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Brain Sciences
Volume 15
Issue 2
10.3390/brainsci15020132
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Review

Natural Source of Drugs Targeting Central Nervous System Tumors—Focus on NAD(P)H Oxidoreductase 1 (NQO1) Activity

by
Nikola M. Stojanovic
1,*,
Milica Mitić
2,3,
Jovan Ilić
3,4,
Milica Radić
3,5,
Miša Radisavljević
3,4,
Marko Baralić
6,7 and
Miljan Krstić
2,8
1
Department of Physiology, Faculty of Medicine, University of Niš, 18000 Niš, Serbia
2
Center for Pathology, University Clinical Centre Niš, 18000 Niš, Serbia
3
Faculty of Medicine, University of Niš, 18000 Niš, Serbia
4
Department for Neurosurgery, University Clinical Centre Niš, 18000 Niš, Serbia
5
Department for radiation oncology, University Clinical Centre Niš, 18000 Niš, Serbia
6
Faculty of Medicine, University of Belgrade, 11080 Belgrade, Serbia
7
Department of Nephrology, University Clinical Centre of Serbia, 11000 Belgrade, Serbia
8
Department of Pathology, Faculty of Medicine, University of Niš, 18000 Niš, Serbia
*
Author to whom correspondence should be addressed.
Brain Sci. 2025, 15(2), 132; https://doi.org/10.3390/brainsci15020132
Submission received: 20 December 2024 / Revised: 27 January 2025 / Accepted: 28 January 2025 / Published: 29 January 2025
(This article belongs to the Special Issue Brain Tumors: From Molecular Basis to Therapy)
Versions Notes

Abstract

Central nervous system (CNS) tumors involve a large and diverse group of malignancies that arise from various cell types within the brain tissue. Although there are advances in treatments, CNS tumors still remain challenging, due to their complex biology and the delicate nature of the surrounding tissue. NAD(P)H O=oxidoreductase 1 (NQO1) is an enzyme that plays a critical role in the detoxification of quinones, protecting cells from oxidative stress. In CNS tumors this enzyme is often overexpressed, which contributes to the resistance of tumor cells to chemotherapy by enhancing their antioxidant defenses. NQO1 influences the progression of CNS tumors by affecting downstream signaling pathways, such as those involving the transcription factor SNAIL, as well as others that are associated with tumor behavior. Plants represent a valuable source of numerous constituents with different chemical structures known to affect different molecular signaling pathways associated with different pathologies.
Keywords: brain tumors; NAD(P)H oxidoreductase; NQO1 protein; glioma; glioblastoma brain tumors; NAD(P)H oxidoreductase; NQO1 protein; glioma; glioblastoma

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MDPI and ACS Style

Stojanovic, N.M.; Mitić, M.; Ilić, J.; Radić, M.; Radisavljević, M.; Baralić, M.; Krstić, M. Natural Source of Drugs Targeting Central Nervous System Tumors—Focus on NAD(P)H Oxidoreductase 1 (NQO1) Activity. Brain Sci. 2025, 15, 132. https://doi.org/10.3390/brainsci15020132

AMA Style

Stojanovic NM, Mitić M, Ilić J, Radić M, Radisavljević M, Baralić M, Krstić M. Natural Source of Drugs Targeting Central Nervous System Tumors—Focus on NAD(P)H Oxidoreductase 1 (NQO1) Activity. Brain Sciences. 2025; 15(2):132. https://doi.org/10.3390/brainsci15020132

Chicago/Turabian Style

Stojanovic, Nikola M., Milica Mitić, Jovan Ilić, Milica Radić, Miša Radisavljević, Marko Baralić, and Miljan Krstić. 2025. "Natural Source of Drugs Targeting Central Nervous System Tumors—Focus on NAD(P)H Oxidoreductase 1 (NQO1) Activity" Brain Sciences 15, no. 2: 132. https://doi.org/10.3390/brainsci15020132

APA Style

Stojanovic, N. M., Mitić, M., Ilić, J., Radić, M., Radisavljević, M., Baralić, M., & Krstić, M. (2025). Natural Source of Drugs Targeting Central Nervous System Tumors—Focus on NAD(P)H Oxidoreductase 1 (NQO1) Activity. Brain Sciences, 15(2), 132. https://doi.org/10.3390/brainsci15020132

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