New Onset of Giant Cell Arteritis following ChAdOx1-S (Vaxevria®) Vaccine Administration
, Rosanna De Giovanni 1, Francesca Maletta 3, Serena Grimaldi 4, Luisa Brussino 2 and Enrico Fusaro 1
Round 1
Reviewer 1 Report
The case report seems a really interesting report, though it needs further improvements in order to provide clearance to the reader. More details you will find in the attached document, where I have included my comments.
Comments for author File: 
Comments.pdf
Author Response
We are extremely grateful for the suggestions the reviewer provided. we proceeded to implement the introduction, adding the related bibliography. Moreover, we split the image of Figure 3 as suggested.
Reviewer 2 Report
This is an interesting case report describing the development of giant cell arteritis following the administration of a second dose of SARS-CoV-2 vaccine (ChAdOx1-S).
Comments: Please address the following points:
1) Line 35 - HBV - please specify the abbreviation in full, i.e. Hepatitis B infection
2) Line 40- 'requested' rather than 'prescribed' would be better here.
3) Line 42 - Please provide the haemoglobin value.
4) Line 52 - Please provide a more detailed time line. How many days post vaccination was it before symptoms developed and referral to the emergency department occurred?
5) Lines 100-101 - 'The association of vasculitis with the administration of vaccines against influenza 100 and pertussis has yet been described in the past (5).' it is not clear what this means, please clarify.
6) Please provide details of the patient's first vaccination. Was there any reaction to this? What was the time interval to the second dose?
Author Response
1) Line 35 - HBV - please specify the abbreviation in full, i.e. Hepatitis B infection. Thanks for this suggestion. We corrected it.
2) Line 40- 'requested' rather than 'prescribed' would be better here. Thanks for your remarks; we proceeded correct it.
3) Line 42 - Please provide the haemoglobin value. Thanks for your remarks; we added the heamoglobin value.
4) Line 52 - Please provide a more detailed time line. How many days post vaccination was it before symptoms developed and referral to the emergency department occurred? Thanks for your remarks, we have implemented the document with the requested informations.
5) Lines 100-101 - 'The association of vasculitis with the administration of vaccines against influenza 100 and pertussis has yet been described in the past (5).' it is not clear what this means, please clarify. We are extremely grateful for the suggestions the reviewer provided. A pathophysiological role of infectious agents in GCA has been hypothesized in the past and a relationship with the influenza vaccine has been described in other case reports. We have implemented the bibliography.
6) Please provide details of the patient's first vaccination. Was there any reaction to this? What was the time interval to the second dose? Thanks for your remarks, we have implemented the document with the requested informations.
