Next Article in Journal
Urinary, Gastrointestinal, and Sexual Dysfunctions after Chemotherapy, Radiotherapy, Radical Surgery or Multimodal Treatment in Women with Locally Advanced Cervical Cancer: A Multicenter Retrospective Study
Previous Article in Journal
Strategy for Pediatric Patients with Relapsed or Refractory Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma: A Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Cancers
Volume 15
Issue 24
10.3390/cancers15245732
Review Report
cancers-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
Article
Peer-Review Record

Telomere Maintenance Mechanisms in a Cohort of High-Risk Neuroblastoma Tumors and Its Relation to Genomic Variants in the TERT and ATRX Genes

Cancers 2023, 15(24), 5732; https://doi.org/10.3390/cancers15245732
by Anna Djos 1, Ketan Thombare 1, Roshan Vaid 1, Jennie Gaarder 1,2, Ganesh Umapathy 1, Susanne E. Reinsbach 3, Kleopatra Georgantzi 4, Jakob Stenman 4, Helena Carén 5, Torben Ek 6, Tanmoy Mondal 1,7, Per Kogner 4, Tommy Martinsson 1 and Susanne Fransson 1,2,*
Reviewer 1:
Maximilian Scheer
Reviewer 2: Anonymous
Reviewer 3: Anonymous
Cancers 2023, 15(24), 5732; https://doi.org/10.3390/cancers15245732
Submission received: 9 November 2023 / Revised: 29 November 2023 / Accepted: 1 December 2023 / Published: 7 December 2023
(This article belongs to the Section Pediatric Oncology)

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

In their work, the authors discuss the connection between microdeletion and known mutations, such as TERT, in neuroblastomas. Overall, the manuscript is very well written, clearly structured and easy to understand. The results provide valuable information for future studies.

I have only minor comments:

The reader may be somewhat confused about the exact size of the study cohort:

- Page 3, line 111: tumour sampes n=232

 Table 1, Study cohort - but study cohort only includes column 1? It is not   entirely clear here whether columns 2 and 3 belong to the study cohort  (subgroup) or are a comparison group

 Page 7, section 3.3 - 22 patients with ATRX (Table 1, however, 21?)

 Please check the numbers in the text. An overview of the breakdown of the  cohort and the groups with ARTX and TERT mutation may help with understanding

 

- Page 2, line 55: dot after "pairs." please remove

- Page 4, line 164 - 200 ul - please correct unit

Author Response

Please see the attachment.

Reviewer 2 Report

Comments and Suggestions for Authors

This is a very nice evaluation of the role of telomere maintenance mechanisms in high risk neuroblastoma among a Swedish patient cohort. The data presented is similar to other data evaluating TMMs. 

How is the presented data unique? There is a sentence at the end of the paper suggesting that therapies that target the difference subgroups need to be determined. This is a start to addressing how this work can be used. 

To make this paper more meaningful, there needs to be focus on how the findings add to the current understanding of TMMs and how this can be used to optimize therapeutic strategies.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 3 Report

Comments and Suggestions for Authors

Seems no need for section 2.7 Kaplan-Meyer analyses of overall survval   -   none are presented in Results

Comments on the Quality of English Language

satisfactory quality, only a few minor edits can be considered

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Back to TopTop