, D.; Piessen, G.; Coriat, R.; Zaanan, A.; Legoux, J.-L.; et al. Small Bowel Adenocarcinoma: Results from a Nationwide Prospective ARCAD-NADEGE Cohort Study of 347 Patients. Int. J. Cancer 2020, 147, 167–177. [Google Scholar] [CrossRef]
  5. Howe, J.R.; Karnell, L.H.; Menck, H.R.; Scott-Conner, C. The American College of Surgeons Commission on Cancer and the American Cancer Society. Adenocarcinoma of the Small Bowel: Review of the National Cancer Data Base, 1985–1995. Cancer 1999, 86, 2693–2706. [Google Scholar] [CrossRef]
  6. Dabaja, B.S.; Suki, D.; Pro, B.; Bonnen, M.; Ajani, J. Adenocarcinoma of the Small Bowel: Presentation, Prognostic Factors, and Outcome of 217 Patients. Cancer 2004, 101, 518–526. [Google Scholar] [CrossRef]
  7. Talamonti, M.S.; Goetz, L.H.; Rao, S.; Joehl, R.J. Primary Cancers of the Small Bowel: Analysis of Prognostic Factors and Results of Surgical Management. Arch. Surg. 2002, 137, 564–570, discussion 570–571. [Google Scholar] [CrossRef] [Green Version]
  8. Chin, Y.H.; Jain, S.R.; Lee, M.H.; Ng, C.H.; Lin, S.Y.; Mai, A.S.; Muthiah, M.D.; Foo, F.J.; Sundar, R.; Ong, D.E.H.; et al. Small Bowel Adenocarcinoma in Crohn’s Disease: A Systematic Review and Meta-Analysis of the Prevalence, Manifestation, Histopathology, and Outcomes. Int. J. Colorectal Dis. 2022, 37, 239–250. [Google Scholar] [CrossRef]
  9. Fishman, P.N.; Pond, G.R.; Moore, M.J.; Oza, A.; Burkes, R.L.; Siu, L.L.; Feld, R.; Gallinger, S.; Greig, P.; Knox, J.J. Natural History and Chemotherapy Effectiveness for Advanced Adenocarcinoma of the Small Bowel: A Retrospective Review of 113 Cases. Am. J. Clin. Oncol. 2006, 29, 225–231. [Google Scholar] [CrossRef]
  10. Czaykowski, P.; Hui, D. Chemotherapy in Small Bowel Adenocarcinoma: 10-Year Experience of the British Columbia Cancer Agency. Clin. Oncol. 2007, 19, 143–149. [Google Scholar] [CrossRef]
  11. Moon, Y.W.; Rha, S.Y.; Shin, S.J.; Chang, H.; Shim, H.S.; Roh, J.K. Adenocarcinoma of the Small Bowel at a Single Korean Institute: Management and Prognosticators. J. Cancer Res. Clin. Oncol. 2010, 136, 387–394. [Google Scholar] [CrossRef] [PubMed]
  12. Koo, D.H.; Yun, S.-C.; Hong, Y.S.; Ryu, M.-H.; Lee, J.-L.; Chang, H.-M.; Ryoo, B.-Y.; Kang, Y.-K.; Kim, T.W. Systemic Chemotherapy for Treatment of Advanced Small Bowel Adenocarcinoma with Prognostic Factor Analysis: Retrospective Study. BMC Cancer 2011, 11, 205. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  13. Khan, K.; Peckitt, C.; Sclafani, F.; Watkins, D.; Rao, S.; Starling, N.; Jain, V.; Trivedi, S.; Stanway, S.; Cunningham, D.; et al. Prognostic Factors and Treatment Outcomes in Patients with Small Bowel Adenocarcinoma (SBA): The Royal Marsden Hospital (RMH) Experience. BMC Cancer 2015, 15, 15. [Google Scholar] [CrossRef] [Green Version]
  14. Halfdanarson, T.R.; McWilliams, R.R.; Donohue, J.H.; Quevedo, J.F. A Single-Institution Experience with 491 Cases of Small Bowel Adenocarcinoma. Am. J. Surg. 2010, 199, 797–803. [Google Scholar] [CrossRef] [PubMed]
  15. Gibson, M.K.; Holcroft, C.A.; Kvols, L.K.; Haller, D. Phase II Study of 5-Fluorouracil, Doxorubicin, and Mitomycin C for Metastatic Small Bowel Adenocarcinoma. Oncologist 2005, 10, 132–137. [Google Scholar] [CrossRef] [Green Version]
  16. Overman, M.J.; Varadhachary, G.R.; Kopetz, S.; Adinin, R.; Lin, E.; Morris, J.S.; Eng, C.; Abbruzzese, J.L.; Wolff, R.A. Phase II Study of Capecitabine and Oxaliplatin for Advanced Adenocarcinoma of the Small Bowel and Ampulla of Vater. J. Clin. Oncol. 2009, 27, 2598–2603. [Google Scholar] [CrossRef] [Green Version]
  17. Xiang, X.J.; Liu, Y.W.; Zhang, L.; Qiu, F.; Yu, F.; Zhan, Z.Y.; Feng, M.; Yan, J.; Zhao, J.G.; Xiong, J.P. A Phase II Study of Modified FOLFOX as First-Line Chemotherapy in Advanced Small Bowel Adenocarcinoma. Anticancer Drugs 2012, 23, 561–566. [Google Scholar] [CrossRef]
  18. Horimatsu, T.; Nakayama, N.; Moriwaki, T.; Hirashima, Y.; Fujita, M.; Asayama, M.; Moriyama, I.; Nakashima, K.; Baba, E.; Kitamura, H.; et al. A Phase II Study of 5-Fluorouracil/L-Leucovorin/Oxaliplatin (MFOLFOX6) in Japanese Patients with Metastatic or Unresectable Small Bowel Adenocarcinoma. Int. J. Clin. Oncol. 2017, 22, 905–912. [Google Scholar] [CrossRef] [Green Version]
  19. Overman, M.J.; Adam, L.; Raghav, K.; Wang, J.; Kee, B.; Fogelman, D.; Eng, C.; Vilar, E.; Shroff, R.; Dasari, A.; et al. Phase II Study of Nab-Paclitaxel in Refractory Small Bowel Adenocarcinoma and CpG Island Methylator Phenotype (CIMP)-High Colorectal Cancer. Ann. Oncol. 2018, 29, 139–144. [Google Scholar] [CrossRef]
  20. McWilliams, R.R.; Foster, N.R.; Mahoney, M.R.; Smyrk, T.C.; Murray, J.A.; Ames, M.M.; Horvath, L.E.; Schneider, D.J.; Hobday, T.J.; Jatoi, A.; et al. North Central Cancer Treatment Group N0543 (Alliance): A Phase 2 Trial of Pharmacogenetic-Based Dosing of Irinotecan, Oxaliplatin, and Capecitabine as First-Line Therapy for Patients with Advanced Small Bowel Adenocarcinoma. Cancer 2017, 123, 3494–3501. [Google Scholar] [CrossRef]
  21. Crawley, C.; Ross, P.; Norman, A.; Hill, A.; Cunningham, D. The Royal Marsden Experience of a Small Bowel Adenocarcinoma Treated with Protracted Venous Infusion 5-Fluorouracil. Br. J. Cancer 1998, 78, 508–510. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  22. Locher, C.; Malka, D.; Boige, V.; Lebray, P.; Elias, D.; Lasser, P.; Ducreux, M. Combination Chemotherapy in Advanced Small Bowel Adenocarcinoma. Oncology 2005, 69, 290–294. [Google Scholar] [CrossRef]
  23. Overman, M.J.; Kopetz, S.; Wen, S.; Hoff, P.M.; Fogelman, D.; Morris, J.; Abbruzzese, J.L.; Ajani, J.A.; Wolff, R.A. Chemotherapy with 5-Fluorouracil and a Platinum Compound Improves Outcomes in Metastatic Small Bowel Adenocarcinoma. Cancer 2008, 113, 2038–2045. [Google Scholar] [CrossRef]
  24. Zaanan, A.; Costes, L.; Gauthier, M.; Malka, D.; Locher, C.; Mitry, E.; Tougeron, D.; Lecomte, T.; Gornet, J.-M.; Sobhani, I.; et al. Chemotherapy of Advanced Small-Bowel Adenocarcinoma: A Multicenter AGEO Study. Ann. Oncol. 2010, 21, 1786–1793. [Google Scholar] [CrossRef] [PubMed]
  25. Zaanan, A.; Gauthier, M.; Malka, D.; Locher, C.; Gornet, J.-M.; Thirot-Bidault, A.; Tougeron, D.; Taïeb, J.; Bonnetain, F.; Aparicio, T.; et al. Second-Line Chemotherapy with Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI Regimen) in Patients with Advanced Small Bowel Adenocarcinoma after Failure of First-Line Platinum-Based Chemotherapy: A Multicenter AGEO Study. Cancer 2011, 117, 1422–1428. [Google Scholar] [CrossRef] [PubMed]
  26. Tsushima, T.; Taguri, M.; Honma, Y.; Takahashi, H.; Ueda, S.; Nishina, T.; Kawai, H.; Kato, S.; Suenaga, M.; Tamura, F.; et al. Multicenter Retrospective Study of 132 Patients with Unresectable Small Bowel Adenocarcinoma Treated with Chemotherapy. Oncologist 2012, 17, 1163–1170. [Google Scholar] [CrossRef] [Green Version]
  27. Aydin, D.; Sendur, M.A.; Kefeli, U.; Umut Unal, O.; Tastekin, D.; Akyol, M.; Tanrikulu, E.; Ciltas, A.; Bala Ustaalioglu, B.; Sener Dede, D.; et al. Evaluation of Prognostic Factors and Treatment in Advanced Small Bowel Adenocarcinoma: Report of a Multi-Institutional Experience of Anatolian Society of Medical Oncology (ASMO). J. BUON 2016, 21, 1242–1249. [Google Scholar] [PubMed]
  28. Aldrich, J.D.; Raghav, K.P.S.; Varadhachary, G.R.; Wolff, R.A.; Overman, M.J. Retrospective Analysis of Taxane-Based Therapy in Small Bowel Adenocarcinoma. Oncologist 2019, 24, e384–e386. [Google Scholar] [CrossRef] [Green Version]
  29. Overman, M.J.; Pozadzides, J.; Kopetz, S.; Wen, S.; Abbruzzese, J.L.; Wolff, R.A.; Wang, H. Immunophenotype and Molecular Characterisation of Adenocarcinoma of the Small Intestine. Br. J. Cancer 2010, 102, 144–150. [Google Scholar] [CrossRef] [Green Version]
  30. Amano, T.; Iijima, H.; Shinzaki, S.; Tashiro, T.; Iwatani, S.; Tani, M.; Otake, Y.; Yoshihara, T.; Sugimoto, A.; Egawa, S.; et al. Vascular Endothelial Growth Factor-A Is an Immunohistochemical Biomarker for the Efficacy of Bevacizumab-Containing Chemotherapy for Duodenal and Jejunal Adenocarcinoma. BMC Cancer 2021, 21, 978. [Google Scholar] [CrossRef]
  31. Aydin, D.; Sendur, M.A.; Kefeli, U.; Ustaalioglu, B.B.; Aydin, O.; Yildirim, E.; Isik, D.; Ozcelik, M.; Surmeli, H.; Oyman, A.; et al. Evaluation of Bevacizumab in Advanced Small Bowel Adenocarcinoma. Clin. Colorectal Cancer 2017, 16, 78–83. [Google Scholar] [CrossRef] [PubMed]
  32. Takayoshi, K.; Kusaba, H.; Uenomachi, M.; Mitsugi, K.; Makiyama, C.; Makiyama, A.; Uchino, K.; Shirakawa, T.; Shibata, Y.; Shinohara, Y.; et al. Suggestion of Added Value by Bevacizumab to Chemotherapy in Patients with Unresectable or Recurrent Small Bowel Cancer. Cancer Chemother. Pharmacol. 2017, 80, 333–342. [Google Scholar] [CrossRef] [PubMed]
  33. Hirao, M.; Komori, M.; Nishida, T.; Iijima, H.; Yamaguchi, S.; Ishihara, R.; Yasunaga, Y.; Kobayashi, I.; Kishida, O.; Oshita, M.; et al. Clinical Use of Molecular Targeted Agents for Primary Small Bowel Adenocarcinoma: A Multicenter Retrospective Cohort Study by the Osaka Gut Forum. Oncol. Lett. 2017, 14, 1628–1636. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  34. Gulhati, P.; Raghav, K.; Shroff, R.T.; Varadhachary, G.R.; Kopetz, S.; Javle, M.; Qiao, W.; Wang, H.; Morris, J.; Wolff, R.A.; et al. Bevacizumab Combined with Capecitabine and Oxaliplatin in Patients with Advanced Adenocarcinoma of the Small Bowel or Ampulla of Vater: A Single-Center, Open-Label, Phase 2 Study. Cancer 2017, 123, 1011–1017. [Google Scholar] [CrossRef] [Green Version]
  35. Santini, D.; Fratto, M.E.; Spoto, C.; Russo, A.; Galluzzo, S.; Zoccoli, A.; Vincenzi, B.; Tonini, G. Cetuximab in Small Bowel Adenocarcinoma: A New Friend? Br. J. Cancer 2010, 103, 1305, author reply 1306. [Google Scholar] [CrossRef]
  36. Dell’Aquila, E.; Zeppola, T.; Stellato, M.; Pantano, F.; Scartozzi, M.; Madaudo, C.; Pietrantonio, F.; Cremolini, C.; Aprile, G.; Vincenzi, B.; et al. Anti-EGFR Therapy in Metastatic Small Bowel Adenocarcinoma: Myth or Reality? Clin. Med. Insights Oncol. 2020, 14, 1179554920946693. [Google Scholar] [CrossRef]
  37. Serpas, V.; Raghav, K.P.S.; Varadhachary, G.R.; Wolff, R.A.; Overman, M.J. A Retrospective Study of Anti-EGFR Antibody Therapy in Small Bowel Adenocarcinoma. JCO 2018, 36, e16264. [Google Scholar] [CrossRef]
  38. Gulhati, P.; Raghav, K.; Shroff, R.; Varadhachary, G.; Javle, M.; Qiao, W.; Wang, H.; Morris, J.; Wolff, R.; Overman, M.J. Phase II Study of Panitumumab in RAS Wild-Type Metastatic Adenocarcinoma of Small Bowel or Ampulla of Vater. Oncologist 2018, 23, 277-e26. [Google Scholar] [CrossRef] [Green Version]
  39. Akiyama, N.; Karayama, M.; Iwaizumi, M.; Kusama, Y.; Kono, M.; Hozumi, H.; Suzuki, Y.; Furuhashi, K.; Enomoto, N.; Fujisawa, T.; et al. Synchronous Duodenal Cancer and Lung Cancer Harboring an Epidermal Growth Factor Receptor Mutation Treated with Erlotinib and Oral Fluoropyrimidine. Intern. Med. 2017, 56, 2367–2371. [Google Scholar] [CrossRef] [Green Version]
  40. Le, D.T.; Durham, J.N.; Smith, K.N.; Wang, H.; Bartlett, B.R.; Aulakh, L.K.; Lu, S.; Kemberling, H.; Wilt, C.; Luber, B.S.; et al. Mismatch Repair Deficiency Predicts Response of Solid Tumors to PD-1 Blockade. Science 2017, 357, 409–413. [Google Scholar] [CrossRef] [Green Version]
  41. Marabelle, A.; Le, D.T.; Ascierto, P.A.; Di Giacomo, A.M.; De Jesus-Acosta, A.; Delord, J.-P.; Geva, R.; Gottfried, M.; Penel, N.; Hansen, A.R.; et al. Efficacy of Pembrolizumab in Patients With Noncolorectal High Microsatellite Instability/Mismatch Repair-Deficient Cancer: Results From the Phase II KEYNOTE-158 Study. J. Clin. Oncol. 2020, 38, 1–10. [Google Scholar] [CrossRef] [PubMed]
  42. Pedersen, K.S.; Foster, N.R.; Overman, M.J.; Boland, P.M.; Kim, S.S.; Arrambide, K.A.; Jaszewski, B.L.; Bekaii-Saab, T.; Graham, R.P.; Welch, J.; et al. ZEBRA: A Multicenter Phase II Study of Pembrolizumab in Patients with Advanced Small-Bowel Adenocarcinoma. Clin. Cancer Res. 2021, 27, 3641–3648. [Google Scholar] [CrossRef] [PubMed]
  43. Aparicio, T.; Zaanan, A.; Mary, F.; Afchain, P.; Manfredi, S.; Evans, T.R.J. Small Bowel Adenocarcinoma. Gastroenterol. Clin. N. Am. 2016, 45, 447–457. [Google Scholar] [CrossRef] [PubMed]
  44. Schrock, A.B.; Devoe, C.E.; McWilliams, R.; Sun, J.; Aparicio, T.; Stephens, P.J.; Ross, J.S.; Wilson, R.; Miller, V.A.; Ali, S.M.; et al. Genomic Profiling of Small-Bowel Adenocarcinoma. JAMA Oncol. 2017, 3, 1546–1553. [Google Scholar] [CrossRef] [Green Version]
  45. Hamad, A.; Singhi, A.D.; Bahary, N.; McGrath, K.; Amarin, R.; Zeh, H.J.; Zureikat, A.H. Neoadjuvant Treatment With Trastuzumab and FOLFOX Induces a Complete Pathologic Response in a Metastatic ERBB2 (HER2)-Amplified Duodenal Cancer. J. Natl. Compr. Cancer Netw. 2017, 15, 983–988. [Google Scholar] [CrossRef] [Green Version]
  46. Hong, D.S.; DuBois, S.G.; Kummar, S.; Farago, A.F.; Albert, C.M.; Rohrberg, K.S.; van Tilburg, C.M.; Nagasubramanian, R.; Berlin, J.D.; Federman, N.; et al. Larotrectinib in Patients with TRK Fusion-Positive Solid Tumours: A Pooled Analysis of Three Phase 1/2 Clinical Trials. Lancet Oncol. 2020, 21, 531–540. [Google Scholar] [CrossRef]
  47. Benson, A.B.; Venook, A.P.; Al-Hawary, M.M.; Arain, M.A.; Chen, Y.-J.; Ciombor, K.K.; Cohen, S.A.; Cooper, H.S.; Deming, D.A.; Garrido-Laguna, I.; et al. Small Bowel Adenocarcinoma, Version 1.2020, NCCN Clinical Practice Guidelines in Oncology. J. Natl. Compr. Cancer Netw. 2019, 17, 1109–1133. [Google Scholar] [CrossRef]
  48. Le, D.T.; Uram, J.N.; Wang, H.; Bartlett, B.R.; Kemberling, H.; Eyring, A.D.; Skora, A.D.; Luber, B.S.; Azad, N.S.; Laheru, D.; et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N. Engl. J. Med. 2015, 372, 2509–2520. [Google Scholar] [CrossRef] [Green Version]
  49. Reck, M.; Rodríguez-Abreu, D.; Robinson, A.G.; Hui, R.; Csőszi, T.; Fülöp, A.; Gottfried, M.; Peled, N.; Tafreshi, A.; Cuffe, S.; et al. Pembrolizumab versus Chemotherapy for PD-L1-Positive Non-Small-Cell Lung Cancer. N. Engl. J. Med. 2016, 375, 1823–1833. [Google Scholar] [CrossRef] [Green Version]
  50. Cortes, J.; Cescon, D.W.; Rugo, H.S.; Nowecki, Z.; Im, S.-A.; Yusof, M.M.; Gallardo, C.; Lipatov, O.; Barrios, C.H.; Holgado, E.; et al. Pembrolizumab plus Chemotherapy versus Placebo plus Chemotherapy for Previously Untreated Locally Recurrent Inoperable or Metastatic Triple-Negative Breast Cancer (KEYNOTE-355): A Randomised, Placebo-Controlled, Double-Blind, Phase 3 Clinical Trial. Lancet 2020, 396, 1817–1828. [Google Scholar] [CrossRef]
  51. Shitara, K.; Van Cutsem, E.; Bang, Y.-J.; Fuchs, C.; Wyrwicz, L.; Lee, K.-W.; Kudaba, I.; Garrido, M.; Chung, H.C.; Lee, J.; et al. Efficacy and Safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy Alone for Patients With First-Line, Advanced Gastric Cancer: The KEYNOTE-062 Phase 3 Randomized Clinical Trial. JAMA Oncol. 2020, 6, 1571–1580. [Google Scholar] [CrossRef] [PubMed]
  52. Marabelle, A.; Fakih, M.; Lopez, J.; Shah, M.; Shapira-Frommer, R.; Nakagawa, K.; Chung, H.C.; Kindler, H.L.; Lopez-Martin, J.A.; Miller, W.H.; et al. Association of Tumour Mutational Burden with Outcomes in Patients with Advanced Solid Tumours Treated with Pembrolizumab: Prospective Biomarker Analysis of the Multicohort, Open-Label, Phase 2 KEYNOTE-158 Study. Lancet Oncol. 2020, 21, 1353–1365. [Google Scholar] [CrossRef]
  53. Zhou, C.-B.; Zhou, Y.-L.; Fang, J.-Y. Gut Microbiota in Cancer Immune Response and Immunotherapy. Trends Cancer 2021, 7, 647–660. [Google Scholar] [CrossRef] [PubMed]
  54. Chen, X.; Kang, R.; Kroemer, G.; Tang, D. Broadening Horizons: The Role of Ferroptosis in Cancer. Nat. Rev. Clin. Oncol. 2021, 18, 280–296. [Google Scholar] [CrossRef]
  55. Rompteaux, P.; Gagnière, J.; Gornet, J.-M.; Coriat, R.; Baumgaertner, I.; Lecomte, T.; Afchain, P.; Zaanan, A.; Pocard, M.; Bachet, J.-B.; et al. Resection of Small Bowel Adenocarcinoma Metastases: Results of the ARCAD-NADEGE Cohort Study. Eur. J. Surg. Oncol. 2019, 45, 331–335. [Google Scholar] [CrossRef]
  56. de Bree, E.; Rovers, K.P.; Stamatiou, D.; Souglakos, J.; Michelakis, D.; de Hingh, I.H. The Evolving Management of Small Bowel Adenocarcinoma. Acta Oncol. 2018, 57, 712–722. [Google Scholar] [CrossRef] [Green Version]
  57. Marchettini, P.; Sugarbaker, P.H. Mucinous Adenocarcinoma of the Small Bowel with Peritoneal Seeding. Eur. J. Surg. Oncol. 2002, 28, 19–23. [Google Scholar] [CrossRef]
  58. Jacks, S.P.; Hundley, J.C.; Shen, P.; Russell, G.B.; Levine, E.A. Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma. J. Surg. Oncol. 2005, 91, 112–117, discussion 118–119. [Google Scholar] [CrossRef]
  59. Chua, T.C.; Koh, J.-L.; Yan, T.D.; Liauw, W.; Morris, D.L. Cytoreductive Surgery and Perioperative Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma. J. Surg. Oncol. 2009, 100, 139–143. [Google Scholar] [CrossRef]
  60. Elias, D.; Glehen, O.; Pocard, M.; Quenet, F.; Goéré, D.; Arvieux, C.; Rat, P.; Gilly, F.; Association Française de Chirurgie. A Comparative Study of Complete Cytoreductive Surgery Plus Intraperitoneal Chemotherapy to Treat Peritoneal Dissemination From Colon, Rectum, Small Bowel, and Nonpseudomyxoma Appendix. Ann. Surg. 2010, 251, 896–901. [Google Scholar] [CrossRef]
  61. van Oudheusden, T.R.; Lemmens, V.E.; Braam, H.J.; van Ramshorst, B.; Meijerink, J.; te Velde, E.A.; Mehta, A.M.; Verwaal, V.J.; de Hingh, I.H. Peritoneal Metastases from Small Bowel Cancer: Results of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in The Netherlands. Surgery 2015, 157, 1023–1027. [Google Scholar] [CrossRef]
  62. Liu, Y.; Yonemura, Y.; Levine, E.A.; Glehen, O.; Goere, D.; Elias, D.; Morris, D.L.; Sugarbaker, P.H.; Tuech, J.J.; Cashin, P.; et al. Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Metastases From a Small Bowel Adenocarcinoma: Multi-Institutional Experience. Ann. Surg. Oncol. 2018, 25, 1184–1192. [Google Scholar] [CrossRef] [Green Version]
  63. Liu, Y.; Ishibashi, H.; Takeshita, K.; Mizumoto, A.; Hirano, M.; Sako, S.; Takegawa, S.; Takao, N.; Ichinose, M.; Yonemura, Y. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Dissemination from Small Bowel Malignancy: Results from a Single Specialized Center. Ann. Surg. Oncol. 2016, 23, 1625–1631. [Google Scholar] [CrossRef] [PubMed]
  64. Sun, Y.; Shen, P.; Stewart, J.H.; Russell, G.B.; Levine, E.A. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Carcinomatosis from Small Bowel Adenocarcinoma. Am. Surg. 2013, 79, 644–648. [Google Scholar] [CrossRef] [PubMed]
  65. Rovers, K.P.; de Bree, E.; Yonemura, Y.; de Hingh, I.H. Treatment of Peritoneal Metastases from Small Bowel Adenocarcinoma. Int. J. Hyperth. 2017, 33, 571–578. [Google Scholar] [CrossRef] [PubMed] [Green Version]
Table
Table 1. Retrospective and prospective studies comparing chemotherapy versus best supportive care in advanced small bowel adenocarcinoma.
Table 1. Retrospective and prospective studies comparing chemotherapy versus best supportive care in advanced small bowel adenocarcinoma.
ReferencesType of StudyNumber of Patients Type of CTNumber of Patients (%)Patients Treated with CT (Months)OS in Patients
without CT
(Months)		p-Value
TotalReceiving CTNot Receiving CTORRDCROS (Months)
Dabaja, Cancer, 2004 [6]Retrospective753441NA---1220.02
Fishman, Am J Oncol, 2006 [9]Retrospective10544 61Various regimens-29.5%50%19130.035 (in multivariate analysis)
Moon, J Cancer Res Clin Oncol, 2010 [11] Retrospective873453All-27.6%-93.50.01
5-FU4 (11.8%)
5-FU–cisplatin11 (32.4%)
5-FU-based adriamycin 14 (41.2%)
Gemcitabine2 (5.8%)
Other regimens3 (8.8%)
Czaykowski, Clin Oncol, 2007 [10]Retrospective37 16215-FU based 5%-15.67.7NA
Koo, BMC Cancer, 2011 [12]Retrospective914051All-11.1%37.0%11.84.1<0.01
5-FU10 (24.0%)
5-FU–cisplatin25 (62.5%)
FOLFIRI3 (7.5%)
5-FU–adriamycin–mitomycin2 (5.0%)
Khan, BMC Cancer, 2015 [13]Retrospective594659Various regimens-50%-60.9%
(1-year OS)		27.1%
(1-year OS)		0.04
Halfdanarson, Am J Surg, 2010 [14]Retrospective165NANANA---15.55.3<0.01
Aparicio, Int J Cancer, 2020 [4]Prospective124 *8615All---14.62.20.0001
5-FU6 (7.0%)-----
FOLFOX/CAPOX60 (69.8%)-----
FOFLIRI 16 (18.6%)-----
Other regimens4 (4.6%)-----
Abbreviations: DCR: disease control rate; CT: chemotherapy; NA: not available; ORR: objective response rate; OS: overall survival * 23 patients with NA data.
Table
Table 2. Evaluation of different chemotherapy regimens in advanced small bowel adenocarcinoma.
Table 2. Evaluation of different chemotherapy regimens in advanced small bowel adenocarcinoma.
ReferencesType of StudyNumber of Patients Line of TreatmentType of CT (Number of Patients) ORRDisease Control RateMedian PFS (Months)Median OS (Months)
Crawley, Br J Cancer, 1998 [21]Retrospective
Single Center		81All (n = 8)-75%7.813
ECF (n = 5) -80%--
5-FU (n = 2)-50%--
5-FU–mitomycin (n = 1)-100% --
Locher, Oncology, 2005 [22]Retrospective
Single Center 		201
2		All (n = 20)21%79%8 14
5-FU–cisplatin (n = 15)20% ---
5-FU–carboplatin (n = 2)0%---
FOLFOX (n = 3)33%---
All (n = 13)----
FOLFIRI (n = 8)-50%5 -
5-FU–cisplatin (n = 1)0%0%--
5-FU (n = 4)0%0%--
Overman, Cancer, 2008 [23]Retrospective
Single Center 		801All (n = 80)71%-4.613.0
5-FU–cisplatin (n = 29) 41%-8.714.8
5-FU alone/non 5-FU-based (n = 51)30%-3.912.0
Zaanan, Ann Oncol, 2010 [24]Retrospective
Multicentric		931 All (n = 93)26%74%6.615.1
5-FU (n = 10)0%50%7.713.5
FOLFOX (n = 48)34%79%6.917.8
FOLFIRI (n = 19) 34%73%6.010.6
5-FU-cisplatin (n = 16) 31%69%4.8 9.3
Zaanan, Cancer, 2011 [25]Retrospective
Multicentric		282FOLFIRI (n = 28)20%52%3.2 10.5
Tsushima, Oncologist, 2012 [26]Retrospective
Multicentric		1321All (n = 132)----
5-FU (n = 60)20%-5.413.9
5-FU–cisplatin (n = 17)38%-3.812.6
FOLFOX (n = 22)42%-8.222.2
FOLFIRI (n = 11)25%-5.69.4
Other regimens (n = 22)21%-3.48.1
Aydin, J BUON, 2016 [27]Retrospective
Multicentric		561All (n = 56)--713
FOLFOX (n = 18)35%-715
5-FU–cisplatin (n = 17)56%-811
FOLFIRI (n = 18)55%-816
Gemcitabine (n = 10)20%-511
Aldrich, Oncologist, 2019 [28]Retrospective
Single Center		201 or 2All: Taxane-based (n = 20)65%-3.810.7
Combination (n = 17) ----
Monotherapy (n = 3)----
Gibson, Oncologist, 2005 [15]Phase II
Multicentric 		3915-FU–mitomycin–doxorubicin18.4% 31%58
Overman, J Clin Oncol, 2009 [16]Phase II
Single Center 		301CAPOX50%87%11.320.4
Xiang, Anticancer Drugs, 2012 [17]Phase II
Multicentric		331FOLFOX48.5%-7.815.2
Horimatsu, Int J Clin Oncol, 2017 [18]Phase II
Multicentric		241FOLFOX45%80%5.417.3
Mc Williams, Cancers, 2017 [20]Phase II
Single Center		321CAPIRINOX37.5%-8.913.4
Overman, Ann Oncol, 2018 [19]Phase II
Single Center 		10>1Nab-paclitaxel20%50%3.210.9
Abbreviations: ORR: objective response rate; OS: overall response; PFS: progression-free survival; CT, chemotherapy.
Table
Table 3. Main studies evaluating targeted therapies or immune checkpoint inhibitors in advanced small bowel adenocarcinoma.
Table 3. Main studies evaluating targeted therapies or immune checkpoint inhibitors in advanced small bowel adenocarcinoma.
ReferencesType of Study Number of PatientsInvestigated Therapies Main Results
Aydin, Clin Colorectal Cancer 2017 [31]Retrospective
Multicenter		28Bevacizumab + CT (n = 12)
CT alone (n = 16)		ORR: 43.7% in the CT group vs. 58.3% in the bevacizumab + CT group (NS)
mPFS: 7.7 months in the CT group vs. 9.6 months in the bevacizumab + CT group (NS)
mOS: 14.8 months in the CT group vs. 18.5 months in the bevacizumab + CT group (NS)
Takayoshi, Cancer Chemother Pharmacol 2017 [32]Retrospective
Single Center		33Bevacizumab + CT (n = 9)
CT + other targeted therapy or CT alone (n = 24)		ORR: 33%.3 in the bevacizumab + CT group
DCR: 55.5% in the bevacizumab + CT group
mOS: 11.4 months among the 24 patients who did not receive bevacizumab in any of the treatment lines versus 21.9 months in the bevacizumab + CT group (p = 0.179).
Hirao, Oncol Lett, 2017 [33]Retrospective
Single Center		17Bevacizumab + CT (n = 7)
Cetuximab + CT (n = 1)
CT alone (n = 9)		Among the 17 patients who received oxaliplatin-based CT in first-line, a PS of 0 (p = 0.0255) and treatment with bevacizumab (p = 0.0121) were significant positive prognostic factors.
Gulhati, Cancer, 2017 [34]Phase II
Single Center		30Bevacizumab + CT (CAPOX)ORR: 48.3% (1 complete response, 13 partial responses)
6 months PFS: 68%–mPFS: 8.7 months–mOS: 12.9 months
NCT04205968Phase II -Ramucirumab + CT (paclitaxel) versus CT (FOLFIRI)Ongoing
Santini, Br J Cancer 2010 [35]Retrospective
Single Center		4Cetuximab + CT (irinotecan)ORR: 75%–DCR: 100%
All 3 responders were KRAS wild-type
Dell’Aquila, Clin Med Insights Oncol, 2020 [36]Retrospective
Multicenter		13Cetuximab + CT ORR: 44% (CR in 15% of patients, PR in 39% of patients)
DCR: 67%
Serpas, J Clin Oncol, 2018 [37]Retrospective
Single Center		25Cetuximab ± CT (n = 19)
Panitumumab ± CT (n = 6)		mPFS: 3.3 months–mOS: 13 months
ORR: 12%–DCR 36%.
All 3 responders were treated in combination with irinotecan and did not previously progress on irinotecan
Patients treated by anti-EGFR in monotherapy (n = 7):
mPFS: 2.2 months
ORR: 0% and best response: SD (n = 1)
Gulhati, Oncologist, 2018 [38]Phase II9Panitumumab monotherapyORR: 0%–DCR: 22% (n = 2)
mPFS: 2.4 months–mOS: 5.7 months
No patients had extended RAS mutations (exons 2/3/4), 2 had a BRAF G469A mutation, and 1 had a PIK3CA H1074R mutation.
Akiyama, Intern Med, 2017 [39]Case report1Erlotinib + S-1Concomitant response of lung and duodenal cancer to the combination of erlotinib and S-1
Marabelle, J Clin Oncol, 2020 [40]Phase II19 SBA among 233 patientsPembrolizumab monotherapyORR: 34.3%
mPFS: 4.1 months–mOS: 23.5 months
Pedersen, Clin Cancer Res, 2021 [41]Phase II40Pembrolizumab monotherapy PR: 8% (n = 3)–Unachieved predefined success criteria of ORR 30%.
mPFS: 2.9 months–mOS: 7.1 months
50% of patients with MSI-H tumors achieved PR and remained alive without progression
1 confirmed PR (3%) was seen in patients with low MSS/MSI tumors and correlated with high tumor mutation burden.
Cardin, J Clin Oncol, 2O2O [42]Phase II-Avelumab 29% RR and 71% DCR
NCT02834013Phase II-Ipilimumab + nivolumab versus nivolumab Ongoing (dedicated to rare tumors, including SBA)
NCT03108131Phase II-Cobimetinib + atezolizumab Ongoing (dedicated to rare tumors, including SBA)
Abbreviations: CT: chemotherapy; DCR: disease control rate; MSI-H: Microsatellite instability high; NS: non-significant; ORR: objective response rate; mOS: median overall survival; mPFS: median progression-free survival; CR: complete response; PR: Partial response; SD: stable disease.
Table
Table 4. Main observational studies evaluating intraperitoneal chemotherapy and cytoreductive surgery.
Table 4. Main observational studies evaluating intraperitoneal chemotherapy and cytoreductive surgery.
ReferencesType of StudyNumber of PatientsMedian OS (Months) from CRS + HIPECMedian OS (Months) from DiagnosisGrade III–IV ToxicitiesTreatment-Related Death
Marchettini, Eur J Surg Oncol, 2002 [57]Retrospective
Single Center		616--0%
Jacks, J Surg Oncol, 2005 [58]Retrospective
Single Center		630.154--
Chua, J Surg Oncol, 2009 [59]Retrospective
Single Center		725-29%0%
Elias, Ann Surg, 2010 [60]Retrospective
Multicenter		3147-35%2.9%
Sun, Am Surg, 2013 [64]Prospective
Single Center		17183712%0%
van Oudheusden, Surgery, 2015 [61]Retrospective
Multicenter		1631-25%NA
Liu, Ann Surg Oncol, 2016 [63]Retrospective
Single Center		31365125.8%0%
Liu, Ann Surg, 2018 [62]Retrospective
Multicenter		15232-19.1%2%
Abbreviations: OS: overall survival; CRS: cytoreductive surgery; HIPEC: hyperthermic intraperitoneal chemotherapy.
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Moati, E.; Overman, M.J.; Zaanan, A. Therapeutic Strategies for Patients with Advanced Small Bowel Adenocarcinoma: Current Knowledge and Perspectives. Cancers 2022, 14, 1137. https://doi.org/10.3390/cancers14051137

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Moati E, Overman MJ, Zaanan A. Therapeutic Strategies for Patients with Advanced Small Bowel Adenocarcinoma: Current Knowledge and Perspectives. Cancers. 2022; 14(5):1137. https://doi.org/10.3390/cancers14051137

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Moati, Emilie, Michael J. Overman, and Aziz Zaanan. 2022. "Therapeutic Strategies for Patients with Advanced Small Bowel Adenocarcinoma: Current Knowledge and Perspectives" Cancers 14, no. 5: 1137. https://doi.org/10.3390/cancers14051137

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Moati, E., Overman, M. J., & Zaanan, A. (2022). Therapeutic Strategies for Patients with Advanced Small Bowel Adenocarcinoma: Current Knowledge and Perspectives. Cancers, 14(5), 1137. https://doi.org/10.3390/cancers14051137

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