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Volume 14
Issue 12
10.3390/life14121535
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This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

The Intensity of BCL2A1 Expression Increases According to the Stage Progression of Acute Histologic Chorioamnionitis in the Extra-Placental Membranes of Spontaneous Preterm Birth

by
Chan-Wook Park
1,*,†,
Eun-Mi Lee
1,†,
Seung-Han Shin
2,
Chul Lee
3 and
Jae-Kyung Won
3,*
1
The Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
2
The Department of Pediatrics, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
3
The Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Life 2024, 14(12), 1535; https://doi.org/10.3390/life14121535
Submission received: 5 October 2024 / Revised: 14 November 2024 / Accepted: 19 November 2024 / Published: 22 November 2024
(This article belongs to the Special Issue Clinical Management and Prevention of Adverse Pregnancy Outcomes)
Versions Notes

Abstract

Our prior findings showed that BCL2A1 in neutrophils is highly expressed in the extra-placental membranes (EPMs) of both the human spontaneous preterm-birth (PTB) (i.e., PTL or preterm PROM) and nonhuman-primate PTB model. However, no data exist on whether the intensity of BCL2A1 expression quantitatively increases according to the stage progression of acute histologic chorioamnionitis (acute HCA) in EPM. The objective is to investigate whether the intensity of BCL2A1 expression quantitatively increases according to the stage progression of acute HCA in EPM among spontaneous PTB cases, as measured using QuPath. The study population included 121 singleton PTBs (gestational age [GA] at delivery < 34 weeks) due to either preterm labor or preterm PROM. With digital image analysis, we calculated the percentage of BCL2A1-positive cells in immunohistochemistry according to the stage progression of acute HCA in EPMs as the primary outcome and examined the relationship between the percentage of BCL2A1-positive cells and either the GA at delivery or the amniotic-fluid (AF) WBC count as the secondary outcome. The median percentage of BCL2A1-positive cells progressively increases with the stage progression of acute HCA in EPM (group-1 vs. group-2 vs. group-3 vs. group-4 vs. group-5; 7.62 vs. 5.15 vs. 43.57 vs. 71.07; γ = 0.552, p < 0.000001). The percentage of BCL2A1-positive cells in EPMs and the AFWBC count shows a positive correlation (γ = 0.492, p = 0.000385). Moreover, the percentage of BCL2A1-positive cells in EPMs continuously decreased with increasing GA at delivery (γ = −0.253, p = 0.005148). In conclusion, the intensity of BCL2A1 expression increases according to the stage progression of acute HCA in EPMs and the elevation of AFWBC among spontaneous PTB cases. This finding suggests BCL2A1 in EPMs may be a promising marker and target for acute HCA.
Keywords: BCL2A1; stage progression; extra-placental membranes; acute histologic chorioamnionitis; WBC; amniotic fluid; spontaneous preterm birth BCL2A1; stage progression; extra-placental membranes; acute histologic chorioamnionitis; WBC; amniotic fluid; spontaneous preterm birth

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MDPI and ACS Style

Park, C.-W.; Lee, E.-M.; Shin, S.-H.; Lee, C.; Won, J.-K. The Intensity of BCL2A1 Expression Increases According to the Stage Progression of Acute Histologic Chorioamnionitis in the Extra-Placental Membranes of Spontaneous Preterm Birth. Life 2024, 14, 1535. https://doi.org/10.3390/life14121535

AMA Style

Park C-W, Lee E-M, Shin S-H, Lee C, Won J-K. The Intensity of BCL2A1 Expression Increases According to the Stage Progression of Acute Histologic Chorioamnionitis in the Extra-Placental Membranes of Spontaneous Preterm Birth. Life. 2024; 14(12):1535. https://doi.org/10.3390/life14121535

Chicago/Turabian Style

Park, Chan-Wook, Eun-Mi Lee, Seung-Han Shin, Chul Lee, and Jae-Kyung Won. 2024. "The Intensity of BCL2A1 Expression Increases According to the Stage Progression of Acute Histologic Chorioamnionitis in the Extra-Placental Membranes of Spontaneous Preterm Birth" Life 14, no. 12: 1535. https://doi.org/10.3390/life14121535

APA Style

Park, C. -W., Lee, E. -M., Shin, S. -H., Lee, C., & Won, J. -K. (2024). The Intensity of BCL2A1 Expression Increases According to the Stage Progression of Acute Histologic Chorioamnionitis in the Extra-Placental Membranes of Spontaneous Preterm Birth. Life, 14(12), 1535. https://doi.org/10.3390/life14121535

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