Immunotherapy in Nonendemic Nasopharyngeal Carcinoma: Real-World Data from Two Nonendemic Regions
, Anastasios Pantazopoulos 1, Aris Spathis 2, Ioannis Kotsantis 1, Anastasios Kyriazoglou 1, George Kavourakis 1, Roubini Zakopoulou 1, Ioannis Chatzidakis 1, Maria Anastasiou 1, Maria Prevezanou 1, Carlo Resteghini 3, Lisa Licitra 3,4, Cristiana Bergamini 3, Elena Colombo 3, Francesca Caspani 3, Nerina Denaro 5, Stefania Vecchio 6, Pierluigi Bonomo 7, Maria Cossu Rocca 8, Federica Bertolini 9, Daris Ferrari 10, add
Show full author list
Round 1
Reviewer 1 Report
The article provides a very interesting compilation of results from clinical trials on R/M NPC ICI treated patients from non-Asian countries (Greece and mostly Italy). This rare small size meta-analysis is of importance for the scientific and medical community in this field and needs to be supported and encouraged to pave the way for other studies of this kind.
Minor point:
Figures need to be in higher resolution for publication
Table 3 present an extra parenthesis in the title of the first column.
Scientific suggestion/Question :
Is their of possibility to get EBV status of the tumour in term of tissue expression of LMP1 or small non-coding RNA of EBV (EBER or BART) ? A correlation with ICI response rate was sometimes observed and could be of interest in this analysis.
Author Response
We thank the reviewer for his/her comments.
1. Figures are prepared according to the journal's recommendations (resolution of 300 dpi).
2. We added an extra parenthesis in table 3.
3. We plan to test this in the future.
Reviewer 2 Report
The manuscript by Economopoulou et al provides interesting insight. However, they need to revise the manuscript to improve the clarity.
Author Response
We thank the reviewer for his/her comments.
We believe that results are very clearly presented. We corrected some typos throughout the manuscript.
