Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review
Abstract
:1. Introduction
2. Materials and Methods
2.1. Search Strategy
2.2. Research Questions
2.3. Primary Study Selection
2.4. Supplementary Material
3. Results and Discussion
3.1. Overview of the Articles
3.2. Research Questions (RQ)
3.2.1. RQ1. At What Stage of Development Is the Chitosan/Insulin Delivery System?
3.2.2. RQ2. What Are the Release Systems Developed?
Nanoparticles
Gel (Hydrogel and Microgel)
Microparticles (Microspheres and Beads)
Films
3.2.3. RQ3. What Are the Main Alternative Ways of Administration Suggested?
3.2.4. RQ4. What Is the Total Amount of Insulin Loaded and the Encapsulation Efficiency of the Release System?
3.2.5. RQ5. For How Long Did the System Release the Insulin?
4. Risk of Biases
4.1. Primary Study Identification
4.2. Quality of Studies and Data Extraction Consistency
4.3. Data Synthesis and Results Reporting
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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RQ | Description | Motivation |
---|---|---|
RQ1 | At what phase is the development of the chitosan/insulin delivery system? | This question provides a starting point to investigate the temporal progress of the development of chitosan/insulin release systems. |
RQ2 | What are the release systems developed? | The aim was to classify and identify the models developed from 1998 to 2018. |
RQ3 | What are the main alternative ways of administration suggested? | This question aims to identify the alternative administration forms proposed. |
RQ4 | What is the total amount of insulin loaded and the encapsulation efficiency of the release system? | This question intends to investigate the efficiency of the methods used to prepare the delivery system. |
RQ5 | For how long did the system release insulin? | The answer to this question allows knowledge of how long the systems can control glucose levels. |
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Barbosa, F.C.; Silva, M.C.d.; Silva, H.N.d.; Albuquerque, D.; Gomes, A.A.R.; Silva, S.M.d.L.; Fook, M.V.L. Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review. Polymers 2020, 12, 2499. https://doi.org/10.3390/polym12112499
Barbosa FC, Silva MCd, Silva HNd, Albuquerque D, Gomes AAR, Silva SMdL, Fook MVL. Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review. Polymers. 2020; 12(11):2499. https://doi.org/10.3390/polym12112499
Chicago/Turabian StyleBarbosa, Francivandi Coelho, Milena Costa da Silva, Henrique Nunes da Silva, Danyllo Albuquerque, Allyson Antônio Ribeiro Gomes, Suédina Maria de Lima Silva, and Marcus Vinícius Lia Fook. 2020. "Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review" Polymers 12, no. 11: 2499. https://doi.org/10.3390/polym12112499
APA StyleBarbosa, F. C., Silva, M. C. d., Silva, H. N. d., Albuquerque, D., Gomes, A. A. R., Silva, S. M. d. L., & Fook, M. V. L. (2020). Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review. Polymers, 12(11), 2499. https://doi.org/10.3390/polym12112499